Published in Behav Pharmacol on September 01, 2010
Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. Front Neurosci (2011) 1.04
Toward a neurology of loneliness. Psychol Bull (2014) 0.99
Loneliness: clinical import and interventions. Perspect Psychol Sci (2015) 0.97
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. J Neuroendocrinol (2012) 0.92
Is progesterone a worthy candidate as a novel therapy for traumatic brain injury? Dialogues Clin Neurosci (2011) 0.91
Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder. Front Cell Neurosci (2014) 0.87
S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology (2010) 0.85
Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study. Front Neural Circuits (2012) 0.84
Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression. Front Endocrinol (Lausanne) (2011) 0.83
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response. Front Neuroendocrinol (2014) 0.82
Targeting neurosteroidogenesis as therapy for PTSD. Front Pharmacol (2014) 0.81
Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms. Am J Med Genet B Neuropsychiatr Genet (2013) 0.81
Neurosteroid biosynthesis downregulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment. Br J Pharmacol (2017) 0.79
Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice. Pharmacol Biochem Behav (2011) 0.78
Non-mammalian models in behavioral neuroscience: consequences for biological psychiatry. Front Behav Neurosci (2015) 0.76
Why may allopregnanolone help alleviate loneliness? Med Hypotheses (2015) 0.75
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14
Neurobiology of depression. Neuron (2002) 8.56
Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. Biol Psychiatry (2006) 5.68
The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry (1965) 5.09
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature (2006) 4.33
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature (1998) 4.09
Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci (2005) 4.07
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci (1999) 2.76
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol (2010) 2.64
Neurosteroids act on recombinant human GABAA receptors. Neuron (1990) 2.44
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Prog Neurobiol (1992) 2.35
Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder. J Abnorm Psychol (1999) 2.34
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci U S A (1998) 2.12
Is mood chemistry? Nat Rev Neurosci (2005) 2.12
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A (2006) 2.01
DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol (2006) 1.95
Neurosteroid access to the GABAA receptor. J Neurosci (2005) 1.95
The thalamic reticular nucleus: structure, function and concept. Brain Res Brain Res Rev (2004) 1.92
The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. Neuropharmacology (2002) 1.85
Neurosteroid modulation of GABAA receptors. Prog Neurobiol (2003) 1.80
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry (2005) 1.74
Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents. Mol Pharmacol (1991) 1.73
Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Life Sci (1991) 1.71
GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am J Psychiatry (2002) 1.56
Rapid regulation of steroidogenesis by mitochondrial protein import. Nature (2002) 1.55
Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J Pharmacol Exp Ther (1988) 1.53
Neurosteroids: beginning of the story. Int Rev Neurobiol (2001) 1.52
Neurosteroids: endogenous allosteric modulators of GABA(A) receptors. Psychoneuroendocrinology (2009) 1.52
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci U S A (1999) 1.51
Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc Natl Acad Sci U S A (2007) 1.51
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology (Berl) (2006) 1.48
History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry (2000) 1.43
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proc Natl Acad Sci U S A (1996) 1.42
Neurosteroid metabolism in the human brain. Eur J Endocrinol (2001) 1.41
Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci U S A (2001) 1.41
Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res (1991) 1.40
Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry (1998) 1.38
Nuclear receptor-mediated transactivation through interaction with Sp proteins. Prog Nucleic Acid Res Mol Biol (2004) 1.34
Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats. J Neurosci (1995) 1.31
Progesterone metabolite allopregnanolone in women with premenstrual syndrome. Obstet Gynecol (1997) 1.31
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology (2009) 1.28
Steroid hormone fluctuations and GABA(A)R plasticity. Psychoneuroendocrinology (2009) 1.27
The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments. Brain Res Brain Res Rev (1997) 1.25
Norepinephrine in depressive reactions. A review. Arch Gen Psychiatry (1965) 1.24
Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther (2000) 1.24
Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology (1999) 1.23
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci U S A (2007) 1.23
Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells. J Biol Chem (2001) 1.22
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proc Natl Acad Sci U S A (2008) 1.22
Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder. Am J Psychiatry (2000) 1.20
Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry (2006) 1.19
The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Res Brain Res Rev (2001) 1.19
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol Sci (2008) 1.17
The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry (2009) 1.15
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol (2009) 1.15
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci U S A (2003) 1.14
On the putative physiological role of allopregnanolone on GABA(A) receptor function. Neuropharmacology (2003) 1.13
Treatment of recent trauma survivors with benzodiazepines: a prospective study. J Clin Psychiatry (1996) 1.12
Mechanisms of anger and treatment outcome in combat veterans with posttraumatic stress disorder. J Trauma Stress (2008) 1.10
Reduced GABAA benzodiazepine receptor binding in veterans with post-traumatic stress disorder. Mol Psychiatry (2007) 1.08
Structure-activity relationships in steroidal anaesthetics. J Steroid Biochem (1975) 1.07
Benzodiazepines on trial: a research strategy for their rehabilitation. Trends Pharmacol Sci (1996) 1.06
Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action. Psychopharmacology (Berl) (2005) 1.05
Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol. Neuropharmacology (2000) 1.03
Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res (2008) 1.03
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J Pharmacol Exp Ther (1992) 1.03
Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat. PLoS One (2010) 1.02
Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability? Biol Psychiatry (1998) 1.01
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). Biochemistry (2002) 1.00
Contextual fear-potentiated startle conditioning in humans: replication and extension. Psychophysiology (2001) 0.99
Serum allopregnanolone in women with postpartum "blues". Obstet Gynecol (2001) 0.98
Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one. Brain Res (1991) 0.97
GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Rev Neurother (2009) 0.96
The complex roles of neurosteroids in depression and anxiety disorders. Neurochem Int (2007) 0.95
The anxiolytic-like effects of allopregnanolone vary as a function of intracerebral microinfusion site: the amygdala, medial prefrontal cortex, or hippocampus. Behav Pharmacol (2007) 0.95
Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci U S A (2004) 0.95
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats. Reproduction (2008) 0.93
Pharmacologic significance of the structural heterogeneity of the GABAA receptor-chloride ion channel complex. Neuropsychopharmacology (1991) 0.93
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action. Steroids (2010) 0.92
Induction of the reelin promoter by retinoic acid is mediated by Sp1. J Neurochem (2007) 0.92
Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc Natl Acad Sci U S A (2006) 0.91
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats. Neuropharmacology (2005) 0.91
Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology (1993) 0.90
Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat. Eur J Pharmacol (2004) 0.90
Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice. Pharmacol Biochem Behav (1998) 0.89
Isolation, aggressiveness and brain 5-hydroxytryptamine turnover. J Pharm Pharmacol (1967) 0.87
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice. Pharmacol Biochem Behav (2007) 0.87
Pharmacological management of post-traumatic stress disorder: clinical summary of a five-year retrospective study, 1990-1995. Mil Med (1997) 0.87
Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.85
S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology (2010) 0.85
Allopregnanolone microinjected into the lateral septum or dorsal hippocampus reduces immobility in the forced swim test: participation of the GABAA receptor. Behav Pharmacol (2009) 0.85
Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. J Clin Psychiatry (2004) 0.85
Dopamine is involved in the antidepressant-like effect of allopregnanolone in the forced swimming test in female rats. Behav Pharmacol (2010) 0.84
Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems. Pharmacol Biochem Behav (2003) 0.84
Neurosteroids and neuroactive drugs in mental disorders. Life Sci (2004) 0.84
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. J Pharmacol Exp Ther (1993) 0.84
Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: Behavioral and immunocytochemical evidences. Brain Res (2010) 0.83