Published in Mol Biol Cell on December 27, 2006
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions. Nature (2008) 1.98
Regulation of cell migration by dynamic microtubules. Semin Cell Dev Biol (2011) 1.64
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J Cell Biol (2010) 1.59
The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. Neuron (2009) 1.39
The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. Mol Biol Cell (2011) 1.26
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. J Cell Biol (2010) 1.21
Microtubule plus-end binding protein EB1 is necessary for muscle cell differentiation, elongation and fusion. J Cell Sci (2009) 1.17
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J (2010) 1.10
CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia (2008) 1.08
RNA localization and polarity: from A(PC) to Z(BP). Trends Cell Biol (2009) 1.07
Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion. Mol Biol Cell (2010) 1.01
The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules. J Cell Biol (2013) 1.01
Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutat Res (2009) 1.00
Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. PLoS One (2010) 0.98
APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology. BMC Cancer (2013) 0.98
Novel association of APC with intermediate filaments identified using a new versatile APC antibody. BMC Cell Biol (2009) 0.97
APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration. Mol Biol Cell (2012) 0.95
A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development (2009) 0.94
Coordination of cell polarity during Xenopus gastrulation. PLoS One (2008) 0.93
Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene (2010) 0.88
End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis. FEBS Lett (2014) 0.87
Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. Dev Biol (2010) 0.86
Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. J Biol Chem (2012) 0.85
DDA3 associates with microtubule plus ends and orchestrates microtubule dynamics and directional cell migration. Sci Rep (2013) 0.85
Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS One (2013) 0.85
Role of APC and its binding partners in regulating microtubules in mitosis. Adv Exp Med Biol (2009) 0.83
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell (2015) 0.83
Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn (2010) 0.81
Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene. Dev Neurosci (2008) 0.80
The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. J Cell Sci (2012) 0.80
Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2. Sci Rep (2016) 0.80
Lessons from development: A role for asymmetric stem cell division in cancer. Stem Cell Res (2009) 0.79
Control of cell migration through mRNA localization and local translation. Wiley Interdiscip Rev RNA (2014) 0.79
Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization. PLoS One (2013) 0.78
Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS. Development (2016) 0.78
Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines. Cancer Genet (2011) 0.76
Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells. Genom Data (2016) 0.75
Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway. Mol Biol Cell (2016) 0.75
Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover. J Cell Biol (2017) 0.75
Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration. Nat Commun (2017) 0.75
Wnt signaling and cancer. Genes Dev (2000) 18.53
HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A (2003) 5.56
Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol (2001) 4.90
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol (1996) 4.56
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat Cell Biol (2004) 4.55
A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol (2001) 4.18
Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol (2003) 4.13
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell (2004) 4.05
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol (2001) 3.13
Mutated APC and Asef are involved in the migration of colorectal tumour cells. Nat Cell Biol (2003) 2.34
Asef, a link between the tumor suppressor APC and G-protein signaling. Science (2000) 2.25
Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: implications for the role of dynamic microtubules in cell locomotion. J Cell Sci (1995) 2.20
A workingperson's guide to deconvolution in light microscopy. Biotechniques (2001) 2.15
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Cell biology: Tubulin acetylation and cell motility. Nature (2003) 2.10
Intracellular mechanics of migrating fibroblasts. Mol Biol Cell (2004) 2.06
The role of stathmin in the regulation of the cell cycle. J Cell Biochem (2004) 2.05
Identification of a link between the tumour suppressor APC and the kinesin superfamily. Nat Cell Biol (2002) 1.93
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol (2004) 1.90
Microtubules are acetylated in domains that turn over slowly. J Cell Sci (1989) 1.86
Epothilones: mechanism of action and biologic activity. J Clin Oncol (2004) 1.80
Distribution of tyrosinated and nontyrosinated alpha-tubulin during mitosis. J Cell Biol (1986) 1.59
The APC gene in colorectal cancer. Eur J Cancer (2002) 1.55
APC expression in normal human tissues. J Pathol (1997) 1.44
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol (2002) 1.43
Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell (2006) 1.42
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res (2006) 1.40
D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res (2001) 1.38
Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J Cell Sci (2005) 1.34
The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell (2004) 1.25
Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Rep (2005) 1.04
Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. Cancer Res (2005) 0.96
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell (2006) 6.02
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Differential transmission of actin motion within focal adhesions. Science (2007) 5.36
Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol (2003) 5.29
A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol Biol Cell (2004) 3.80
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol (2005) 3.20
Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol (2005) 2.89
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. Dev Cell (2007) 2.73
Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells. J Cell Biol (2002) 2.67
Quantitative fluorescent speckle microscopy of cytoskeleton dynamics. Annu Rev Biophys Biomol Struct (2006) 2.62
Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. Science (2010) 2.49
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J Cell Biol (2007) 2.31
Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy. Proc Natl Acad Sci U S A (2004) 2.25
Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells. J Cell Biol (2005) 2.24
Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility. Curr Biol (2004) 2.07
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2003) 1.99
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol (2007) 1.77
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. J Cell Sci (2007) 1.73
A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells. Methods (2003) 1.59
Converging populations of f-actin promote breakage of associated microtubules to spatially regulate microtubule turnover in migrating cells. Curr Biol (2002) 1.58
Cell regulation by the Apc protein Apc as master regulator of epithelia. Curr Opin Cell Biol (2008) 1.53
Focal loss of actin bundles causes microtubule redistribution and growth cone turning. J Cell Biol (2002) 1.47
Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network. Bioessays (2014) 1.45
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells. J Cell Biol (2002) 1.43
Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell (2006) 1.42
Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine (2004) 1.31
The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell (2004) 1.25
Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis. Biotechniques (2006) 1.17
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16
Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles. Bioorg Med Chem (2006) 1.11
Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance. J Cell Sci (2013) 1.09
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II. Mol Biol Cell (2003) 1.07
Redefining the subcellular location and transport of APC: new insights using a panel of antibodies. EMBO Rep (2005) 1.04
Dephosphorylation of the inhibitory phosphorylation site S287 in Xenopus Cdc25C by protein phosphatase-2A is inhibited by 14-3-3 binding. FEBS Lett (2002) 1.00
Novel self-association of the APC molecule affects APC clusters and cell migration. J Cell Sci (2008) 1.00
Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling. J Cell Sci (2006) 0.99
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci (2005) 0.98
Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. Cancer Res (2005) 0.96
A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath. PLoS Comput Biol (2012) 0.94
Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost. Philos Trans R Soc Lond B Biol Sci (2013) 0.90
Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP. J Cell Sci (2010) 0.88
Computational models reveal a passive mechanism for cell migration in the crypt. PLoS One (2013) 0.88
The effects of collapsing factors on F-actin content and microtubule distribution of Helisoma growth cones. Cell Motil Cytoskeleton (2005) 0.83
Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Dis Model Mech (2012) 0.83
Molecular cloning and characterization of sphingolipid ceramide N-deacylase from a marine bacterium, Shewanella alga G8. J Biol Chem (2002) 0.81
Molecular cloning and expression of Mn(2+)-dependent sphingomyelinase/hemolysin of an aquatic bacterium, Pseudomonas sp. strain TK4. J Bacteriol (2002) 0.81
The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively. J Cell Sci (2012) 0.80
The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. PLoS One (2012) 0.80
A high-resolution multimode digital microscope system. Methods Cell Biol (2007) 0.79
A high-resolution multimode digital microscope system. Methods Cell Biol (2013) 0.78
A high-resolution multimode digital microscope system. Methods Cell Biol (2003) 0.77
SPLICEFINDER - a fast and easy screening method for active protein trans-splicing positions. PLoS One (2013) 0.75