Published in Nat Rev Neurosci on May 01, 2007
The molecular neurobiology of depression. Nature (2008) 6.51
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci (2010) 5.12
Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci (2009) 4.53
Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry (2009) 4.12
Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci (2008) 3.86
Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci (2008) 3.72
Psychobiology and molecular genetics of resilience. Nat Rev Neurosci (2009) 3.71
Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov (2009) 3.50
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci (2011) 3.27
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17
Review. Transcriptional mechanisms of addiction: role of DeltaFosB. Philos Trans R Soc Lond B Biol Sci (2008) 3.00
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet (2011) 2.99
Early life programming and neurodevelopmental disorders. Biol Psychiatry (2010) 2.93
Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 2.76
Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54
Long non-coding RNAs in nervous system function and disease. Brain Res (2010) 2.53
Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci (2008) 2.45
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS One (2008) 2.40
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol (2008) 2.40
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol (2008) 2.29
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet (2012) 2.20
Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med (2011) 2.17
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
Epigenetic mechanisms in drug addiction. Trends Mol Med (2008) 2.14
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci (2009) 2.11
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci U S A (2010) 2.06
Tackling the epigenome: challenges and opportunities for collaboration. Nat Biotechnol (2010) 2.04
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett (2012) 2.04
Isolation of neuronal chromatin from brain tissue. BMC Neurosci (2008) 2.02
A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron (2011) 1.92
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
Regulation of hippocampal H3 histone methylation by acute and chronic stress. Proc Natl Acad Sci U S A (2009) 1.72
Genetic approaches to addiction: genes and alcohol. Addiction (2008) 1.70
Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc (2011) 1.66
Epigenetics in the nervous system. J Neurosci (2008) 1.65
Genome-wide association scan of trait depression. Biol Psychiatry (2010) 1.65
Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. J Neurosci (2011) 1.62
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res (2011) 1.61
Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS One (2011) 1.58
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res (2011) 1.57
The genetics of bipolar disorder. Neuroscience (2009) 1.57
The Emerging Field of Human Social Genomics. Clin Psychol Sci (2013) 1.57
Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PLoS One (2009) 1.53
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Neurobiological mechanisms in major depressive disorder. CMAJ (2009) 1.49
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr Bull (2008) 1.49
Epigenetic regulation in human brain-focus on histone lysine methylation. Biol Psychiatry (2008) 1.48
Mechanisms of stress in the brain. Nat Neurosci (2015) 1.47
Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology (2009) 1.46
Novel methylation markers of the dysexecutive-psychiatric phenotype in FMR1 premutation women. Neurology (2015) 1.45
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. J Neurosci (2008) 1.42
Oxidative stress in schizophrenia: an integrated approach. Neurosci Biobehav Rev (2010) 1.38
Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond. Pharmacol Biochem Behav (2008) 1.36
Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci (2009) 1.32
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry (2012) 1.31
A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories. PLoS One (2013) 1.30
Does the concept of "sensitization" provide a plausible mechanism for the putative link between the environment and schizophrenia? Schizophr Bull (2008) 1.27
Ionotropic glutamate receptors & CNS disorders. CNS Neurol Disord Drug Targets (2008) 1.27
Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biol Psychiatry (2012) 1.26
Histone acetylation in drug addiction. Semin Cell Dev Biol (2009) 1.24
Bipolar disorder: from genes to behavior pathways. J Clin Invest (2009) 1.24
The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. Mol Pharmacol (2008) 1.22
Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biol Psychiatry (2009) 1.21
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
DNA methylation impacts on learning and memory in aging. Neurobiol Aging (2007) 1.20
Understanding resilience. Front Behav Neurosci (2013) 1.19
Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory. Learn Mem (2011) 1.19
Activating positive memory engrams suppresses depression-like behaviour. Nature (2015) 1.19
Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. Alcohol Clin Exp Res (2011) 1.18
Epigenetic mechanisms of drug addiction. Neuropharmacology (2013) 1.17
15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet (2011) 1.17
Epigenetic mechanisms in schizophrenia. Biochim Biophys Acta (2009) 1.17
Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development. J Child Psychol Psychiatry (2011) 1.16
Behavioral epigenetics. Ann N Y Acad Sci (2011) 1.14
Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol (2010) 1.14
Balancing histone methylation activities in psychiatric disorders. Trends Mol Med (2011) 1.14
Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry (2013) 1.12
Calcium signaling in synapse-to-nucleus communication. Cold Spring Harb Perspect Biol (2011) 1.12
Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Transl Psychiatry (2013) 1.11
Creating nurturing environments: a science-based framework for promoting child health and development within high-poverty neighborhoods. Clin Child Fam Psychol Rev (2011) 1.10
Personalized medicine in psychiatry: problems and promises. BMC Med (2013) 1.09
Prenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats. PLoS One (2008) 1.08
Scrutinizing the epigenetics revolution. Biosocieties (2014) 1.08
Epigenetics in the human brain. Neuropsychopharmacology (2012) 1.08
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem (2011) 1.07
Depression research: where are we now? Mol Brain (2010) 1.06
Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nat Neurosci (2015) 1.06
From synapse to nucleus: novel targets for treating depression. Neuropharmacology (2009) 1.06
The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. Psychopharmacology (Berl) (2010) 1.06
Epigenetic treatments for cognitive impairments. Neuropsychopharmacology (2011) 1.05
Co-clustering phenome-genome for phenotype classification and disease gene discovery. Nucleic Acids Res (2012) 1.05
Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science (2006) 9.31
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24
The molecular neurobiology of depression. Nature (2008) 6.51
The many faces of CREB. Trends Neurosci (2005) 5.58
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci (2006) 4.62
Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci (2003) 4.60
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Psychobiology and molecular genetics of resilience. Nat Rev Neurosci (2009) 3.71
Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci (2011) 3.69
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci (2010) 3.47
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A (2004) 3.37
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A (2002) 3.32
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
The brain reward circuitry in mood disorders. Nat Rev Neurosci (2013) 3.08
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci (2010) 3.02
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97
CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci (2006) 2.95
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Early life programming and neurodevelopmental disorders. Biol Psychiatry (2010) 2.93
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci (2006) 2.71
DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res (2004) 2.67
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64
RGS9 modulates dopamine signaling in the basal ganglia. Neuron (2003) 2.61
Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54
Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry (2003) 2.37
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry (2006) 2.36
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A (2010) 2.36
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34
Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci (2004) 2.30
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci (2006) 2.29
Induction of deltaFosB in reward-related brain structures after chronic stress. J Neurosci (2004) 2.27
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25
Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci (2002) 2.21
Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci (2012) 2.20
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci (2009) 2.18
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A (2010) 2.17
An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci (2006) 2.17
Molecular neurobiology of drug addiction. Annu Rev Med (2004) 2.16
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci (2003) 2.16
Epigenetic mechanisms in drug addiction. Trends Mol Med (2008) 2.14
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Neurobiology of resilience. Nat Neurosci (2012) 2.13
The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem (2002) 2.13
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci (2009) 2.11
Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A (2003) 2.08
Paternal transmission of stress-induced pathologies. Biol Psychiatry (2011) 2.07
Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology (2007) 2.04
Neurotrophic factors and structural plasticity in addiction. Neuropharmacology (2008) 1.99
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci (2005) 1.95
Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr (2009) 1.95
A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron (2011) 1.92
Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci (2003) 1.89
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci (2002) 1.89
Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. Genome Biol (2014) 1.88
The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. Front Neuroanat (2011) 1.87
The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci (2005) 1.86
Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci (2005) 1.84
Delta FosB regulates wheel running. J Neurosci (2002) 1.80
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry (2003) 1.78
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci (2002) 1.77
Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci (2008) 1.76
qDTY₁.₁, a major QTL for rice grain yield under reproductive-stage drought stress with a consistent effect in multiple elite genetic backgrounds. BMC Genet (2011) 1.76
Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J Neurosci (2010) 1.75
DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci (2007) 1.74
Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci U S A (2011) 1.69
A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci (2011) 1.68