Published in J Neurooncol on September 19, 2010
The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas. J Transl Med (2014) 0.82
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Stromal fibroblasts in cancer initiation and progression. Nature (2004) 11.69
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer (2006) 8.59
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78
TGF-beta and cancer. Cytokine Growth Factor Rev (2005) 3.38
Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (2002) 3.21
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev (2006) 3.16
Tumor-stroma interactions. Curr Opin Genet Dev (2005) 2.89
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development (2003) 2.78
Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res (2005) 2.63
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol (2010) 2.61
The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci (2007) 2.60
Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia (2004) 2.60
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest (2011) 2.54
Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. J Clin Invest (2007) 2.52
Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene (2005) 2.35
The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer (2013) 2.35
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res (2004) 2.33
A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem (2007) 2.32
Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol (2009) 2.20
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
Does a tree-like phylogeny only exist at the tips in the prokaryotes? Proc Biol Sci (2004) 2.05
Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol (2003) 1.99
Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev (2009) 1.95
Non-stem cell origin for oligodendroglioma. Cancer Cell (2010) 1.95
Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res (2010) 1.83
Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res (2007) 1.81
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol (2010) 1.70
Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. J Clin Invest (2009) 1.68
Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res (2008) 1.64
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res (2004) 1.62
Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J Bone Miner Res (2006) 1.55
TGF-beta signaling is essential for joint morphogenesis. J Cell Biol (2007) 1.51
Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol (2003) 1.46
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog (2011) 1.39
Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development (2006) 1.38
A delicate balance: TGF-beta and the tumor microenvironment. J Cell Biochem (2007) 1.38
Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol (2005) 1.35
Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res (2007) 1.33
Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res (2003) 1.32
Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer? Cancer Res (2008) 1.31
Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res (2007) 1.27
TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov (2011) 1.26
TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest. Proc Natl Acad Sci U S A (2003) 1.25
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev Biol (2005) 1.21
Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene (2005) 1.20
The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia (2003) 1.20
Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis. Cell Cycle (2009) 1.19
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Mol Cell Biol (2002) 1.18
Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas. Cancer Res (2013) 1.16
Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res (2006) 1.16
Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res (2008) 1.15
Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells. Cancer Biol Ther (2007) 1.14
Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc Natl Acad Sci U S A (2011) 1.14
Evidence for heterogeneous selective pressures in the evolution of the env gene in different human immunodeficiency virus type 1 subtypes. J Virol (2005) 1.09
GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res (2009) 1.09
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1. BMC Urol (2008) 1.08
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Res (2012) 1.05
Heterogeneous models place the root of the placental mammal phylogeny. Mol Biol Evol (2013) 1.05
Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. J Neurosci (2010) 1.05
Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes. BMC Genomics (2013) 1.04
Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties. J Leukoc Biol (2012) 1.00
Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts. Prostate (2011) 1.00
p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development (2012) 0.99
Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease. Brain (2013) 0.99
Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals. Cancer Res (2013) 0.96
The Public Goods Hypothesis for the evolution of life on Earth. Biol Direct (2011) 0.96
Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis (2011) 0.95
Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Clin Exp Metastasis (2011) 0.95
Decreased bladder cancer growth in parous mice. Urology (2008) 0.94
Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians. Cancer Epidemiol Biomarkers Prev (2012) 0.94
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors. Am J Pathol (2011) 0.94
Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes. Cell Rep (2013) 0.93
Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. Glia (2012) 0.93
Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS One (2013) 0.93
Turn off the IDO: will clinical trials be successful? Cancer Discov (2012) 0.93
Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem (2007) 0.92
TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution. J Cell Physiol (2009) 0.91
The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions. BMC Evol Biol (2008) 0.91
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J Cell Biochem (2008) 0.90
Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator. BMC Urol (2004) 0.90
ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res (2014) 0.90
Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts. Proteomics (2010) 0.90
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer. Cancer Sci (2013) 0.90
A pluralistic account of homology: adapting the models to the data. Mol Biol Evol (2013) 0.89
Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells. J Neurosci (2012) 0.89
Under pressure: stromal fibroblasts change their ways. Cell (2005) 0.89
CD133/CD140a-based isolation of distinct human multipotent neural progenitor cells and oligodendrocyte progenitor cells. Stem Cells Dev (2013) 0.88
Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis (2005) 0.88
Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling. Am J Physiol Cell Physiol (2011) 0.87
Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway. J Neurosurg (2010) 0.86
Early detection and measurement of urothelial tumors in mice. Urology (2006) 0.85
Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins. BMC Evol Biol (2010) 0.85
Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells. BMC Dev Biol (2009) 0.83
Ageing and CNS remyelination. Neuroreport (2002) 0.83
Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase. Mol Biol Evol (2012) 0.83
A case-by-case evolutionary analysis of four imprinted retrogenes. Evolution (2011) 0.83
Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis. Breast Cancer Res (2014) 0.82