Published in BMC Cancer on August 20, 2010
Unfolded protein response to autophagy as a promising druggable target for anticancer therapy. Ann N Y Acad Sci (2012) 1.21
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis. Front Genet (2013) 0.89
Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol. Int J Nanomedicine (2012) 0.89
Tumor progression and the different faces of the PERK kinase. Oncogene (2015) 0.80
The unfolded protein response in human corneal endothelial cells following hypothermic storage: implications of a novel stress pathway. Cryobiology (2011) 0.80
Characterization and modulation of human mesenchymal stem cell stress pathway response following hypothermic storage. Cryobiology (2014) 0.78
Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1. Exp Mol Med (2016) 0.77
Modulation of Inflammatory Response and Induction of Bone Formation Based on Combinatorial Effects of Resveratrol. J Nanomed Nanotechnol (2016) 0.75
Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells. J Invest Dermatol (2013) 0.75
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86
Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell (2000) 11.09
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 10.90
Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell (2001) 8.60
Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest (2005) 8.45
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol (2001) 8.03
Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69
Orchestrating the unfolded protein response in health and disease. J Clin Invest (2002) 7.60
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol (2000) 5.73
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol (2001) 5.08
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res (2004) 4.69
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85
Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ (2006) 3.50
Does autophagy contribute to cell death? Autophagy (2005) 3.21
PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A (2000) 2.87
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol (2007) 2.65
IRE1 and efferent signaling from the endoplasmic reticulum. J Cell Sci (2000) 2.46
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci U S A (1999) 2.35
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol (2009) 1.94
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res (2001) 1.93
Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem (2005) 1.84
Resveratrol: from grapevines to mammalian biology. FASEB J (2003) 1.80
Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr (2000) 1.69
PHYTOALEXINS: What Have We Learned After 60 Years? Annu Rev Phytopathol (1999) 1.63
ER stress signaling by regulated proteolysis of ATF6. Methods (2005) 1.61
A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis (2001) 1.49
Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res (2000) 1.43
Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res (2007) 1.37
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family. Oncogene (2003) 1.22
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J (2001) 1.21
Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J Nutr (2002) 1.19
Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett (2005) 1.18
Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol. FASEB J (2008) 1.17
Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Carcinogenesis (2002) 1.11
Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Cancer Detect Prev (2006) 1.05
Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. Biochem Pharmacol (2006) 0.95
Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem Pharmacol (2007) 0.92
The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells. Exp Cell Res (2008) 0.91
A novel resveratrol derivative, HS1793, overcomes the resistance conferred by Bcl-2 in human leukemic U937 cells. Biochem Pharmacol (2009) 0.90
Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70. Cancer Sci (2008) 0.87
Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol. J Mol Neurosci (2009) 0.87
Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol Res (2004) 0.83
Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells. Cancer Res (2003) 0.83
Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells. Biochem Pharmacol (2008) 0.79
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. J Virol (2006) 1.42
Characteristics of stem cells derived from the degenerated human intervertebral disc cartilage endplate. PLoS One (2011) 1.22
Identification of structural proteins from shrimp white spot syndrome virus (WSSV) by 2DE-MS. Proteins (2004) 1.14
Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1. J Cell Physiol (2009) 1.12
Is sunlight exposure a risk factor for age-related macular degeneration? A systematic review and meta-analysis. Br J Ophthalmol (2012) 1.02
Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression. Br J Pharmacol (2009) 0.99
Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells. BMC Cancer (2009) 0.98
BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells. Autophagy (2013) 0.96
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem (2005) 0.96
Drug releasing behavior of hybrid micelles containing polypeptide triblock copolymer. Biomaterials (2008) 0.96
Involvement of glyceraldehyde-3-phosphate dehydrogenase in tumor necrosis factor-related apoptosis-inducing ligand-mediated death of thyroid cancer cells. Endocrinology (2007) 0.93
Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation. Biochem Biophys Res Commun (2009) 0.93
BAG3 is upregulated by c-Jun and stabilizes JunD. Biochim Biophys Acta (2013) 0.92
TNF-related apoptosis-inducing ligand suppresses PRDX4 expression. FEBS Lett (2009) 0.92
Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model. Spine (Phila Pa 1976) (2011) 0.92
Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma. Clin Exp Med (2009) 0.92
The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats. Brain Res (2012) 0.90
Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes. World J Gastroenterol (2013) 0.90
Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors. BMC Cancer (2012) 0.88
SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. World J Gastroenterol (2011) 0.86
Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells. Biochem Biophys Res Commun (2008) 0.86
BAG3 promoted starvation-induced apoptosis of thyroid cancer cells via attenuation of autophagy. J Clin Endocrinol Metab (2014) 0.85
Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells. Exp Cell Res (2011) 0.84
Altered motor network functional connectivity in amyotrophic lateral sclerosis: a resting-state functional magnetic resonance imaging study. Neuroreport (2013) 0.83
Construction of collagen II/hyaluronate/chondroitin-6-sulfate tri-copolymer scaffold for nucleus pulposus tissue engineering and preliminary analysis of its physico-chemical properties and biocompatibility. J Mater Sci Mater Med (2009) 0.83
BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78. Biochim Biophys Acta (2013) 0.82
Implication of oxygen-regulated protein 150 (ORP150) in apoptosis induced by proteasome inhibitors in human thyroid cancer cells. J Clin Endocrinol Metab (2010) 0.81
Beclin 1 enhances proteasome inhibition-mediated cytotoxicity of thyroid cancer cells in macroautophagy-independent manner. J Clin Endocrinol Metab (2012) 0.81
Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells. Biochim Biophys Acta (2012) 0.81
Proteasome inhibition induces a p38 MAPK pathway-dependent antiapoptotic program via Nrf2 in thyroid cancer cells. J Clin Endocrinol Metab (2011) 0.81
Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells. J Cell Physiol (2010) 0.81
Study to determine the presence of progenitor cells in the degenerated human cartilage endplates. Eur Spine J (2011) 0.81
Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells. Endocr Relat Cancer (2010) 0.80
Comparison of a multiple daily insulin injection regimen (glargine or detemir once daily plus prandial insulin aspart) and continuous subcutaneous insulin infusion (aspart) in short-term intensive insulin therapy for poorly controlled type 2 diabetes patients. Int J Endocrinol (2013) 0.80
Implication of 14-3-3ε and 14-3-3θ/τ in proteasome inhibition-induced apoptosis of glioma cells. Cancer Sci (2012) 0.80
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation. J Neurochem (2004) 0.80
Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes Cells (2006) 0.79
Glucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell. Exp Mol Med (2011) 0.79
Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1. BMC Cancer (2011) 0.78
Synergistic anti-tumor effect of KLF4 and curcumin in human gastric carcinoma cell line. Asian Pac J Cancer Prev (2014) 0.78
Advanced glycation end products promote proliferation and suppress autophagy via reduction of Cathepsin D in rat vascular smooth muscle cells. Mol Cell Biochem (2015) 0.78
Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin. Exp Mol Med (2009) 0.77
[Clinical practice and evaluation of relative fluid resuscitation formula at burn shock stage]. Zhonghua Shao Shang Za Zhi (2008) 0.77
Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. Endocr Relat Cancer (2008) 0.77
Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats. Exp Lung Res (2012) 0.77
[Effects of histone deacetylase inhibitor on the expression of angiogenesis related factors in Kasumi-1 leukemic cell line]. Zhonghua Xue Ye Xue Za Zhi (2010) 0.77
Mutational analysis of the müllerian-inhibiting substance gene and its receptor gene in Japanese women with polycystic ovary syndrome and premature ovarian failure. Fertil Steril (2002) 0.77
[Inhibitory effect of valproic acid on xenografted Kasumi-1 tumor growth in nude mouse and its mechanism]. Zhonghua Xue Ye Xue Za Zhi (2011) 0.76
Protein S gene mutation in a young woman with type III protein S deficiency and venous thrombosis during pregnancy. J Thromb Thrombolysis (2002) 0.76
Spinal tuberculosis occurring after a closed bursting fracture of the vertebrae. Eur Spine J (2012) 0.75
Simultaneous determination of ciclesonide and its active metabolite desisobutyryl-ciclesonide in human plasma by LC-APCI-MS/MS: application to pharmacokinetic study in healthy Chinese volunteers. J Pharm Biomed Anal (2011) 0.75
[Association of sub-health symptoms with family environment factors in middle school students in Bengbu District]. Wei Sheng Yan Jiu (2010) 0.75
[Relation between sub-health and family environmental factors among university students in Bengbu city]. Wei Sheng Yan Jiu (2010) 0.75
A single-strand helical coordination polymer: catena-poly[[[triaquanickel(II)]-mu-2,2'-bipyridine-3,3'-dicarboxylato-kappa(3)N,N':O] monohydrate]. Acta Crystallogr C (2003) 0.75
[Degenerate oligonucleotide primed-PCR technology establishment and its sensitivity test analysis]. Fa Yi Xue Za Zhi (2012) 0.75
Effects of chronic exposure to Aspergillus fumigatus on epidermal growth factor receptor expression in the airway epithelial cells of asthmatic rats. Exp Lung Res (2014) 0.75
[A clinical study of fungal infection in burn patients]. Zhonghua Shao Shang Za Zhi (2009) 0.75