Published in Nature on August 03, 1973
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
Extensive duplication and reshuffling in the Arabidopsis genome. Plant Cell (2000) 6.16
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution. Proc Natl Acad Sci U S A (2003) 4.54
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution. Genetics (2005) 3.98
Two types of molecular evolution. Evidence from studies of interspecific hybridization. Proc Natl Acad Sci U S A (1974) 3.69
Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase. Proc Natl Acad Sci U S A (1983) 3.33
Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res (2007) 3.11
Reconstructing the genomic architecture of ancestral mammals: lessons from human, mouse, and rat genomes. Genome Res (2004) 2.94
On the origin of new genes in Drosophila. Genome Res (2008) 2.69
How malleable is the eukaryotic genome? Extreme rate of chromosomal rearrangement in the genus Drosophila. Genome Res (2001) 2.48
An ordered comparative map of the cattle and human genomes. Genome Res (2000) 2.38
The X chromosome shows less genetic variation at restriction sites than the autosomes. Am J Hum Genet (1986) 2.22
Centromere emergence in evolution. Genome Res (2001) 2.18
Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Genetics (2008) 2.09
The fragile breakage versus random breakage models of chromosome evolution. PLoS Comput Biol (2006) 1.90
Breakpoint regions and homologous synteny blocks in chromosomes have different evolutionary histories. Genome Res (2009) 1.66
Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping. Genome Res (1999) 1.64
Comparative gene mapping: order of loci on the X chromosome is different in mice and humans. Proc Natl Acad Sci U S A (1980) 1.52
mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol Cell Biol (1992) 1.49
Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p. Proc Natl Acad Sci U S A (1978) 1.48
Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse. Proc Natl Acad Sci U S A (1981) 1.48
Gene duplication and the origin of novel proteins. Proc Natl Acad Sci U S A (2005) 1.47
Genetic mapping in a natural population of collared flycatchers (Ficedula albicollis): conserved synteny but gene order rearrangements on the avian Z chromosome. Genetics (2006) 1.41
Slow evolutionary loss of the potential for interspecific hybridization in birds: a manifestation of slow regulatory evolution. Proc Natl Acad Sci U S A (1975) 1.39
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates. Proc Natl Acad Sci U S A (2002) 1.36
Adaptive diversification within a large family of recently duplicated, placentally expressed genes. Proc Natl Acad Sci U S A (2000) 1.32
Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes. Proc Natl Acad Sci U S A (1986) 1.30
CYNTENATOR: progressive gene order alignment of 17 vertebrate genomes. PLoS One (2010) 1.28
Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics (2006) 1.27
The zeste-white interaction: induction and genetic analysis of a novel class of zeste alleles. EMBO J (1984) 1.25
Chromosome rearrangements in evolution: From gene order to genome sequence and back. Proc Natl Acad Sci U S A (2003) 1.24
Duplicate gene evolution and expression in the wake of vertebrate allopolyploidization. BMC Evol Biol (2008) 1.22
X-linked hypohidrotic ectodermal dysplasia: localization within the region Xq11-21.1 by linkage analysis and implications for carrier detection and prenatal diagnosis. Am J Hum Genet (1988) 1.21
Three rounds (1R/2R/3R) of genome duplications and the evolution of the glycolytic pathway in vertebrates. BMC Biol (2006) 1.16
Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates. Proc Natl Acad Sci U S A (1982) 1.13
Multiple mechanisms promote the retained expression of gene duplicates in the tetraploid frog Xenopus laevis. PLoS Genet (2006) 1.11
Fragile regions and not functional constraints predominate in shaping gene organization in the genus Drosophila. Genome Res (2010) 1.08
What happens to genes in duplicated genomes. Proc Natl Acad Sci U S A (2003) 1.08
Relationship, evolutionary fate and function of two maize co-orthologs of rice GW2 associated with kernel size and weight. BMC Plant Biol (2010) 1.07
Genomic rearrangements and the evolution of clusters of locally adaptive loci. Proc Natl Acad Sci U S A (2013) 1.06
High-resolution comparative mapping among man, cattle and mouse suggests a role for repeat sequences in mammalian genome evolution. BMC Genomics (2006) 1.03
Gene expression and feeding ecology: evolution of piscivory in the venomous gastropod genus Conus. Proc Biol Sci (2004) 1.00
Desulfurization of cysteine-containing peptides resulting from sample preparation for protein characterization by mass spectrometry. Rapid Commun Mass Spectrom (2010) 1.00
ZOO-FISH analysis in a species of the order Chiroptera: Glossophaga soricina (Phyllostomidae). Chromosome Res (1999) 1.00
Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice. Proc Natl Acad Sci U S A (1987) 0.99
A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL. Nucleic Acids Res (2009) 0.99
Sex chromosome evolution in moths and butterflies. Chromosome Res (2012) 0.96
The random versus fragile breakage models of chromosome evolution: a matter of resolution. Mol Genet Genomics (2007) 0.96
Evolution of caprine and ovine beta-defensin genes. Immunogenetics (2005) 0.94
Emergence of Xin demarcates a key innovation in heart evolution. PLoS One (2008) 0.94
Regulatory divergence of the duplicated chromosomal loci sox11a/b by subpartitioning and sequence evolution of enhancers in zebrafish. Mol Genet Genomics (2009) 0.93
Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency. Am J Hum Genet (1984) 0.91
Evolution of genome organizations of squirrels (Sciuridae) revealed by cross-species chromosome painting. Chromosome Res (2004) 0.90
Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes. Chromosome Res (2011) 0.89
Genomic and population-level effects of gene conversion in caenorhabditis paralogs. Genes (Basel) (2010) 0.88
Causes, effects, and constraints in the genetics of human longevity. Am J Hum Genet (1998) 0.88
A domestic cat X chromosome linkage map and the sex-linked orange locus: mapping of orange, multiple origins and epistasis over nonagouti. Genetics (2009) 0.88
Divergent patterns of breakpoint reuse in Muroid rodents. Mamm Genome (2009) 0.85
Are we degenerate tetraploids? More genomes, new facts. Biol Direct (2008) 0.84
Pufferfish and new paradigm for comparative genome analysis. Proc Natl Acad Sci U S A (1996) 0.84
Analysis of segmental duplications reveals a distinct pattern of continuation-of-synteny between human and mouse genomes. Hum Genet (2006) 0.84
Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison. J Mol Evol (2006) 0.81
FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Mol Genet Genomics (2004) 0.81
Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12. Mol Cell Biol (1984) 0.80
Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates. J Mol Evol (2006) 0.80
Defining the function of a prolactin gene family member. Proc Natl Acad Sci U S A (2004) 0.79
Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications. Dev Genes Evol (2015) 0.78
Estimation of the extent of synteny between Tetraodon nigroviridis and Homo sapiens genomes. J Mol Evol (2004) 0.77
Phylogenetic analysis of genome rearrangements among five mammalian orders. Mol Phylogenet Evol (2012) 0.77
Testing chromosomal phylogenies and inversion breakpoint reuse in Drosophila. The martensis cluster revisited. Chromosome Res (2011) 0.76
Lineage-specific loss of FGF17 within the avian orders Galliformes and Passeriformes. Gene (2015) 0.76
The human genome through the eyes of Mercator and Vesalius. Trans Am Clin Climatol Assoc (1981) 0.75
Acceleration of X-chromosome gene order evolution in the cattle lineage. BMB Rep (2013) 0.75
Recurrence of Chromosome Rearrangements and Reuse of DNA Breakpoints in the Evolution of the Triticeae Genomes. G3 (Bethesda) (2016) 0.75
Significance of positive selection and gene duplication in adaptive evolution: in memory of Austin L. Hughes. Immunogenetics (2016) 0.75
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med (1990) 3.05
Collective bulk carrier delocalization driven by electrostatic surface charge accumulation. Nature (2012) 2.80
Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol (1999) 2.69
Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells. J Cell Biol (1998) 2.64
Heptakis(2,6-O-dimethyl)beta-cyclodextrin: a novel growth stimulant for Bordetella pertussis phase I. J Clin Microbiol (1983) 2.17
Effect of heptakis (2,6-O-dimethyl) beta-cyclodextrin on the production of pertussis toxin by Bordetella pertussis. Infect Immun (1983) 2.06
Successful nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. Endoscopy (2006) 1.97
Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension. Cell Motil Cytoskeleton (1998) 1.96
Local ordering in the pseudogap state of the high-Tc superconductor Bi2Sr2CaCu2O(8+delta). Science (2004) 1.94
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res (1997) 1.94
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism. Proc Natl Acad Sci U S A (2003) 1.92
Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell (1998) 1.86
Electronic phase diagram of high-Tc cuprate superconductors from a mapping of the in-plane resistivity curvature. Phys Rev Lett (2004) 1.83
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol (1999) 1.69
Energy landscape of a peptide consisting of alpha-helix, 3(10)-helix, beta-turn, beta-hairpin, and other disordered conformations. Protein Sci (2001) 1.64
Specific histocompatibility antigens associated with Behçet's disease. Am J Ophthalmol (1975) 1.63
Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique. J Nucl Med (1996) 1.62
Molecular and physiological alterations in murine ventricular dysfunction. Proc Natl Acad Sci U S A (1994) 1.59
Outcomes of endoscopic submucosal dissection for early gastric cancer with special reference to validation for curability criteria. Endoscopy (2009) 1.58
Phosphorylation of human fascin inhibits its actin binding and bundling activities. J Biol Chem (1996) 1.57
Clinical development and review times for new drugs in Japan: associated factors. Clin Pharmacol Ther (2010) 1.54
Advantage of delayed whole-body FDG-PET imaging for tumour detection. Eur J Nucl Med (2001) 1.52
Cytosol androgen receptor from kidney of normal and testicular feminized (Tfm) mice. Cell (1974) 1.47
Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. J Appl Physiol (1985) (2001) 1.44
Cerebral blood flow measurement with iodine-123-IMP SPECT, calibrated standard input function and venous blood sampling. J Nucl Med (1995) 1.41
Ex vivo pilot study using computed analysis of endo-cytoscopic images to differentiate normal and malignant squamous cell epithelia in the oesophagus. Dig Liver Dis (2007) 1.39
Early-stage laryngeal squamous cell carcinoma of the epiglottis treated by endoscopic submucosal dissection. Endoscopy (2008) 1.39
A new familial adult-onset leukodystrophy manifesting as cerebellar ataxia and dementia. J Neurol Sci (2001) 1.39
Intrinsic tunneling spectra of Bi2(Sr(2-x)Lax)CuO(6+delta). Phys Rev Lett (2003) 1.39
Leukemia inhibitory factor induces epidermal hyperplasia in patients with amyotrophic lateral sclerosis. J Invest Dermatol (2000) 1.38
Functional anatomy of GO/NO-GO discrimination and response selection--a PET study in man. Brain Res (1996) 1.38
Delays in new drug applications in Japan and industrial R&D strategies. Clin Pharmacol Ther (2009) 1.30
Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens. J Exp Med (1986) 1.29
Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms. Endoscopy (2010) 1.28
A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor. Mol Endocrinol (1991) 1.27
Factors of biliary carcinogenesis in choledochal cysts. Eur J Pediatr Surg (2001) 1.24
Endoscopic submucosal dissection for rectal epithelial neoplasia. Endoscopy (2006) 1.22
Emergent endovascular treatment of ruptured vertebral artery dissecting aneurysms. Neuroradiology (2005) 1.18
Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian. Tissue Antigens (1997) 1.14
Evolution of the Hall coefficient and the peculiar electronic structure of the cuprate superconductors. Phys Rev Lett (2004) 1.14
Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. J Exp Med (1994) 1.14
Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock (2001) 1.14
JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res (2000) 1.11
A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice. Cancer Res (2001) 1.11
Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4. J Leukoc Biol (1997) 1.11
Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. Int Immunol (2000) 1.10
Intrapancreatic accessory spleen: diagnosis using contrast enhanced ultrasound. Br J Radiol (2004) 1.10
Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. J Exp Med (1995) 1.09
Functional anatomy of taste perception in the human brain studied with positron emission tomography. Brain Res (1994) 1.09
Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. Int J Cancer (2000) 1.08
Rapid processing of retinal slip during saccades in macaque area MT. J Neurophysiol (2005) 1.07
Enhanced motion sensitivity follows saccadic suppression in the superior temporal sulcus of the macaque cortex. Cereb Cortex (2006) 1.05
Choledochal cyst associated with duodenal atresia: case report and review of the literature. Pediatr Surg Int (2009) 1.05
Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imaging. Ann Neurol (1990) 1.03
Possible role for H--Y antigen in the primary determination of sex. Nature (1975) 1.03
Role of liver NK cells and peritoneal macrophages in gamma interferon and interleukin-10 production in experimental bacterial peritonitis in mice. Infect Immun (1998) 1.01
ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. Oncogene (2007) 1.01
Comparing acceleration and speed tuning in macaque MT: physiology and modeling. J Neurophysiol (2005) 1.00
Myopathology of hypothyroid myopathy. Some new observations. J Neurol Sci (1987) 1.00
Regional cerebral blood flow in diabetic patients: evaluation by N-isopropyl-123I-IMP with SPECT. Nucl Med Commun (1994) 1.00
Genetic implication of karyological instability of malignant somatic cells. Physiol Rev (1971) 1.00
Information processing by parafoveal cells in the primate nucleus of the optic tract. Exp Brain Res (2001) 1.00
Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. J Pharm Sci (1999) 1.00
A role for CD9 molecules in T cell activation. J Exp Med (1996) 1.00
Signal analysis and compression performance evaluation of pathological microscopic images. IEEE Trans Med Imaging (1997) 0.99
Simplicity of mammalian regulatory systems inferred by single gene determination of sex phenotypes. Nature (1971) 0.98
Neural and non-neural mediation of propionate-induced contractile responses in the rat distal colon. Neurogastroenterol Motil (2005) 0.98
Correlation between human personality and neural activity in cerebral cortex. Neuroimage (2000) 0.98
Speech intelligibility following maxillectomy with and without a prosthesis: an analysis of 54 cases. J Oral Rehabil (1998) 0.98
Activation of monocytes and endothelial cells depends on the severity of surgical stress. World J Surg (2000) 0.97
Subsite affinities of glucoamylase: examination of the validity of the subsite theory. Biochim Biophys Acta (1973) 0.97
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions. J Immunol (1997) 0.97
Phosphoglucomutase polymorphis in the rainbow trout, Salmo gairdneri. Experientia (1969) 0.97
[The effects of unilateral pulmonary artery occlusion on pulmonary extravascular water volume and broncho-alveolar lavage under unilateral pulmonary artery occlusion]. Nihon Kyobu Shikkan Gakkai Zasshi (1988) 0.96
Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters. Biochem Pharmacol (2000) 0.95
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Cell Motil Cytoskeleton (2006) 0.95
Identification of two distinct factors, B151-TRF1 and B151-TRF2, inducing differentiation of activated B cells and small resting B cells into antibody-producing cells. J Immunol (1986) 0.95
Propeller flaps: classification and clinical applications. Ann Chir Plast Esthet (2011) 0.95
Effectiveness of tranilast on restenosis after directional coronary atherectomy. Am Heart J (1997) 0.95
Abrupt transition in quasiparticle dynamics at optimal doping in a cuprate superconductor system. Phys Rev Lett (2005) 0.95
Functional heterogeneity of the Lyb-5- B cell subpopulation: mutant xid B cells and normal Lyb-5- B cells differ in their responsiveness to phenol-extracted lipopolysaccharide. J Immunol (1983) 0.95
TfM mutation and masculinization versus feminization of the mouse central nervous system. Cell (1974) 0.94
Regulation of B-cell differentiation: interactions of factors and corresponding receptors. Annu Rev Immunol (1986) 0.94
Gate control of electronic phases in a quarter-filled manganite. Sci Rep (2013) 0.94
Construction of an enantiomerically pure 6-substituted 3,5-syn-dihydroxyhexanoic acid system by an enantioselective deprotonation strategy: formal synthesis of an antiobesity agent, (-)-tetrahydrolipstatin. Chem Pharm Bull (Tokyo) (2000) 0.93
Analysis of hepatofugal flow in portal venous system using ultrasonic Doppler duplex system. Am J Gastroenterol (1989) 0.93
Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipation. Eur J Pediatr Surg (2007) 0.93
IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells. J Clin Immunol (2001) 0.93
Non-surgical correction of a congenital lop ear deformity by splinting with Reston foam. Br J Plast Surg (1982) 0.93
A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice. J Immunol (1997) 0.93
Myocardial hypertrophy in the ischemic zone induced by exercise in rats after coronary reperfusion. Circulation (1993) 0.92
Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration. Nucl Med Commun (1999) 0.92
Influence of molecular structures of substrates and analogues on Taka-amylase A catalyzed hydrolyses. I. Effect of chain length of linear substrates. J Biochem (1971) 0.92
The syngeneic mixed leukocyte reaction in mice. II. The I region control of suppressor T cell activity induced in the syngeneic mixed leukocyte reaction. J Immunol (1982) 0.92
Transforming growth factor-beta (TGF-beta)-mediated immunosuppression in the tumor-bearing state: enhanced production of TGF-beta and a progressive increase in TGF-beta susceptibility of anti-tumor CD4+ T cell function. Jpn J Cancer Res (1993) 0.92
[Analysis of contributing factors with high renal uptake of 99mTc-MDP after anti-cancer chemotherapy including cisplatin]. Kaku Igaku (1996) 0.92
Involvement of L-type-like amino acid transporters in S-nitrosocysteine-stimulated noradrenaline release in the rat hippocampus. J Neurochem (1997) 0.92
Oral manifestations and differential diagnosis of isolated hypoglossal nerve palsy: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (1997) 0.91