MAL/VIP17, a new player in the regulation of NKCC2 in the kidney.

Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol (2012) 1.59

Molecular regulation of NKCC2 in the thick ascending limb. Am J Physiol Renal Physiol (2011) 1.28

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. J Biol Chem (2012) 1.21

Polarized sorting and trafficking in epithelial cells. Cell Res (2012) 1.06

Physiology and pathophysiology of SLC12A1/2 transporters. Pflugers Arch (2013) 0.96

MAL facilitates the incorporation of exocytic uroplakin-delivering vesicles into the apical membrane of urothelial umbrella cells. Mol Biol Cell (2012) 0.87

High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol (2013) 0.83

NKCC2 is activated in Milan hypertensive rats contributing to the maintenance of salt-sensitive hypertension. Pflugers Arch (2011) 0.81

SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. J Physiol (2016) 0.78

Beyond translation: the renal phosphate census. Focus on "Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule". Am J Physiol Cell Physiol (2011) 0.75

VIP17/MAL expression modulates epithelial cyst formation and ciliogenesis. Am J Physiol Cell Physiol (2012) 0.75

Upregulation of myelin and lymphocyte protein (MAL) after traumatic spinal cord injury in rats. J Mol Histol (2012) 0.75

Regulation of renal Na-(K)-Cl cotransporters by vasopressin. Pflugers Arch (2017) 0.75

CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol (1998) 4.01

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84

Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J (2009) 2.30

A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J Biol Chem (2002) 2.18

VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells. Proc Natl Acad Sci U S A (1999) 2.00

Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem (2003) 1.91

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci U S A (2008) 1.88

Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J Biol Chem (2002) 1.86

EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem (2001) 1.72

MARVEL: a conserved domain involved in membrane apposition events. Trends Biochem Sci (2002) 1.71

Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem (2000) 1.69

The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. J Immunol (1998) 1.69

The MAL proteolipid is necessary for normal apical transport and accurate sorting of the influenza virus hemagglutinin in Madin-Darby canine kidney cells. J Cell Biol (1999) 1.68

Renal Na-K-Cl cotransporter NKCC2 in Dahl salt-sensitive rats. J Hypertens (2002) 1.52

Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J Exp Med (1993) 1.44

Comparison of Na-K-Cl cotransporters. NKCC1, NKCC2, and the HEK cell Na-L-Cl cotransporter. J Biol Chem (1998) 1.37

MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. J Cell Biol (2002) 1.34

Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. J Biol Chem (2000) 1.27

Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem (1998) 1.25

The MAL proteolipid is necessary for the overall apical delivery of membrane proteins in the polarized epithelial Madin-Darby canine kidney and fischer rat thyroid cell lines. Mol Biol Cell (2000) 1.23

MAL decreases the internalization of the aquaporin-2 water channel. Proc Natl Acad Sci U S A (2007) 1.14

Exon loss accounts for differential sorting of Na-K-Cl cotransporters in polarized epithelial cells. Mol Biol Cell (2008) 1.12

The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci U S A (2003) 1.11

MAL mediates apical transport of secretory proteins in polarized epithelial Madin-Darby canine kidney cells. J Biol Chem (2001) 1.06

Activity of the renal Na+-K+-2Cl- cotransporter is reduced by mutagenesis of N-glycosylation sites: role for protein surface charge in Cl- transport. Am J Physiol Renal Physiol (2005) 1.05

Progressive segregation of unmyelinated axons in peripheral nerves, myelin alterations in the CNS, and cyst formation in the kidneys of myelin and lymphocyte protein-overexpressing mice. J Neurochem (2000) 1.03

Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Proc Natl Acad Sci U S A (2002) 1.02

Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers. J Neurochem (2002) 1.02

rMAL is a glycosphingolipid-associated protein of myelin and apical membranes of epithelial cells in kidney and stomach. J Neurosci (1998) 0.97

Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. J Biol Chem (2008) 0.94

Exogenous MAL reroutes selected hepatic apical proteins into the direct pathway in WIF-B cells. Mol Biol Cell (2007) 0.93

Tetraspan proteins: regulators of renal structure and function. Curr Opin Nephrol Hypertens (2007) 0.93

Clustering and lateral concentration of raft lipids by the MAL protein. Mol Biol Cell (2009) 0.92

Late-onset manifestation of antenatal Bartter syndrome as a result of residual function of the mutated renal Na+-K+-2Cl- co-transporter. J Am Soc Nephrol (2006) 0.91

Tetraspanins and vascular functions. Cardiovasc Res (2009) 0.90

Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract. J Clin Gastroenterol (1999) 0.89

Role for protein phosphatase 2A in the regulation of Calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. J Biol Chem (2005) 0.86

Lovastatin-induced cholesterol depletion affects both apical sorting and endocytosis of aquaporin-2 in renal cells. Am J Physiol Renal Physiol (2009) 0.85

Increased expression of the sodium transporter BSC-1 in spontaneously hypertensive rats. J Pharmacol Exp Ther (2004) 0.83

Ion pump-interacting proteins: promising new partners. Ann N Y Acad Sci (2003) 0.83

Developmental expression pattern of the myelin proteolipid MAL indicates different functions of MAL for immature Schwann cells and in a late step of CNS myelinogenesis. J Neurochem (1999) 0.82

Cellular distribution of the renal bumetanide-sensitive Na-K-2Cl cotransporter BSC-1 in the inner stripe of the outer medulla during the development of hypertension in the spontaneously hypertensive rat. Clin Exp Pharmacol Physiol (2007) 0.77

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol (2010) 2.85

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science (2004) 2.39

PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J Biol Chem (2003) 2.34

A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J Biol Chem (2002) 2.18

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A (2013) 2.10

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest (2004) 2.00

AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci U S A (2006) 1.98

Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell (2009) 1.93

Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies. Glia (2009) 1.93

Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J Biol Chem (2003) 1.91

Functional expression of the olfactory signaling system in the kidney. Proc Natl Acad Sci U S A (2009) 1.90

Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J Biol Chem (2002) 1.86

Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. J Neurosci (2010) 1.85

The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials (2009) 1.82

How megalin finds its way: identification of a novel apical sorting motif. Focus on "Identification of an apical sorting determinant in the cytoplasmic tail of megalin". Am J Physiol Cell Physiol (2003) 1.78

Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells. Nat Med (2002) 1.75

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine (2009) 1.72

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. Proc Natl Acad Sci U S A (2004) 1.71

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A (2011) 1.69

Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62

A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic (2006) 1.62

Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2). Am J Physiol Renal Physiol (2005) 1.60

The cell biology of polycystic kidney disease. J Cell Biol (2010) 1.58

IgM deposits on skin nerves in anti-myelin-associated glycoprotein neuropathy. Ann Neurol (2005) 1.56

Minireview: aquaporin 2 trafficking. Endocrinology (2005) 1.49

The aquaporin-2 water channel in autosomal dominant primary nocturnal enuresis. J Urol (2002) 1.46

Regulation of aquaporin-2 trafficking. Handb Exp Pharmacol (2009) 1.45

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy. Sci Transl Med (2012) 1.44

Small-molecule screening identifies modulators of aquaporin-2 trafficking. J Am Soc Nephrol (2013) 1.41

Na+/K+-ATPase β1-subunit is recruited in Na-K-2Cl co-transporter isoform 2 multiprotein complexes in rat kidneys: possible role in blood pressure regulation. J Hypertens (2014) 1.40

Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. J Biol Chem (2003) 1.38

Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol (2011) 1.34

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol (2009) 1.31

Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol (2003) 1.31

Direct reprogramming of human astrocytes into neural stem cells and neurons. Exp Cell Res (2012) 1.26

Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. Am J Physiol Renal Physiol (2011) 1.25

Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain (2007) 1.24

Transport protein trafficking in polarized cells. Annu Rev Cell Dev Biol (2003) 1.24

Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage. Brain Res (2003) 1.23

Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains. Mol Cell Neurosci (2002) 1.22

Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia (2003) 1.21

Changes in gene expression in gills of the euryhaline killifish Fundulus heteroclitus after abrupt salinity transfer. Am J Physiol Cell Physiol (2004) 1.20

Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions. J Biol Chem (2002) 1.19

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A (2011) 1.18

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI. J Cell Sci (2003) 1.18

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol (2011) 1.16

Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin-4. FASEB J (2004) 1.16

The inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water. J Biol Chem (2005) 1.15

MAL decreases the internalization of the aquaporin-2 water channel. Proc Natl Acad Sci U S A (2007) 1.14

Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy. J Clin Microbiol (2011) 1.12

Exon loss accounts for differential sorting of Na-K-Cl cotransporters in polarized epithelial cells. Mol Biol Cell (2008) 1.12

Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane. Am J Physiol Renal Physiol (2002) 1.12

The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci U S A (2003) 1.11

Altered aquaporin-4 expression in human muscular dystrophies: a common feature? FASEB J (2002) 1.10

A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice. Am J Pathol (2005) 1.10

Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding. J Biol Chem (2011) 1.10

Actin remodeling requires ERM function to facilitate AQP2 apical targeting. J Cell Sci (2005) 1.10

Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: implication in orthogonal array formation and neuromyelitis optica antibody interaction. J Biol Chem (2009) 1.09

TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. J Immunol (2010) 1.09

Moderate-to-severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na+-K+-Cl- cotransporter. Am J Physiol Cell Physiol (2005) 1.08

Generation of skeletal muscle cells from embryonic and induced pluripotent stem cells as an in vitro model and for therapy of muscular dystrophies. J Cell Mol Med (2012) 1.08

Hypotonicity induces aquaporin-2 internalization and cytosol-to-membrane translocation of ICln in renal cells. Endocrinology (2006) 1.07

Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer. Cancer Res (2011) 1.07

Automated cell-based assay for screening of aquaporin inhibitors. Anal Chem (2009) 1.06

Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile. Neurobiol Dis (2005) 1.06

Rare mutations in the human Na-K-Cl cotransporter (NKCC2) associated with lower blood pressure exhibit impaired processing and transport function. Am J Physiol Renal Physiol (2011) 1.06

Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse. Brain (2002) 1.06

Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes. FASEB J (2003) 1.06

Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Kidney Int (2004) 1.06

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. J Allergy Clin Immunol (2013) 1.04

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain. J Comp Neurol (2011) 1.04

AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane. J Biol Chem (2011) 1.03

Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells. J Biol Chem (2005) 1.03

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle. Neurobiol Dis (2008) 1.03

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. J Neurosci (2009) 1.03

Polycystic kidney disease: pathogenesis and potential therapies. Biochim Biophys Acta (2010) 1.02

Characterization of two novel missense mutations in the AQP2 gene causing nephrogenic diabetes insipidus. Nephron Physiol (2006) 1.02

Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis. Brain Pathol (2008) 1.02

Mitochondrial fusion proteins and human diseases. Neurol Res Int (2013) 1.02

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J Cell Sci (2003) 1.01

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance. J Physiol (2007) 1.01

Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function. J Lipid Res (2005) 1.00

The residues determining differences in ion affinities among the alternative splice variants F, A, and B of the mammalian renal Na-K-Cl cotransporter (NKCC2). J Biol Chem (2006) 0.99

Intramolecular and intermolecular fluorescence resonance energy transfer in fluorescent protein-tagged Na-K-Cl cotransporter (NKCC1): sensitivity to regulatory conformational change and cell volume. J Biol Chem (2007) 0.99

Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol Pharm (2010) 0.99

Arrestins and spinophilin competitively regulate Na+,K+-ATPase trafficking through association with a large cytoplasmic loop of the Na+,K+-ATPase. Mol Biol Cell (2007) 0.98

Low-calcium diet in hypercalciuric enuretic children restores AQP2 excretion and improves clinical symptoms. Am J Physiol Renal Physiol (2002) 0.97

CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest (2006) 0.97

PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice. J Am Soc Nephrol (2007) 0.97