Published in J Mol Med (Berl) on August 24, 2010
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol (2013) 1.42
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate. J Clin Pharmacol (2011) 1.03
Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation. Blood (2014) 1.02
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxid Redox Signal (2013) 0.94
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation. Front Cell Dev Biol (2014) 0.89
Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PLoS One (2012) 0.88
Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension. Pulm Circ (2012) 0.86
Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells. J Mol Med (Berl) (2014) 0.84
Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med (2013) 0.84
Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. J Biomech (2014) 0.84
Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Am J Respir Cell Mol Biol (2013) 0.84
Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension. Pulm Circ (2011) 0.83
Mitochondrial mechanisms in cerebral vascular control: shared signaling pathways with preconditioning. J Vasc Res (2014) 0.82
DNA Damage and Pulmonary Hypertension. Int J Mol Sci (2016) 0.81
Molecular pathogenesis and current pathology of pulmonary hypertension. Heart Fail Rev (2016) 0.80
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacol Ther (2016) 0.77
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One (2016) 0.77
Redox regulation of ion channels in the pulmonary circulation. Antioxid Redox Signal (2014) 0.77
Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. JCI Insight (2017) 0.75
Inhibition of fatty acid synthase is protective in pulmonary hypertension. Br J Pharmacol (2016) 0.75
Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J (2017) 0.75
New hope for Nutlin-3a therapy for pulmonary arterial hypertension. Front Pharmacol (2013) 0.75
Novel approaches to pulmonary arterial hypertension drug discovery. Expert Opin Drug Discov (2016) 0.75
Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells. Int J Biol Sci (2017) 0.75
Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol (2016) 0.75
Novel putative pharmacologic therapies to protect the right ventricle in pulmonary hypertension: A review of current literature. Br J Pharmacol (2017) 0.75
Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res (2017) 0.75
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation (2007) 3.33
Counterpoint: release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are not the main effectors for full and sustained HPV. J Appl Physiol (1985) (2007) 2.98
Endothelin axis is upregulated in human and rat right ventricular hypertrophy. Circ Res (2012) 2.83
Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. Arch Intern Med (2004) 2.78
Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension. N Engl J Med (2009) 2.64
Hypoxic pulmonary vasoconstriction. J Appl Physiol (1985) (2005) 2.38
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest (2005) 2.32
Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation (2009) 2.17
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res (2004) 2.06
Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension. Sci Transl Med (2010) 2.04
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A (2007) 1.93
An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol (2006) 1.76
Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension. J Mol Med (Berl) (2011) 1.56
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation (2003) 1.54
Targeting cell motility in pulmonary arterial hypertension. Eur Respir J (2013) 1.47
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation (2003) 1.46
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology. Front Oncol (2013) 1.42
The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation (2006) 1.26
Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation (2006) 1.21
Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis. Circulation (2009) 1.19
A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension. J Mol Med (Berl) (2013) 1.18
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study. Am J Physiol Lung Cell Mol Physiol (2007) 1.17
CD36 expression contributes to age-induced cardiomyopathy in mice. Circulation (2007) 1.15
A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted. J Thorac Cardiovasc Surg (2008) 1.15
Role for DNA damage signaling in pulmonary arterial hypertension. Circulation (2013) 1.11
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation (2004) 1.09
Mitochondria in vascular health and disease. Annu Rev Physiol (2012) 1.08
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2006) 1.07
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension. Circulation (2012) 1.06
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. J Cancer Res Clin Oncol (2014) 1.05
The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels. FASEB J (2004) 1.01
Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus. Pediatr Res (2008) 0.95
Spatio-temporal diversity of apoptosis within the vascular wall in pulmonary arterial hypertension: heterogeneous BMP signaling may have therapeutic implications. Circ Res (2006) 0.93
O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide. Biol Chem (2004) 0.93
Pulmonary arterial hypertension: challenges in translational research and a vision for change. Sci Transl Med (2013) 0.92
A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors. Invest New Drugs (2015) 0.91
Mitochondrial medicine: a new era in medicine opens new windows and brings new challenges. Circulation (2008) 0.89
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. Am J Physiol Heart Circ Physiol (2002) 0.88
The metabolic basis of vascular oxygen sensing: diversity, compartmentalization, and lessons from cancer. Am J Physiol Heart Circ Physiol (2008) 0.84
A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system. Novartis Found Symp (2006) 0.84
Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells. J Mol Med (Berl) (2014) 0.84
The estrogen puzzle in pulmonary arterial hypertension. Circulation (2012) 0.83
Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop. Arch Biochem Biophys (2011) 0.83
Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease. Drugs Aging (2005) 0.83
A global pulmonary arterial hypertension registry: is it needed? Is it feasible? Pulmonary vascular disease: the global perspective. Chest (2010) 0.82
New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy. Curr Opin Cardiol (2010) 0.82
Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis. J Vis Exp (2012) 0.80
Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design. Eur J Heart Fail (2012) 0.80
Metabolic modulation of cancer: a new frontier with great translational potential. J Mol Med (Berl) (2015) 0.79
The chicken embryo as a model for ductus arteriosus developmental biology: cracking into new territory. Am J Physiol Regul Integr Comp Physiol (2006) 0.77
The impact of current and novel anti-diabetic therapies on cardiovascular risk. Future Cardiol (2012) 0.77
Mitochondrial NOS is upregulated in the hypoxic heart: implications for the function of the hypertrophied right ventricle. Am J Physiol Heart Circ Physiol (2009) 0.76
A redox-metabolic-electrical remodeling in the diseased left and right ventricle: direct clinical implications in heart disease and beyond. Focus on "Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts". Am J Physiol Cell Physiol (2009) 0.75
F2-isoprostanes: an emerging pulmonary arterial hypertension biomarker and potential link to the metabolic theory of pulmonary arterial hypertension? Chest (2012) 0.75
An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc (2017) 0.75