Published in Proc Natl Acad Sci U S A on July 20, 1999
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood (2006) 5.21
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev (2004) 2.94
PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A (2000) 2.87
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res (2006) 2.15
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell (2005) 1.88
The STT3a subunit isoform of the Arabidopsis oligosaccharyltransferase controls adaptive responses to salt/osmotic stress. Plant Cell (2003) 1.79
Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta (2008) 1.67
Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus. Proc Natl Acad Sci U S A (2008) 1.63
Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome. Crit Care Med (2008) 1.56
The exosome complex establishes a barricade to erythroid maturation. Blood (2014) 1.48
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res (2009) 1.44
Endoplasmic reticulum stress is a determinant of retrovirus-induced spongiform neurodegeneration. J Virol (2003) 1.43
Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1. Proc Natl Acad Sci U S A (2008) 1.31
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Sci Signal (2016) 1.29
Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle (2006) 1.19
The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell (2007) 1.16
Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation. PLoS One (2007) 1.14
Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. Cancer Res (2008) 1.13
The cell biology of the unfolded protein response. Gastroenterology (2011) 1.11
Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Mol Biol Cell (2008) 1.09
The canine papillomavirus e5 protein signals from the endoplasmic reticulum. J Virol (2009) 1.05
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. Arterioscler Thromb Vasc Biol (2013) 1.05
Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts. Mol Cell Biol (2004) 1.03
Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1. Cell Microbiol (2007) 1.03
Unfolded protein response followed by induction of cell death in cultured tobacco cells treated with tunicamycin. Planta (2005) 1.00
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood (2008) 1.00
A mutation in GDP-mannose pyrophosphorylase causes conditional hypersensitivity to ammonium, resulting in Arabidopsis root growth inhibition, altered ammonium metabolism, and hormone homeostasis. J Exp Bot (2009) 0.98
The mammalian endoplasmic reticulum as a sensor for cellular stress. Cell Stress Chaperones (2002) 0.97
Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertens (2011) 0.97
PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol (2012) 0.97
C/EBP-beta regulates endoplasmic reticulum stress-triggered cell death in mouse and human models. PLoS One (2010) 0.97
Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. J Biol Chem (2011) 0.96
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Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells. BMC Cancer (2008) 0.92
Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci (2010) 0.92
Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma. J Cell Mol Med (2014) 0.92
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New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases. Int J Hepatol (2014) 0.90
Small-Molecule targeting of translation initiation for cancer therapy. Oncotarget (2013) 0.89
Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer? Cancer Cell (2014) 0.89
Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proc Natl Acad Sci U S A (2011) 0.89
The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res (2014) 0.89
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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One (2012) 0.88
Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response. Biochem J (2007) 0.88
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress. Cancer Res (2009) 0.87
Measurement of hepatic protein fractional synthetic rate with stable isotope labeling technique in thapsigargin stressed HepG2 cells. Int J Biol Sci (2012) 0.87
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. BMC Cancer (2010) 0.87
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress. J Biol Chem (2013) 0.86
PRDM1 is required for mantle cell lymphoma response to bortezomib. Mol Cancer Res (2010) 0.86
Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep (2006) 0.85
The unfolded protein response in lung disease. Proc Am Thorac Soc (2010) 0.85
CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination. J Biol Chem (2009) 0.84
Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling. Oncotarget (2013) 0.84
Examination of a second node of translational control in the unfolded protein response. J Cell Sci (2013) 0.83
Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol (2011) 0.82
PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development. J Cell Physiol (2016) 0.82
Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. J Biol Chem (2012) 0.81
Molecular pathways: the PERKs and pitfalls of targeting the unfolded protein response in cancer. Clin Cancer Res (2014) 0.81
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Br J Pharmacol (2014) 0.80
Tumor progression and the different faces of the PERK kinase. Oncogene (2015) 0.80
Stress signaling and the shaping of the mammary tissue in development and cancer. Oncogene (2014) 0.79
New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells. PLoS One (2013) 0.78
Association of cyclin D and estrogen receptor α36 with hepatocellular adenomas of female mice under chronic endoplasmic reticulum stress. J Gastroenterol Hepatol (2013) 0.78
UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels. PLoS One (2012) 0.78
Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.78
Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin. Exp Mol Med (2009) 0.77
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress. Lipids Health Dis (2011) 0.77
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. BMC Cell Biol (2009) 0.77
The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. PLoS One (2012) 0.77
Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl) (2016) 0.76
Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. Int J Oncol (2015) 0.76
Balancing life with glycoconjugates: monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman Spectroscopy. Pure Appl Chem (2012) 0.76
The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila) (2013) 0.76
The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence. Sci Rep (2016) 0.76
Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress. World J Gastroenterol (2006) 0.76
Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Sci Rep (2016) 0.75
TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis. Mol Cell Biol (2015) 0.75
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet (2016) 0.75
Maintaining the Factory: The Roles of the Unfolded Protein Response in Cellular Homeostasis in Plants. Plant J (2016) 0.75
The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells. Nucleic Acids Res (2015) 0.75
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. ACS Chem Biol (2016) 0.75
Lack of XBP-1 impedes murine cytomegalovirus gene expression. PLoS One (2014) 0.75
Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer. Mol Oncol (2016) 0.75
Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther (2014) 0.75
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation. Oncotarget (2017) 0.75
Accumulation of prohibitin is a common cellular response to different stressing stimuli and protects melanoma cells from ER stress and chemotherapy-induced cell death. Oncotarget (2017) 0.75
Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics. Pharmaceuticals (Basel) (2017) 0.75
Mammalian ECD protein is a novel negative regulator of the PERK arm of unfolded protein response. Mol Cell Biol (2017) 0.75
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