Published in Worm on November 12, 2013
Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes. J Biol Chem (2014) 0.98
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem (2015) 0.97
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A (2016) 0.80
The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease. Biol Direct (2016) 0.80
Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem (2016) 0.76
Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature (2007) 8.48
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem (2011) 4.95
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2002) 4.25
The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE (2005) 4.20
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci U S A (2009) 3.44
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (2009) 3.44
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A (1995) 3.36
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol (2008) 2.76
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol (2012) 2.74
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66
Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011) 2.24
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proc Natl Acad Sci U S A (2009) 2.12
Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol (2011) 2.06
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout. Proc Natl Acad Sci U S A (2005) 1.93
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc Natl Acad Sci U S A (2003) 1.90
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol (2012) 1.89
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86
Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc Natl Acad Sci U S A (1999) 1.84
Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol (1998) 1.80
Protein homeostasis and aging in neurodegeneration. J Cell Biol (2010) 1.76
Regulation of organismal proteostasis by transcellular chaperone signaling. Cell (2013) 1.66
O-GlcNAc cycling: a link between metabolism and chronic disease. Annu Rev Nutr (2013) 1.56
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proc Natl Acad Sci U S A (2006) 1.51
O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol (2010) 1.50
A new DAF-16 isoform regulates longevity. Nature (2010) 1.49
Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res (2012) 1.43
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol (2008) 1.36
Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide. J Biol Chem (2005) 1.23
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
A genetic screening strategy identifies novel regulators of the proteostasis network. PLoS Genet (2011) 1.19
Protein ubiquitination is modulated by O-GlcNAc glycosylation. FASEB J (2008) 1.16
Ageing and protein aggregation-mediated disorders: from invertebrates to mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.03
O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases. Proc Natl Acad Sci U S A (2012) 1.00
Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood. Aging Cell (2013) 0.99
What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Mol Neurodegener (2009) 0.98
Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiol Dis (2010) 0.97
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans. Genetics (2011) 0.94
Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis. Amino Acids (2010) 0.93
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. PLoS One (2012) 0.91
Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Dev Dyn (2010) 0.90
Watching worms whither: modeling neurodegeneration in C. elegans. Prog Mol Biol Transl Sci (2011) 0.86
A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. Neurotherapeutics (2012) 0.84
Nutrient-driven O-GlcNAc cycling influences autophagic flux and neurodegenerative proteotoxicity. Autophagy (2013) 0.83
O-GlcNAc cycling modulates neurodegeneration. Proc Natl Acad Sci U S A (2012) 0.79
Potential neuroprotective strategies against tauopathy. Biochem Soc Trans (2012) 0.76