Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 2965035)

Published in Brain Res on August 31, 2010

Authors

Emily R Rosario1, Jenna Carroll, Christian J Pike

Author Affiliations

1: Neuroscience Graduate Program, Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.

Articles citing this

Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav (2012) 1.14

Sex hormones, aging, and Alzheimer's disease. Front Biosci (Elite Ed) (2012) 1.06

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci (2013) 1.02

Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging (2012) 0.85

The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging (2015) 0.83

Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiol Dis (2011) 0.82

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem Neurosci (2013) 0.82

Efficacy of music therapy in treatment for the patients with Alzheimer's disease. Int J Alzheimers Dis (2012) 0.81

Sex steroid levels and AD-like pathology in 3xTgAD mice. J Neuroendocrinol (2013) 0.81

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein. Cell Mol Life Sci (2015) 0.78

Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition? Biol Sex Differ (2012) 0.77

Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons. Biomed Res Int (2014) 0.77

Sex and the development of Alzheimer's disease. J Neurosci Res (2017) 0.76

Hypothalamic-pituitary-gonadal axis involvement in learning and memory and Alzheimer's disease: more than "just" estrogen. Front Endocrinol (Lausanne) (2015) 0.76

Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice. Neural Regen Res (2017) 0.76

Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors. Front Neuroendocrinol (2016) 0.75

Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology (2014) 0.75

Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats. Mol Cell Endocrinol (2016) 0.75

The role of lysosomal proteinases and estradiol in neurodegeneration induced by beta-amyloid. Dokl Biochem Biophys (2015) 0.75

Articles cited by this

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron (2003) 14.03

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA (1989) 8.36

The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand (1987) 6.19

Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2006) 5.58

Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol (1997) 5.43

Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci (1997) 4.57

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging (2003) 3.83

Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol (1990) 3.80

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci (1992) 3.56

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci (2005) 3.18

The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev (2005) 3.11

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects. Pharmacol Rev (2000) 2.94

Age-related testosterone depletion and the development of Alzheimer disease. JAMA (2004) 2.45

Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism. J Neurosci (1994) 2.33

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem (2006) 2.33

A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci U S A (2001) 2.12

Sexual differentiation of the vertebrate brain: principles and mechanisms. Front Neuroendocrinol (1998) 2.01

Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci (2007) 2.00

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A (2002) 1.82

Chemical andropause and amyloid-beta peptide. JAMA (2001) 1.75

Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol (2009) 1.71

The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus. J Neurosci (2006) 1.67

Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J Neurosci (2003) 1.65

Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia. J Alzheimers Dis (2003) 1.52

An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol. Horm Behav (2007) 1.43

Cell death and sexual differentiation of the nervous system. Neuroscience (2005) 1.39

Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. J Neurosci (2008) 1.31

Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease. J Neurochem (1999) 1.30

Androgen cell signaling pathways involved in neuroprotective actions. Horm Behav (2007) 1.28

Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology (2005) 1.28

Androgens increase spine synapse density in the CA1 hippocampal subfield of ovariectomized female rats. J Neurosci (2004) 1.27

Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study. Brain Res (2005) 1.26

Epidemiology of clinically diagnosed Alzheimer's disease. Ann Neurol (1986) 1.24

The androgen metabolite, 5alpha-androstane-3beta, 17beta-diol, is a potent modulator of estrogen receptor-beta1-mediated gene transcription in neuronal cells. Endocrinology (2004) 1.22

Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology (2008) 1.22

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci (2006) 1.21

Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol (2007) 1.21

The role of androgens in cognition and brain aging in men. Neuroscience (2005) 1.19

Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus. Behav Neurosci (2004) 1.18

Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. Brain Res (2001) 1.16

Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus. Endocrinology (1995) 1.15

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging (2009) 1.14

Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Exp Neurol (2003) 1.14

Order of magnitude differences between methods for maintaining physiological 17beta-oestradiol concentrations in ovariectomized rats. Scand J Clin Lab Invest (2008) 1.12

Androgens modulate beta-amyloid levels in male rat brain. J Neurochem (2003) 1.12

Androgens modulate neuronal vulnerability to kainate lesion. Neuroscience (2003) 1.11

Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A (2000) 1.10

Thinking with your gonads: testosterone and cognition. Trends Cogn Sci (2006) 1.07

A role for the androgen metabolite, 5alpha-androstane-3beta,17beta-diol, in modulating oestrogen receptor beta-mediated regulation of hormonal stress reactivity. J Neuroendocrinol (2009) 1.06

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol Aging (2010) 1.04

Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: a systematic analysis. J Cereb Blood Flow Metab (2009) 1.04

Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. Learn Mem (2009) 1.01

5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology (2004) 1.01

Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report. J Androl (2003) 0.99

Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease. Ann N Y Acad Sci (2005) 0.99

Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem (2008) 0.97

An association of elevated serum gonadotropin concentrations and Alzheimer disease? J Neuroendocrinol (2000) 0.97

Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab (2006) 0.96

Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Res Rev (2007) 0.96

Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging. Neurobiol Aging (2002) 0.95

AR, apoE, and cognitive function. Horm Behav (2008) 0.92

The gonadotropin connection in Alzheimer's disease. Endocrine (2005) 0.91

Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 0.88

Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci Lett (2000) 0.85

Androgen and estrogen receptors in brain cytosol from male, female, and testicular feminized (tfm/y hermaphrodite) mice. Endocrinology (1976) 0.84

The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease. Proc Natl Acad Sci U S A (1997) 0.83

Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem Res (2008) 0.83

Effects of testosterone on cognitive and brain aging in elderly men. Ann N Y Acad Sci (2005) 0.82

Progression model of prostate cancer. Methods Mol Biol (2003) 0.80

Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels. J Alzheimers Dis (2008) 0.79

The controversy over levels of sex steroids in cases with Alzheimer's disease. J Neuroendocrinol (2004) 0.78

Proliferative response of seminal vesicle cells to androgen and estrogen in neonatally castrated mice. J Steroid Biochem (1986) 0.77

Receptor binding and biological effects of three 125I-iodinated estrogen derivatives in human breast cancer cells (MCF-7). J Steroid Biochem Mol Biol (1993) 0.76

Articles by these authors

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (2012) 6.66

Age-related testosterone depletion and the development of Alzheimer disease. JAMA (2004) 2.45

Progesterone receptors: form and function in brain. Front Neuroendocrinol (2008) 2.15

Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci (2007) 2.00

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci (2010) 1.60

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci (2012) 1.60

Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology (2008) 1.22

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci (2006) 1.21

Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. J Neurochem (2005) 1.20

Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci (2005) 1.20

Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol Clin Exp Res (2006) 1.18

Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology (2010) 1.18

Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Res (2006) 1.17

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging (2009) 1.14

Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav (2012) 1.14

Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res (2010) 1.08

Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. J Neurosci (2007) 1.06

Sex hormones, aging, and Alzheimer's disease. Front Biosci (Elite Ed) (2012) 1.06

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci (2013) 1.02

Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem (2003) 1.02

Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Res (2005) 1.01

Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology (2007) 0.99

Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem (2008) 0.97

Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Res Rev (2007) 0.96

Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats. Neurosci Lett (2008) 0.91

Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. J Neurochem (2005) 0.89

Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions. Curr Diab Rep (2014) 0.86

Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One (2012) 0.85

17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology (2012) 0.85

Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging (2012) 0.85

Caspase activation contributes to astrogliosis. Brain Res (2012) 0.84

Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PLoS One (2013) 0.84

Age-related changes in serum and brain levels of androgens in male Brown Norway rats. Neuroreport (2009) 0.83

Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons. Brain Res (2009) 0.83

Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res (2003) 0.80

Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice. Brain Res (2012) 0.78

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis (2005) 0.77

Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. Endocrinology (2014) 0.76

Deconvolution of the confounding variations for reverse transcription quantitative real-time polymerase chain reaction by separate analysis of biological replicate data. Anal Biochem (2012) 0.76

Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology (2014) 0.75