Published in Cell Cycle on August 17, 2010
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget (2012) 1.96
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 1.85
Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis. Int J Mol Sci (2013) 1.28
The pathoetiology of neurofibromatosis 1. Am J Pathol (2011) 1.13
Genetic polymorphisms in RNA binding proteins contribute to breast cancer survival. Int J Cancer (2012) 0.88
Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells. Mol Cancer (2012) 0.88
Micro-RNAs as clinical biomarkers and therapeutic targets in breast cancer: Quo vadis? World J Clin Oncol (2014) 0.87
Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2. Mol Cell Biol (2014) 0.86
Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells. Oncotarget (2015) 0.81
Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms. J Biol Chem (2014) 0.81
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis. J Immunol (2013) 0.81
The flip-flop HuR: part of the problem or the solution in fighting cancer? J Clin Invest (2011) 0.80
Conditional knockout of the RNA-binding protein HuR in CD4⁺ T cells reveals a gene dosage effect on cytokine production. Mol Med (2014) 0.80
Method for the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts using RIP-Chip. J Vis Exp (2012) 0.79
Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells. PLoS One (2015) 0.78
Incisional hernia recurrence through genomic profiling: a pilot study. Hernia (2012) 0.76
Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment. Neoplasia (2016) 0.75
Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev (2016) 0.75
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
The hallmarks of cancer. Cell (2000) 113.05
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res (2005) 22.62
lumi: a pipeline for processing Illumina microarray. Bioinformatics (2008) 17.19
Using GOstats to test gene lists for GO term association. Bioinformatics (2006) 12.58
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics (2006) 11.33
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J (1998) 7.62
Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem (1996) 5.82
Triple negative tumours: a critical review. Histopathology (2008) 4.94
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem (1998) 4.57
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell (2002) 4.39
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J (2000) 4.11
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci U S A (1999) 3.61
ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J Cell Sci (1998) 2.83
Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene (2003) 2.69
miR-519 suppresses tumor growth by reducing HuR levels. Cell Cycle (2010) 2.63
Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer--a quantitative western blot analysis. Ann Neurol (1990) 2.58
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome. Proc Natl Acad Sci U S A (2001) 2.51
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
Mechanisms of microRNA deregulation in human cancer. Cell Cycle (2008) 2.30
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle (2007) 2.25
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
The AU-rich transcriptome: more than interferons and cytokines, and its role in disease. J Interferon Cytokine Res (2005) 2.09
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol (1999) 1.99
Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res (2005) 1.94
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure. Chembiochem (2004) 1.82
HuR in the mammalian genotoxic response: post-transcriptional multitasking. Cell Cycle (2003) 1.80
Regulation of tumor angiogenesis by thrombospondin-1. Biochim Biophys Acta (2005) 1.76
RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation. J Biol Chem (2003) 1.51
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene (2008) 1.41
Prognostic role of HuR in hereditary breast cancer. Clin Cancer Res (2007) 1.41
Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Neurology (1991) 1.26
Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int J Cancer (2007) 1.18
Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Cancer Biol Ther (2008) 1.18
siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo. J Hepatol (2008) 1.14
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer (2010) 1.10
A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR. J Biol Chem (2002) 1.10
AU-rich transient response transcripts in the human genome: expressed sequence tag clustering and gene discovery approach. Genomics (2005) 1.09
A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models. PLoS One (2010) 1.08
Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther (2007) 1.02
Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins. Trends Cardiovasc Med (1998) 0.98
HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence. Carcinogenesis (2008) 0.97
Organizing mRNA export. Nat Genet (2003) 0.91
Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model. Breast Cancer Res Treat (2008) 0.88
Posttranscriptional generation of macromolecular complexes. Mol Cell (2003) 0.86
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34
Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Res (2007) 3.40
Circulating microRNAs in breast cancer and healthy subjects. BMC Res Notes (2009) 2.78
Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Cancer Res (2002) 2.55
Synthetic cannabinoid intoxication: a case series and review. J Emerg Med (2012) 2.46
Traditional Chinese medicine in cancer care: a review of case reports published in Chinese literature. Forsch Komplementmed (2011) 1.96
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis. Gut (2012) 1.86
[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci U S A (2007) 1.73
Colonic sterilization for natural orifice translumenal endoscopic surgery (NOTES) procedures: a comparison of two decontamination protocols. Surg Endosc (2009) 1.73
Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response. Hepatology (2011) 1.70
Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia. Cancer Res (2007) 1.58
In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med (2007) 1.52
Melanoma therapy via peptide-targeted {alpha}-radiation. Clin Cancer Res (2005) 1.52
Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. Am J Physiol Endocrinol Metab (2007) 1.46
Flavivirus capsid is a dimeric alpha-helical protein. J Virol (2003) 1.43
A wild-type porcine encephalomyocarditis virus containing a short poly(C) tract is pathogenic to mice, pigs, and cynomolgus macaques. J Virol (2003) 1.41
Sentinel node mapping during laparoscopic distal gastrectomy for gastric cancer. Surg Endosc (2008) 1.38
Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: an international multicenter cohort study. J Hepatol (2011) 1.36
Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. Hypertension (2010) 1.32
Site-directed mutagenesis by combination of homologous recombination and DpnI digestion of the plasmid template in Escherichia coli. Anal Biochem (2007) 1.24
Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol (2011) 1.24
Linking clinic patients to Internet-based, condition-specific information prescriptions. J Med Libr Assoc (2010) 1.21
Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation. J Immunol (2008) 1.20
Prediction of the pharmacodynamically linked variable of oseltamivir carboxylate for influenza A virus using an in vitro hollow-fiber infection model system. Antimicrob Agents Chemother (2009) 1.20
Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides. Cancer Biother Radiopharm (2005) 1.18
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer (2010) 1.10
Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol (2011) 1.09
Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging. Am J Physiol Heart Circ Physiol (2010) 1.09
In vitro and in vivo analysis of [(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors. Nucl Med Biol (2009) 1.07
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women. Fertil Steril (2009) 1.04
Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression. Am J Physiol Heart Circ Physiol (2011) 1.02
Large-scale analysis of DNA methylation in chronic lymphocytic leukemia. Epigenomics (2009) 1.02
Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. Am J Physiol Heart Circ Physiol (2012) 1.01
Microimaging characterization of a B16-F10 melanoma metastasis mouse model. Mol Imaging (2006) 1.01
In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys). Bioconjug Chem (2007) 1.00
Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model. Bioconjug Chem (2008) 0.99
Early depression of Ankrd2 and Csrp3 mRNAs in the polyribosomal and whole tissue fractions in skeletal muscle with decreased voluntary running. J Appl Physiol (1985) (2012) 0.99
Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. Endocrinology (2012) 0.99
British HIV Association guidelines for the management of hepatitis viruses in adults infected with HIV 2013. HIV Med (2013) 0.98
Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region. Endocrinology (2013) 0.96
Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases. Prostate (2012) 0.95
Subunit-subunit interactions in the human 26S proteasome. Proteomics (2008) 0.95
Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector. Bioconjug Chem (2008) 0.95
High-throughput cloning of human liver complete open reading frames using homologous recombination in Escherichia coli. Anal Biochem (2009) 0.94
In vitro and in vivo evaluation of Alexa Fluor 680-bombesin[7-14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor. Mol Imaging (2007) 0.94
Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists, [64Cu-NO2A-(X)-BBN(7-14)NH2], in a prostate tumor xenografted mouse model. Nucl Med Biol (2010) 0.94
A retrospective study of mortality in Pennsylvania captive white-tailed deer (Odocoileus virginianus): 20000--2003. J Vet Diagn Invest (2004) 0.93
TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem (2010) 0.93
Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera. Gene (2003) 0.92
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity. Histol Histopathol (2009) 0.92
Proteomic mapping of proteins released during necrosis and apoptosis from cultured neonatal cardiac myocytes. Am J Physiol Cell Physiol (2014) 0.92
Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol (2011) 0.91
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. J Mol Cell Cardiol (2012) 0.91
Noninvasive detection of inflammation-associated colon cancer in a mouse model. Neoplasia (2010) 0.91
The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR. J Cell Biochem (2006) 0.91
Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res (2010) 0.91
Evaluation of combined (177)Lu-DOTA-8-AOC-BBN (7-14)NH(2) GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice. Cancer Biother Radiopharm (2006) 0.90
Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity. J Appl Physiol (1985) (2014) 0.89
Time to internal fixation of femoral neck fractures in patients under sixty years--does this matter in the development of osteonecrosis of femoral head? Int Orthop (2012) 0.89
Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice. BMC Neurosci (2014) 0.89
Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat. Am J Physiol Heart Circ Physiol (2009) 0.88
Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model. Breast Cancer Res Treat (2008) 0.88
Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis. Am J Physiol Heart Circ Physiol (2011) 0.88
64Cu-NO2A-RGD-Glu-6-Ahx-BBN(7-14)NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer. Nucl Med Biol (2012) 0.87
Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. Physiol Genomics (2013) 0.87
Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity. J Appl Physiol (1985) (2014) 0.87
Liver transplantation for hepatocellular carcinoma. World J Gastroenterol (2009) 0.86
The SUMOylation of zinc-fingers and homeoboxes 1 (ZHX1) by Ubc9 regulates its stability and transcriptional repression activity. J Cell Biochem (2013) 0.86
Gastrotomy creation and closure for NOTES using a gastropexy technique (with video). Gastrointest Endosc (2008) 0.86
Large group high-fidelity simulation enhances medical student learning. Med Teach (2009) 0.85
Pm-149 DOTA bombesin analogs for potential radiotherapy. in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amide-betaAla-BBN(7-14)NH(2). Nucl Med Biol (2002) 0.85
Organometallic 99mTc(III) '4 + 1' bombesin(7-14) conjugates: synthesis, radiolabeling, and in vitro/in vivo studies. Bioconjug Chem (2007) 0.85
Isolation of avian pneumovirus from mallard ducks that is genetically similar to viruses isolated from neighboring commercial turkeys. Virus Res (2002) 0.85
Cloning and enzymatic characterization of a xylanase gene from a soil-derived metagenomic library with an efficient approach. Appl Microbiol Biotechnol (2008) 0.85
Increased expression of the inflammatory protein YKL-40 in precancers of the breast. Int J Cancer (2007) 0.85
NMR relaxation studies of an RNA-binding segment of the rous sarcoma virus gag polyprotein in free and bound states: a model for autoinhibition of assembly. Biochemistry (2010) 0.85
Endoscopic colotomy closure for natural orifice transluminal endoscopic surgery using a T-fastener prototype in comparison to conventional laparoscopic suture closure. Gastrointest Endosc (2008) 0.85
Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour Biol (2014) 0.84
The effects of linking substituents on the in vivo behavior of site-directed, peptide-based, diagnostic radiopharmaceuticals. In Vivo (2007) 0.84
Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] conjugates for targeting gastrin-releasing peptide receptors overexpressed on breast carcinoma. Anticancer Res (2010) 0.84
Bombesin analogues for gastrin-releasing peptide receptor imaging. Nucl Med Biol (2012) 0.83
The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. J Nutr (2008) 0.83
Discrete nanomolecular polyhedral borane scaffold supporting multiple gadolinium(III) complexes as a high performance MRI contrast agent. Inorg Chem (2012) 0.83
Pyrazolyl conjugates of bombesin: a new tridentate ligand framework for the stabilization of fac-[M(CO)3]+ moiety. Nucl Med Biol (2006) 0.82
Human metapneumovirus in turkey poults. Emerg Infect Dis (2006) 0.82
Investigation of H7N2 avian influenza outbreaks in two broiler breeder flocks in Pennsylvania, 2001-02. Avian Dis (2004) 0.82
Synthesis and in vitro evaluation of a rhenium-cyclized somatostatin derivative series. J Med Chem (2008) 0.82
Autofluorescence spectrum of skin: component bands and body site variations. Skin Res Technol (2000) 0.82
99mTc(CO)3-DTMA bombesin conjugates having high affinity for the GRP receptor. Nucl Med Biol (2008) 0.82
Efficient vectors for expression cloning of large numbers of PCR fragments in P. pastoris. Yeast (2010) 0.81