Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

PubWeight™: 0.88‹?›

🔗 View Article (PMC 3016607)

Published in Oncogene on August 23, 2010

Authors

S Radulescu1, R A Ridgway, P Appleton, K Kroboth, S Patel, J Woodgett, S Taylor, I S Nathke, O J Sansom

Author Affiliations

1: CR-UK Beatson Institute of Cancer Research, Glasgow, UK.

Articles citing this

Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44

APC selectively mediates response to chemotherapeutic agents in breast cancer. BMC Cancer (2015) 1.39

E-cadherin can limit the transforming properties of activating β-catenin mutations. EMBO J (2015) 0.94

More than two decades of Apc modeling in rodents. Biochim Biophys Acta (2013) 0.91

APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation. Development (2013) 0.88

MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell (2015) 0.88

Cell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines. Cancer Cell Int (2013) 0.87

MicroRNAs: key players of taxane resistance and their therapeutic potential in human cancers. J Cell Mol Med (2013) 0.81

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. J Cell Sci (2012) 0.80

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease. Oncotarget (2016) 0.76

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis. Biochim Biophys Acta (2015) 0.75

Insulin signaling regulates a functional interaction between Adenomatous Polyposis Coli (APC) and cytoplasmic dynein. Mol Biol Cell (2017) 0.75

Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone. Mutagenesis (2017) 0.75

Articles cited by this

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90

High-resolution model of the microtubule. Cell (1999) 9.04

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell (2008) 6.62

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66

Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42

Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol (2001) 4.90

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62

A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol (2001) 4.18

Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09

APC binds to the novel protein EB1. Cancer Res (1995) 3.98

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39

Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint". J Cell Biol (2004) 2.34

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell (2005) 2.14

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci (2004) 2.09

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Mol Cell Biol (2008) 2.03

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol (2007) 1.77

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J (2006) 1.76

Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res (2003) 1.75

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell (2007) 1.72

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol (2007) 1.60

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell (2006) 1.50

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat Genet (2008) 1.50

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity. Nucleic Acids Res (2004) 1.43

c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A (2005) 1.35

The adenomatous polyposis coli protein: in the limelight out at the edge. Trends Cell Biol (2001) 1.33

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell (2004) 1.25

Original CIN: reviewing roles for APC in chromosome instability. J Cell Biol (2008) 1.10

MDR1/P-glycoprotein expression in colorectal cancer. Eur J Cancer (1995) 0.97

Vinorelbine (Navelbine). A new semisynthetic vinca alkaloid. Onkologie (1991) 0.91

Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death. Cell Motil Cytoskeleton (2001) 0.81

Articles by these authors

Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ (1999) 6.40

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A (1998) 5.98

Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann Intern Med (1992) 4.81

Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (2006) 4.23

The natural history of asthma in childhood. J Epidemiol Community Health (1986) 4.09

2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor. Bioorg Med Chem Lett (2000) 4.03

Human herpesvirus 8 variants in sarcoid tissues. Lancet (1997) 3.87

Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age. Lancet (1992) 3.60

Comparison of percutaneous and surgical tracheostomies. Chest (1996) 3.56

Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A (1999) 3.42

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors. Nat Med (1999) 3.39

Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arterioscler Thromb Vasc Biol (2001) 3.38

Cardiovascular risk factors in British children from towns with widely differing adult cardiovascular mortality. BMJ (1996) 3.14

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol (1998) 3.12

Comparison of diameter and perimeter methods for tumor volume calculation. J Clin Oncol (2001) 3.09

Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain. Nature (1985) 3.08

Math5 is required for retinal ganglion cell and optic nerve formation. Development (2001) 3.07

Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. Arch Gen Psychiatry (1996) 2.99

The rhythm of the normal human heart. Lancet (1976) 2.94

Thiamin biosynthesis in prokaryotes. Arch Microbiol (1999) 2.91

Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects. N Engl J Med (1983) 2.91

BRCA2 mutations in primary breast and ovarian cancers. Nat Genet (1996) 2.91

Risk factors for complication following ERCP; results of a large-scale, prospective multicenter study. Endoscopy (2007) 2.88

Sensitive system for visualising biotinylated DNA probes hybridised in situ: rapid sex determination of intact cells. J Clin Pathol (1985) 2.84

The Huntington's disease candidate region exhibits many different haplotypes. Nat Genet (1992) 2.84

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci U S A (1995) 2.80

Identification of the major intestinal fatty acid transport protein. Mol Cell (1999) 2.65

Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst (1995) 2.64

Screening and optimization strategies for macromolecular crystal growth. Acta Crystallogr D Biol Crystallogr (1994) 2.62

Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab (2011) 2.59

A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity (1998) 2.56

Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Cell (1995) 2.49

Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Science (1983) 2.47

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J Biol Chem (1999) 2.45

Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum. Gut (1989) 2.44

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol (2000) 2.40

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients. Proc Natl Acad Sci U S A (1985) 2.38

Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Nat Genet (1994) 2.35

Protamine is an inhibitor of angiogenesis. Nature (1982) 2.30

Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Ann Intern Med (1997) 2.22

Experience in third molar surgery: an update. Br Dent J (2010) 2.22

Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ (2010) 2.17

Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. Stroke (1999) 2.17

Observer variation in the detection of colorectal neoplasia on double-contrast barium enema: implications for colorectal cancer screening and training. Clin Radiol (2003) 2.12

Photosynthetic Carbon Fixation in Guard Cell Protoplasts of Vicia faba L. : Evidence from Radiolabel Experiments. Plant Physiol (1988) 2.12

Twenty-four-hour intragastric pH patterns in ICU patients on ranitidine. Dig Dis Sci (1992) 2.04

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat Med (1999) 2.03

A phase II study of sorafenib in patients with chemo-naive castration-resistant prostate cancer. Ann Oncol (2007) 2.03

Fundamental training. Br Dent J (2009) 2.03

Does examination of urinary sediment identify individuals with Gulf War syndrome? A pilot study. Am J Med Sci (1998) 2.03

Airway obstruction with percutaneous tracheostomy. Chest (1997) 2.02

Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology (1997) 1.99

Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol. J Biol Chem (1988) 1.98

The effect of bupivacaine skull block on the hemodynamic response to craniotomy. Anesth Analg (1996) 1.97

Interleukin 2 receptor expression by macrophages in inflammatory bowel disease. Clin Exp Immunol (1988) 1.95

Current outcome of antenally diagnosed cystic lung disease. J Pediatr Surg (2004) 1.95

Groin hernia repair in Scotland. Br J Surg (2000) 1.93

Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens--a randomized clinical trial. Clin Infect Dis (2011) 1.92

Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element. Nature (1984) 1.92

Spread of Mycobacterium tuberculosis in a community implementing recommended elements of tuberculosis control. JAMA (2000) 1.88

Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arterioscler Thromb Vasc Biol (2001) 1.86

Infectious agents are not necessary for murine atherogenesis. J Exp Med (2000) 1.85

Health and exposures of United Kingdom Gulf war veterans. Part I: The pattern and extent of ill health. Occup Environ Med (2001) 1.84

Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain (2000) 1.83

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Phosphorylation of site 5 by glycogen synthase kinase-5 (casein kinase-II) is a prerequisite for phosphorylation of sites 3 by glycogen synthase kinase-3. FEBS Lett (1982) 1.82

The solitary thyroid nodule--benign or malignant. Praxis (1967) 1.81

Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod (1998) 1.80

Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma: A preliminary study. Cancer (1999) 1.77

Mitochondrial DNA sequence diversity in bipolar affective disorder. Am J Psychiatry (2000) 1.77

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain (2001) 1.76

National survey of stress ulcer prophylaxis. Crit Care Med (1999) 1.72

Muscular contraction: kinetics of crossbridge attachment studied by high-frequency stiffness measurements. Science (1982) 1.71

Respiratory morbidity and lung function after whooping-cough. Lancet (1983) 1.71

Group C Niemann-Pick disease: faulty regulation of low-density lipoprotein uptake and cholesterol storage in cultured fibroblasts. FASEB J (1987) 1.71

Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial function. Circulation (1992) 1.70

Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut (2008) 1.69

Role of serial plasma C.E.A. assays in detection of recurrent and metastatic colorectal carcinomas. Br Med J (1974) 1.69

In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc Natl Acad Sci U S A (2000) 1.67

Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem (2001) 1.67

Are there age and sex differences in the investigation and treatment of heart failure? A population-based study. Br J Gen Pract (2000) 1.67

hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer (2003) 1.65

Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor dutasteride. Eur Urol (2003) 1.63

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. Mol Psychiatry (2012) 1.63

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac. Mol Cell Biol (1998) 1.63

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene (2012) 1.62

Introducing care pathway commissioning to primary dental care: measuring performance. Br Dent J (2011) 1.61

Low back pain in schoolchildren: the role of mechanical and psychosocial factors. Arch Dis Child (2003) 1.61

Audit of the safety and effectiveness of ketamine for procedural sedation in the emergency department. Emerg Med J (2008) 1.60

Sperm DNA quality predicts intrauterine insemination outcome: a prospective cohort study. Hum Reprod (2002) 1.60

Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer. BMJ (2003) 1.60

Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100. J Clin Invest (1998) 1.59

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy (2011) 1.59

Epidemiological studies of tooth wear and dental erosion in 14-year-old children in North West England. Part 1: The relationship with water fluoridation and social deprivation. Br Dent J (2004) 1.59

Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member. Biochem Biophys Res Commun (2000) 1.59

Phytochromes and photomorphogenesis in Arabidopsis. Philos Trans R Soc Lond B Biol Sci (1998) 1.57

Female patients with breast carcinoma age 30 years and younger have a poor prognosis: the M.D. Anderson Cancer Center experience. Cancer (2001) 1.57

Serum müllerian-inhibiting substance levels during normal menstrual cycles. Fertil Steril (2000) 1.56

Cloning and functional expression of a human heparanase gene. Biochem Biophys Res Commun (1999) 1.56

Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet (2007) 1.55