Published in Amino Acids on September 08, 2010
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74
A little sugar goes a long way: the cell biology of O-GlcNAc. J Cell Biol (2015) 1.48
O-GlcNAc and the epigenetic regulation of gene expression. J Biol Chem (2014) 1.27
Cracking the O-GlcNAc code in metabolism. Trends Endocrinol Metab (2013) 1.21
Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol (2011) 1.14
Altering O-linked β-N-acetylglucosamine cycling disrupts mitochondrial function. J Biol Chem (2014) 1.04
Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis. Cell Stress Chaperones (2013) 0.98
The making of a sweet modification: structure and function of O-GlcNAc transferase. J Biol Chem (2014) 0.96
O-GlcNAcylation: The Sweet Side of the Cancer. Front Oncol (2014) 0.86
O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity. Amino Acids (2014) 0.83
O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function. J Biol Chem (2015) 0.82
O-GlcNAc cycling shows neuroprotective potential in C. elegans models of neurodegenerative disease. Worm (2013) 0.80
Post-translational modifications in mitochondria: protein signaling in the powerhouse. Cell Mol Life Sci (2016) 0.77
O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Sci Rep (2015) 0.77
Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins. Biochem J (2016) 0.75
Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function and survival in HeLa cells. J Biol Chem (2017) 0.75
O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity. Cell Mol Neurobiol (2017) 0.75
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature (2007) 8.48
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology (1992) 5.45
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. Proc Natl Acad Sci U S A (2000) 4.55
Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem (1997) 4.24
The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE (2005) 4.20
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem (1991) 4.16
Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc. Science (2001) 4.13
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (2009) 3.44
O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. J Biol Chem (1997) 3.16
Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats. J Biol Chem (1999) 3.13
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (2002) 3.08
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66
O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta (2009) 2.64
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci U S A (2002) 2.32
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12
Functional expression of O-linked GlcNAc transferase. Domain structure and substrate specificity. J Biol Chem (2000) 2.05
Glycan-dependent signaling: O-linked N-acetylglucosamine. FASEB J (2001) 1.94
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout. Proc Natl Acad Sci U S A (2005) 1.93
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86
O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks. J Cell Biochem (2006) 1.79
Studies on L-glutamine D-fructose 6-phosphate amidotransferase. I. Feedback inhibition by uridine diphosphate-N-acetylglucosamine. J Biol Chem (1967) 1.74
Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system. Cardiovasc Res (2006) 1.74
Two O-linked N-acetylglucosamine transferase genes of Arabidopsis thaliana L. Heynh. have overlapping functions necessary for gamete and seed development. Genetics (2002) 1.72
Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. J Biol Chem (2008) 1.62
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase. J Cell Sci (2003) 1.62
Functional analysis of SPINDLY in gibberellin signaling in Arabidopsis. Plant Physiol (2006) 1.59
Identification of a negative regulator of gibberellin action, HvSPY, in barley. Plant Cell (1998) 1.58
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system. Am J Physiol Heart Circ Physiol (2008) 1.53
Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. EMBO J (2000) 1.51
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proc Natl Acad Sci U S A (2006) 1.51
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene. Arch Biochem Biophys (2003) 1.49
Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2. Am J Physiol Cell Physiol (2008) 1.47
Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc. Am J Physiol Cell Physiol (2006) 1.46
Prospects for research in diabetes mellitus. JAMA (2001) 1.45
Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates. Glycobiology (2006) 1.44
Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death. Proc Natl Acad Sci U S A (2000) 1.39
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins. Proc Assoc Am Physicians (1999) 1.22
Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem (2001) 1.22
Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism. J Neurochem (2004) 1.20
Elevated O-linked N-acetylglucosamine metabolism in pancreatic beta-cells. Arch Biochem Biophys (1999) 1.18
Structure of O-linked GlcNAc transferase: mediator of glycan-dependent signaling. Biochem Biophys Res Commun (2000) 1.13
SECRET AGENT and SPINDLY have overlapping roles in the development of Arabidopsis thaliana L. Heyn. J Exp Bot (2006) 1.02
Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum. Glycobiology (2008) 1.00
Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance. Diabetes (2000) 0.97
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain. J Biol Chem (2006) 0.94
Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol (2009) 0.91
Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection. J Virol (2005) 0.90
Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells. Biochem Biophys Res Commun (2005) 0.86
Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. Leukemia (2002) 0.86
Functional analysis of HvSPY, a negative regulator of GA response, in barley aleurone cells and Arabidopsis. Planta (2008) 0.80
The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE (2005) 4.20
A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A (2003) 2.97
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol (2004) 2.36
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci U S A (2002) 2.32
X chromosome parental origin and aortic stiffness in turner syndrome. Clin Endocrinol (Oxf) (2014) 2.02
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout. Proc Natl Acad Sci U S A (2005) 1.93
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase. J Cell Sci (2003) 1.62
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor. Proc Natl Acad Sci U S A (2006) 1.62
O-GlcNAc cycling: a link between metabolism and chronic disease. Annu Rev Nutr (2013) 1.56
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proc Natl Acad Sci U S A (2006) 1.51
O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol (2010) 1.50
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene. Arch Biochem Biophys (2003) 1.49
A little sugar goes a long way: the cell biology of O-GlcNAc. J Cell Biol (2015) 1.48
Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates. Glycobiology (2006) 1.44
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression. J Clin Invest (2006) 1.37
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination. EMBO J (2005) 1.25
Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology (2003) 1.24
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells. Blood (2005) 1.19
Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem (2012) 1.18
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A (2009) 1.14
Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH. J Virol (2005) 1.13
Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling. J Biol Chem (2007) 1.11
Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate. Carbohydr Res (2006) 1.10
MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria. J Biol Chem (2002) 1.07
Distinctive inhibition of O-GlcNAcase isoforms by an alpha-GlcNAc thiolsulfonate. J Am Chem Soc (2007) 1.04
Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase. J Biol Chem (2005) 1.01
O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases. Proc Natl Acad Sci U S A (2012) 1.00
Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. Mol Cell Biol (2007) 0.99
An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety. J Am Chem Soc (2006) 0.98
Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. J Biol Chem (2010) 0.98
Nutrient-driven O-GlcNAc cycling - think globally but act locally. J Cell Sci (2014) 0.96
Tautomeric modification of GlcNAc-thiazoline. Org Lett (2007) 0.96
A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci (2011) 0.96
O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics (2011) 0.95
The High Mobility Group Box Transcription Factor Nhp6Ap enters the nucleus by a calmodulin-dependent, Ran-independent pathway. J Biol Chem (2007) 0.95
Karyopherin beta3: a new cellular target for the HPV-16 E5 oncoprotein. Biochem Biophys Res Commun (2008) 0.90
Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation. J Biol Chem (2009) 0.89
Mouse mammary tumor virus Env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer. Cancer Res (2005) 0.86
Optimizing the selectivity of DIFO-based reagents for intracellular bioorthogonal applications. Carbohydr Res (2013) 0.86
A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT). Carbohydr Res (2007) 0.86
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem (2005) 0.85
Gelsolin: a novel thyroid hormone receptor-beta interacting protein that modulates tumor progression in a mouse model of follicular thyroid cancer. Endocrinology (2006) 0.83
Nutrient-driven O-GlcNAc cycling influences autophagic flux and neurodegenerative proteotoxicity. Autophagy (2013) 0.83
OGA inhibition by GlcNAc-selenazoline. Bioorg Med Chem (2010) 0.82
Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe. Mol Biol Cell (2002) 0.79
The signal peptide of mouse mammary tumor virus-env: a phosphoprotein tumor modulator. Mol Cancer Res (2012) 0.78
Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug Chem (2014) 0.78
Chemical tools to explore nutrient-driven O-GlcNAc cycling. Crit Rev Biochem Mol Biol (2014) 0.77
You are what you eat: O-linked N-acetylglucosamine in disease, development and epigenetics. Curr Opin Clin Nutr Metab Care (2015) 0.77
Enzymatic characterization of recombinant enzymes of O-GlcNAc cycling. Methods Mol Biol (2013) 0.77
A tribute to G. Gilbert Ashwell. Glycobiology (2015) 0.75
Functions and roles of a protein-associated factor. Cell Biochem Biophys (2014) 0.75