Published in Proc Natl Acad Sci U S A on August 23, 2010
Murine models of systemic lupus erythematosus. J Biomed Biotechnol (2011) 1.84
Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev Immunol (2012) 1.72
Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol (2011) 1.67
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet (2012) 1.49
Recent insights into the genetic basis of systemic lupus erythematosus. Ann Rheum Dis (2012) 1.35
Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. J Immunol (2012) 1.21
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Immunity (2015) 1.17
B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice. J Immunol (2012) 1.13
Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res (2011) 1.07
Progesterone and autoimmune disease. Autoimmun Rev (2011) 1.05
Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases. PLoS One (2014) 1.04
TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res Ther (2011) 1.02
Gender differences in the pathogenesis and outcome of lupus and of lupus nephritis. Clin Dev Immunol (2012) 0.99
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet (2013) 0.99
Dysregulation of immune homeostasis in autoimmune diseases. Nat Med (2012) 0.98
Advances in lupus genetics and epigenetics. Curr Opin Rheumatol (2014) 0.98
TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice. Proc Natl Acad Sci U S A (2014) 0.97
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study. BMC Med Genet (2012) 0.96
Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity. J Autoimmun (2012) 0.96
Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol (2014) 0.94
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells. J Exp Med (2013) 0.94
Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways. J Leukoc Biol (2012) 0.94
Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage. Curr Opin Immunol (2014) 0.92
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep (2014) 0.92
Toll-like receptors and human disease: lessons from single nucleotide polymorphisms. Curr Genomics (2012) 0.92
Advances in lupus genetics. Curr Opin Rheumatol (2015) 0.92
Abnormal production of pro- and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells. PLoS One (2011) 0.88
Sexual dimorphism in autoimmunity. J Clin Invest (2015) 0.87
Contributions of B cells to lupus pathogenesis. Mol Immunol (2013) 0.87
Translating the Untranslated Region. J Immunol (2015) 0.86
B-cell selection and the development of autoantibodies. Arthritis Res Ther (2012) 0.86
Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus. J Interferon Cytokine Res (2011) 0.86
B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production. Curr Opin Immunol (2015) 0.85
Association of systemic lupus erythematosus susceptibility genes with IgA nephropathy in a Chinese cohort. Clin J Am Soc Nephrol (2014) 0.85
Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun (2013) 0.85
Fueling autoimmunity: type I interferon in autoimmune diseases. Expert Rev Clin Immunol (2013) 0.84
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases. Immunol Rev (2016) 0.84
Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus. Dis Model Mech (2014) 0.84
Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus. PLoS One (2012) 0.83
Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus. Clin Dev Immunol (2012) 0.83
Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus. Arthritis Res Ther (2015) 0.82
Animal Models of Interferon Signature Positive Lupus. Front Immunol (2015) 0.81
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy (2015) 0.81
Genetics of SLE: functional relevance for monocytes/macrophages in disease. Clin Dev Immunol (2012) 0.81
Altered B cell signalling in autoimmunity. Nat Rev Immunol (2017) 0.80
Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease. Arthritis Res Ther (2013) 0.80
Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1. PLoS One (2012) 0.80
Variation in the androgen receptor gene exon 1 CAG repeat correlates with manifestations of autoimmunity in women with lupus. Endocr Connect (2014) 0.79
Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis. J Clin Cell Immunol (2014) 0.79
Epigenetics and autoimmune diseases: the X chromosome-nucleolus nexus. Front Genet (2015) 0.79
Spontaneous activation of RNA-sensing pathways in autoimmune disease. Curr Opin Immunol (2013) 0.78
Lupus pathobiology based on genomics. Immunogenetics (2016) 0.78
A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells. Vaccine (2015) 0.78
Genomic architecture of asthma differs by sex. Genomics (2015) 0.77
Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques. PLoS One (2011) 0.77
Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice. PLoS One (2016) 0.77
Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population. Arthritis Res Ther (2011) 0.76
Connective tissue diseases. Unravelling aetiology in male SLE--the X chromosome dose effect. Nat Rev Rheumatol (2012) 0.76
Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9. Proc Natl Acad Sci U S A (2016) 0.76
Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment. Front Pharmacol (2014) 0.76
Scavenging nucleic acid debris to combat autoimmunity and infectious disease. Proc Natl Acad Sci U S A (2016) 0.75
Polymorphisms in Toll-like receptor genes are associated with vitiligo. Front Genet (2015) 0.75
Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention. Curr Allergy Asthma Rep (2012) 0.75
Clinical perspectives on lupus genetics: advances and opportunities. Rheum Dis Clin North Am (2014) 0.75
A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without. BMC Med Genomics (2016) 0.75
A systems approach to renal inflammation in SLE. Clin Immunol (2016) 0.75
Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling. Arthritis Res Ther (2017) 0.75
Predictive value of TLR7 polymorphism for cetuximab-based chemotherapy in patients with metastatic colorectal cancer. Int J Cancer (2017) 0.75
Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection. Sci Rep (2017) 0.75
Solving the genetic puzzle of systemic lupus erythematosus. Pediatr Nephrol (2014) 0.75
Updates in Lupus Genetics. Curr Rheumatol Rep (2017) 0.75
Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity. Clin Rev Allergy Immunol (2017) 0.75
Single nucleotide polymorphisms of toll-like receptor 7 in hepatitis C virus infection patients from a high-risk chinese population. Inflammation (2015) 0.75
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum (1997) 43.47
Origins and functional impact of copy number variation in the human genome. Nature (2009) 23.63
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet (1992) 11.38
Systemic lupus erythematosus. N Engl J Med (2008) 10.22
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med (2008) 9.61
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol (2008) 6.17
Systemic lupus erythematosus disease activity index 2000. J Rheumatol (2002) 6.11
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity (2006) 6.00
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity (2006) 5.47
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science (2006) 5.30
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet (2008) 5.00
Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1. Nat Med (2009) 4.22
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity (2007) 4.07
Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing. Nat Genet (2010) 3.49
The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol (2008) 3.29
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet (2010) 2.74
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum (2006) 2.50
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol (2007) 2.32
TLR7 ligands induce higher IFN-alpha production in females. J Immunol (2006) 1.88
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum (2008) 1.64
Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients. Arthritis Res Ther (2008) 1.23
Gender differences in systemic lupus erythematosus. Gend Med (2004) 1.12
Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects. Arthritis Rheum (2007) 1.11
Quantification of allele-specific G-protein beta3 subunit mRNA transcripts in different human cells and tissues by Pyrosequencing. Eur J Hum Genet (2005) 0.99
Androgen receptor gene CAG repeat polymorphism and X-chromosome inactivation in children with premature adrenarche. J Clin Endocrinol Metab (2008) 0.83
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med (2003) 10.82
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron (2011) 10.61
Common variants conferring risk of schizophrenia. Nature (2009) 10.37
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol (2012) 7.39
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J Hum Genet (2008) 7.13
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum (2012) 6.85
American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res (Hoboken) (2012) 6.51
Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med (2005) 5.50
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet (2012) 5.11
Influenza-related hospitalizations among children in Hong Kong. N Engl J Med (2002) 4.30
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol (2011) 4.26
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet (2002) 4.03
Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study. Arthritis Rheum (2013) 4.02
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol (2007) 3.49
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum (2009) 3.44
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42
Measuring the burden of disease in Korea. J Korean Med Sci (2007) 3.37
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet (2005) 3.15
Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell (2005) 3.04
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med (2005) 2.92
Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum (2006) 2.90
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
Structural basis for Ca(2+)-induced activation of human PAD4. Nat Struct Mol Biol (2004) 2.74
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet (2010) 2.74
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. Elife (2013) 2.67
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med (2012) 2.66
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol (2010) 2.63
Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum (2008) 2.62
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60
Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis (2009) 2.60
International survey on willingness-to-pay (WTP) for one additional QALY gained: what is the threshold of cost effectiveness? Health Econ (2010) 2.57
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
A genomewide screen of 345 families for autism-susceptibility loci. Am J Hum Genet (2003) 2.51
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum (2006) 2.50
Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol (2004) 2.49
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell (2008) 2.49
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet (2009) 2.46
Biologic discontinuation studies: a systematic review of methods. Ann Rheum Dis (2013) 2.42
Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) (2010) 2.33
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2009) 2.31
Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. Am J Hum Genet (2001) 2.29
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature (2009) 2.27
Evidence for sex-specific risk alleles in autism spectrum disorder. Am J Hum Genet (2004) 2.24
Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Ann Rheum Dis (2013) 2.21
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis (2008) 2.20
Genetic susceptibility to systemic lupus erythematosus in the genomic era. Nat Rev Rheumatol (2010) 2.18
Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Proc Natl Acad Sci U S A (2004) 2.15
Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine. J Clin Rheumatol (2005) 2.14
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med (2008) 2.13
A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science (2006) 2.09
Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med (2002) 2.09
A quantitative trait locus analysis of social responsiveness in multiplex autism families. Am J Psychiatry (2007) 2.09
Effects of pharyngeal cooling on brain temperature in primates and humans: a study for proof of principle. Anesthesiology (2012) 2.08
Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression. J Rheumatol (2011) 2.08
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med (2009) 2.08
Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med (2007) 2.08
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis (2011) 2.06
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS One (2008) 1.98
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97