Published in PLoS One on August 18, 2010
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Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. Cell Signal (2006) 1.11
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Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology (2003) 1.03
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Selection of the alternative exon 1 from the cd5 gene down-regulates membrane level of the protein in B lymphocytes. J Immunol (2008) 0.91
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Identification and characterization of the human cell adhesion molecule contactin. Brain Res Mol Brain Res (1994) 0.88
Increased plasma apoM levels in the patients suffered from hepatocellular carcinoma and other chronic liver diseases. Lipids Health Dis (2008) 0.87
Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochim Biophys Acta (2007) 0.87
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Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes. Drug Metab Pharmacokinet (2007) 0.83
Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas. Oncogene (2004) 0.78
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Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
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Phylogenetic shadowing of primate sequences to find functional regions of the human genome. Science (2003) 9.93
Scanning human gene deserts for long-range enhancers. Science (2003) 9.75
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res (2002) 7.33
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The genome of the Western clawed frog Xenopus tropicalis. Science (2010) 4.70
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Regulatory potential scores from genome-wide three-way alignments of human, mouse, and rat. Genome Res (2004) 3.53
Predicting tissue-specific enhancers in the human genome. Genome Res (2007) 2.72
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CREME: a framework for identifying cis-regulatory modules in human-mouse conserved segments. Bioinformatics (2003) 2.42
A high-resolution enhancer atlas of the developing telencephalon. Cell (2013) 2.34
The DNA sequence and biology of human chromosome 19. Nature (2004) 2.29
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature (2005) 2.27
Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers. Genome Res (2010) 2.12
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Genome-wide discovery of human heart enhancers. Genome Res (2010) 1.85
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res (2002) 1.80
PhenCode: connecting ENCODE data with mutations and phenotype. Hum Mutat (2007) 1.75
Transposable elements as a significant source of transcription regulating signals. Gene (2006) 1.58
ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes. Bioinformatics (2006) 1.58
Identification of clustered YY1 binding sites in imprinting control regions. Genome Res (2006) 1.51
Variable locus length in the human genome leads to ascertainment bias in functional inference for non-coding elements. Bioinformatics (2009) 1.49
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Genomic features defining exonic variants that modulate splicing. Genome Biol (2010) 1.46
DiRE: identifying distant regulatory elements of co-expressed genes. Nucleic Acids Res (2008) 1.42
Human-zebrafish non-coding conserved elements act in vivo to regulate transcription. Nucleic Acids Res (2005) 1.39
Comparative analysis of chicken chromosome 28 provides new clues to the evolutionary fragility of gene-rich vertebrate regions. Genome Res (2007) 1.36
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. Proc Natl Acad Sci U S A (2013) 1.35
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins. Genomics (2003) 1.29
Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol (2005) 1.27
Detection and characterization of silencers and enhancer-blockers in the greater CFTR locus. Genome Res (2008) 1.21
A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. PLoS Genet (2012) 1.10
Comparative analyses of bidirectional promoters in vertebrates. BMC Bioinformatics (2008) 1.10
Genome-wide identification of conserved regulatory function in diverged sequences. Genome Res (2011) 1.07
Effects of HMGN variants on the cellular transcription profile. Nucleic Acids Res (2011) 1.05
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Global gene expression analysis of murine limb development. PLoS One (2011) 1.01
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. J Biol Chem (2013) 0.95
Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network. Proc Natl Acad Sci U S A (2012) 0.92
Cross-species mapping of bidirectional promoters enables prediction of unannotated 5' UTRs and identification of species-specific transcripts. BMC Genomics (2009) 0.91
Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. Nucleic Acids Res (2013) 0.89
Mulan: multiple-sequence alignment to predict functional elements in genomic sequences. Methods Mol Biol (2007) 0.88
Bidirectional promoters as important drivers for the emergence of species-specific transcripts. PLoS One (2013) 0.88
Differential analysis of ovarian and endometrial cancers identifies a methylator phenotype. PLoS One (2012) 0.88
Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification. Development (2014) 0.88
Spliceosomal small nuclear RNA genes in 11 insect genomes. RNA (2006) 0.88
Orthology-driven mapping of bidirectional promoters in human and mouse genomes. BMC Bioinformatics (2014) 0.87
Multi-species sequence comparison reveals dynamic evolution of the elastin gene that has involved purifying selection and lineage-specific insertions/deletions. BMC Genomics (2004) 0.86
Functional analysis of synonymous substitutions predicted to affect splicing of the CFTR gene. J Cyst Fibros (2012) 0.85
Transposable elements and their identification. Methods Mol Biol (2012) 0.85
Word-based characterization of promoters involved in human DNA repair pathways. BMC Genomics (2009) 0.84
Array2BIO: from microarray expression data to functional annotation of co-regulated genes. BMC Bioinformatics (2006) 0.83
Predicting tissue specific cis-regulatory modules in the human genome using pairs of co-occurring motifs. BMC Bioinformatics (2012) 0.83
Effects of gene regulatory reprogramming on gene expression in human and mouse developing hearts. Philos Trans R Soc Lond B Biol Sci (2013) 0.82
Systematic elucidation and in vivo validation of sequences enriched in hindbrain transcriptional control. Genome Res (2012) 0.81
Human variation in short regions predisposed to deep evolutionary conservation. Mol Biol Evol (2010) 0.81
Sequence signatures extracted from proximal promoters can be used to predict distal enhancers. Genome Biol (2013) 0.80
Genome-wide detection of a TFIID localization element from an initial human disease mutation. Nucleic Acids Res (2010) 0.79
WordSeeker: concurrent bioinformatics software for discovering genome-wide patterns and word-based genomic signatures. BMC Bioinformatics (2010) 0.77
CLARE: Cracking the LAnguage of Regulatory Elements. Bioinformatics (2011) 0.77
Using an ensemble of statistical metrics to quantify large sets of plant transcription factor binding sites. Plant Methods (2013) 0.76
Genome-wide analysis of functional and evolutionary features of tele-enhancers. G3 (Bethesda) (2014) 0.76
Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol (2010) 0.76
Finding Occurrences of Relevant Functional Elements in Genomic Signatures. Int J Comput Sci (2008) 0.76
Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics. PLoS One (2013) 0.75
Unique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephaly. PLoS One (2012) 0.75
Discovering Gene Regulatory Elements Using Coverage-based Heuristics. IEEE/ACM Trans Comput Biol Bioinform (2015) 0.75