Published in Clin Pharmacol Ther on August 25, 2010
PMDA's challenge to accelerate clinical development and review of new drugs in Japan. Clin Pharmacol Ther (2010) 0.81
Potential factors correlating to the PMDA's decision to waive Japanese Phase 2 and 3 studies for oncology drugs New Drug Application in Japan. Invest New Drugs (2012) 0.75
Cultures in chimpanzees. Nature (1999) 13.33
Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature (1987) 7.23
Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol (1992) 5.93
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet (2001) 5.80
The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46
Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions. J Gen Virol (1991) 5.03
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Nature (1998) 4.06
Ancient linkage groups and frozen accidents. Nature (1973) 3.57
Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver. Biochim Biophys Acta (1989) 3.47
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med (1990) 3.05
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.86
Collective bulk carrier delocalization driven by electrostatic surface charge accumulation. Nature (2012) 2.80
Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med (1990) 2.72
Localization of pancreatic endocrine tumors by endoscopic ultrasonography. N Engl J Med (1992) 2.70
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol (1994) 2.70
Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol (1999) 2.69
Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells. J Cell Biol (1998) 2.64
Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. Proc Natl Acad Sci U S A (1995) 2.35
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics (2001) 2.29
Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. Gene (1988) 2.20
Heptakis(2,6-O-dimethyl)beta-cyclodextrin: a novel growth stimulant for Bordetella pertussis phase I. J Clin Microbiol (1983) 2.17
Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion (2001) 2.16
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells (2001) 2.13
Effect of heptakis (2,6-O-dimethyl) beta-cyclodextrin on the production of pertussis toxin by Bordetella pertussis. Infect Immun (1983) 2.06
Expression and function of the ST2 gene in a murine model of allergic airway inflammation. Clin Exp Allergy (2002) 2.02
Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med (2001) 2.02
Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem (1999) 2.00
Successful nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. Endoscopy (2006) 1.97
Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension. Cell Motil Cytoskeleton (1998) 1.96
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res (1997) 1.94
Local ordering in the pseudogap state of the high-Tc superconductor Bi2Sr2CaCu2O(8+delta). Science (2004) 1.94
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism. Proc Natl Acad Sci U S A (2003) 1.92
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun (2000) 1.91
Identification of a photoreceptor cell-specific nuclear receptor. Proc Natl Acad Sci U S A (1999) 1.88
Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell (1998) 1.86
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. J Cell Biol (2001) 1.84
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J Biol Chem (2001) 1.84
Electronic phase diagram of high-Tc cuprate superconductors from a mapping of the in-plane resistivity curvature. Phys Rev Lett (2004) 1.83
Evolution of the archaeal rhodopsins: evolution rate changes by gene duplication and functional differentiation. J Mol Biol (1999) 1.83
Efficient targeting of gene expression in chick embryos by microelectroporation. Dev Growth Differ (1999) 1.81
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev (1998) 1.76
Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf. Science (1998) 1.74
Population dynamics of Japanese monkeys with special reference to the effect of artificial feeding. Folia Primatol (Basel) (1982) 1.73
Pathology and prognosis of gastric carcinoma: well versus poorly differentiated type. Cancer (2000) 1.71
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem (1995) 1.69
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol (1999) 1.69
Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds. Nature (1999) 1.68
Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Mol Pharmacol (2001) 1.67
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. J Biol Chem (2001) 1.67
Tbx5 and the retinotectum projection. Science (2000) 1.65
Energy landscape of a peptide consisting of alpha-helix, 3(10)-helix, beta-turn, beta-hairpin, and other disordered conformations. Protein Sci (2001) 1.64
Specific histocompatibility antigens associated with Behçet's disease. Am J Ophthalmol (1975) 1.63
Jejunal interposition to prevent postgastrectomy syndromes. Br J Surg (2000) 1.62
Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique. J Nucl Med (1996) 1.62
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem (2000) 1.60
Tissue-specific expression of a cloned chick delta-crystallin gene in mouse cells. Nature (1983) 1.60
Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A (1994) 1.59
Early and late recurrence after gastrectomy for gastric carcinoma. Univariate and multivariate analyses. Cancer (2000) 1.59
Outcomes of endoscopic submucosal dissection for early gastric cancer with special reference to validation for curability criteria. Endoscopy (2009) 1.58
Phosphorylation of human fascin inhibits its actin binding and bundling activities. J Biol Chem (1996) 1.57
Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs. J Assoc Off Anal Chem (1981) 1.57
Effect of heat stress on muscle sympathetic nerve activity in humans. J Auton Nerv Syst (1997) 1.55
Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). J Agric Food Chem (2001) 1.55
[A case of colon cancer with tension pneumothorax and empyema as a consequence of colo-pleural fistula]. Nihon Kokyuki Gakkai Zasshi (2000) 1.53
In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. Eur J Biochem (2000) 1.53
Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge. J Control Release (2001) 1.52
Advantage of delayed whole-body FDG-PET imaging for tumour detection. Eur J Nucl Med (2001) 1.52
Comparisons of intraosseous graft healing between the doubled flexor tendon graft and the bone-patellar tendon-bone graft in anterior cruciate ligament reconstruction. Arthroscopy (2001) 1.51
Changes in S100beta protein levels in cerebrospinal fluid after thoracoabdominal aortic operations. J Thorac Cardiovasc Surg (2001) 1.51
Mycobacterium avium complex disease: prognostic implication of high-resolution computed tomography findings. Eur Respir J (2008) 1.49
[Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis]. Nihon Kyobu Shikkan Gakkai Zasshi (1987) 1.48
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem (1999) 1.48
On-chip culture system for observation of isolated individual cells. Lab Chip (2001) 1.47
Cytosol androgen receptor from kidney of normal and testicular feminized (Tfm) mice. Cell (1974) 1.47
Overt congestive heart failure with mitral and aortic regurgitation due to antiphospholipid syndrome in a patient with systemic lupus erythematosus. Intern Med (2000) 1.46
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest (1997) 1.45
N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K). Clin Pharmacol Ther (2012) 1.45
Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol (1985) (2001) 1.44
Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects. Am J Physiol (1998) 1.44
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem Biophys Res Commun (2000) 1.43
Analysis of single-cell differences by use of an on-chip microculture system and optical trapping. Fresenius J Anal Chem (2001) 1.41
Emergence of the precore mutant late in chronic hepatitis B infection correlates with the severity of liver injury and mutations in the core region. Am J Gastroenterol (2000) 1.41
Cerebral blood flow measurement with iodine-123-IMP SPECT, calibrated standard input function and venous blood sampling. J Nucl Med (1995) 1.41
1H-NMR analysis of nerve edema in the streptozotocin-induced diabetic rat. J Lab Clin Med (1994) 1.40
Concomitant abdominal aortic aneurysm repair and cholecystectomy. Combination of retroperitoneal aortic reconstruction and gassless laparoscopic cholecystectomy. J Cardiovasc Surg (Torino) (2000) 1.39
Hazard of glucagon test in diabetic patients. Hypertensive crisis in asymptomatic pheochromocytoma. Diabetes Care (1992) 1.39
Early-stage laryngeal squamous cell carcinoma of the epiglottis treated by endoscopic submucosal dissection. Endoscopy (2008) 1.39
Intrinsic tunneling spectra of Bi2(Sr(2-x)Lax)CuO(6+delta). Phys Rev Lett (2003) 1.39
Ex vivo pilot study using computed analysis of endo-cytoscopic images to differentiate normal and malignant squamous cell epithelia in the oesophagus. Dig Liver Dis (2007) 1.39
A new familial adult-onset leukodystrophy manifesting as cerebellar ataxia and dementia. J Neurol Sci (2001) 1.39
Food intake and platelet aggregability. Lancet (1992) 1.39
Solid cell nests of the thyroid gland: precursor of mucoepidermoid carcinoma? World J Surg (1992) 1.38
Leukemia inhibitory factor induces epidermal hyperplasia in patients with amyotrophic lateral sclerosis. J Invest Dermatol (2000) 1.38
Functional anatomy of GO/NO-GO discrimination and response selection--a PET study in man. Brain Res (1996) 1.38
Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor. Virology (1997) 1.36
Persistent viremia after recovery from self-limited acute hepatitis B. Hepatology (1998) 1.36
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci U S A (2000) 1.36
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem (2000) 1.34