Published in Tissue Eng Part A on November 09, 2010
Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc Natl Acad Sci U S A (2013) 1.08
The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. Biomaterials (2013) 0.96
Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation. Cell Tissue Res (2011) 0.88
Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications. Drug Discov Today (2014) 0.86
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomater (2014) 0.84
Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling. Biomaterials (2015) 0.83
Delivery of S1P receptor-targeted drugs via biodegradable polymer scaffolds enhances bone regeneration in a critical size cranial defect. J Biomed Mater Res A (2013) 0.83
Changing Paradigms in Cranio-Facial Regeneration: Current and New Strategies for the Activation of Endogenous Stem Cells. Front Physiol (2016) 0.79
Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling. Acta Biomater (2017) 0.77
Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras. Biomaterials (2015) 0.76
Murine spinotrapezius model to assess the impact of arteriolar ligation on microvascular function and remodeling. J Vis Exp (2013) 0.76
Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). PLoS One (2015) 0.76
Delivery of bioactive lipids from composite microgel-microsphere injectable scaffolds enhances stem cell recruitment and skeletal repair. PLoS One (2014) 0.76
Abluminal stimulation of sphingosine 1-phosphate receptors 1 and 3 promotes and stabilizes endothelial sprout formation. Tissue Eng Part A (2014) 0.75
Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev (2004) 16.52
Molecular regulation of vessel maturation. Nat Med (2003) 11.74
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest (2000) 5.48
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 3.07
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem (2003) 2.98
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev (2004) 2.16
Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res (2004) 2.15
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res (2001) 2.04
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell (1999) 2.02
Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res (2006) 1.98
Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol (2000) 1.90
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol (2006) 1.80
Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. J Biol Chem (2004) 1.64
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta (2004) 1.61
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Biochem Biophys Res Commun (2002) 1.53
Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. Am J Physiol Cell Physiol (2000) 1.42
The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.41
High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. Arterioscler Thromb Vasc Biol (2003) 1.41
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development (2005) 1.38
Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2008) 1.37
Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest (2004) 1.26
Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. J Med Chem (2007) 1.22
Cell type-specific localization of human cardiac S1P receptors. J Histochem Cytochem (2002) 1.20
Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle. Microcirculation (2010) 1.11
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. Circ Res (2002) 1.09
Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. Biomaterials (2008) 1.08
Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr Opin Chem Biol (2003) 1.07
Immunohistochemical identification of arteriolar development using markers of smooth muscle differentiation. Evidence that capillary arterialization proceeds from terminal arterioles. Circ Res (1994) 1.07
Arteriolar remodeling following ischemic injury extends from capillary to large arteriole in the microcirculation. Microcirculation (2008) 1.07
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Lett (2008) 1.07
Sphingosine 1-phosphate accelerates wound healing in diabetic mice. J Dermatol Sci (2007) 1.04
FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Eng Part A (2010) 1.04
Arteriogenesis: mechanisms and modulation of collateral artery development. J Nucl Cardiol (2001) 1.01
Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochem Biophys Res Commun (2006) 0.99
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1. J Cell Biochem (2007) 0.97
Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arterioscler Thromb Vasc Biol (2008) 0.94
Spatial and temporal control of angiogenesis and arterialization using focal applications of VEGF164 and Ang-1. Am J Physiol Heart Circ Physiol (2003) 0.94
Growth factor-induced therapeutic neovascularization for ischaemic vascular disease: time for a re-evaluation? Curr Opin Cardiol (2006) 0.92
Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. Prostaglandins Other Lipid Mediat (2004) 0.89
Engineering vascularized tissues using natural and synthetic small molecules. Organogenesis (2008) 0.86
[Arteriogenesis: a new strategy of therapeutic intervention in chronic arterial disorders. Cellular mechanism and experimental models]. Orv Hetil (2007) 0.80
Influence of poly(D,L-lactic-co-glycolic acid) microsphere degradation on arteriolar remodeling in the mouse dorsal skinfold window chamber. J Biomed Mater Res A (2009) 0.79
Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev (2004) 16.52
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem (2002) 6.96
Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res (2003) 3.99
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 3.07
International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev (2002) 2.75
Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem (2004) 2.63
Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells. Circ Res (2005) 2.45
Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med (2010) 2.40
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol (2006) 2.39
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res (2010) 2.04
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J Clin Invest (2006) 2.04
Differential arterial/venous expression of NG2 proteoglycan in perivascular cells along microvessels: identifying a venule-specific phenotype. Microcirculation (2005) 2.01
Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J Biol Chem (2005) 1.84
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol (2002) 1.79
Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res (2009) 1.78
Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. Circ Res (2007) 1.76
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem (2006) 1.70
Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am J Physiol Cell Physiol (2007) 1.70
5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. J Clin Invest (2005) 1.62
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use. J Cell Mol Med (2009) 1.59
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res (2008) 1.51
A compartment model of VEGF distribution in blood, healthy and diseased tissues. BMC Syst Biol (2008) 1.50
Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4). Mol Pharmacol (2002) 1.39
Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. Biochem J (2009) 1.38
Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2008) 1.37
Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. Proc Natl Acad Sci U S A (2004) 1.31
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol (2010) 1.31
Combining experiments with multi-cell agent-based modeling to study biological tissue patterning. Brief Bioinform (2007) 1.29
Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells. Stem Cells (2006) 1.29
Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. J Med Chem (2010) 1.28
Multiscale models of angiogenesis. IEEE Eng Med Biol Mag (2009) 1.26
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler Thromb Vasc Biol (2005) 1.26
Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery. Tissue Eng Part A (2010) 1.25
Multi-cell agent-based simulation of the microvasculature to study the dynamics of circulating inflammatory cell trafficking. Ann Biomed Eng (2007) 1.23
IFATS collection: The role of human adipose-derived stromal cells in inflammatory microvascular remodeling and evidence of a perivascular phenotype. Stem Cells (2008) 1.22
Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. J Med Chem (2007) 1.22
Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model. Cancer Res (2010) 1.22
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem (2011) 1.21
Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles. J Vasc Res (2009) 1.19
Perivascular cells along venules upregulate NG2 expression during microvascular remodeling. Microcirculation (2006) 1.17
Origin of neointimal smooth muscle: we've come full circle. Arterioscler Thromb Vasc Biol (2006) 1.17
Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol (2008) 1.15
Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5). Am J Physiol Cell Physiol (2011) 1.15
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+). Am J Physiol Endocrinol Metab (2002) 1.14
PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. Am J Physiol Heart Circ Physiol (2008) 1.12
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem (2003) 1.11
Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine. J Appl Physiol (1985) (2006) 1.11
Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorg Med Chem Lett (2004) 1.11
Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle. Microcirculation (2010) 1.11
Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem J (2005) 1.10
Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. J Biomed Mater Res A (2009) 1.10
Multiscale computational models of complex biological systems. Annu Rev Biomed Eng (2013) 1.10
A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap. PLoS One (2009) 1.09
Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia. Arterioscler Thromb Vasc Biol (2009) 1.08
Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proc Natl Acad Sci U S A (2013) 1.08
Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. Biomaterials (2008) 1.08
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. Biochem J (2012) 1.08
Novel human G-protein-coupled receptors. Biochem Biophys Res Commun (2003) 1.08
S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett (2009) 1.08
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Lett (2008) 1.07
Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine. Comp Med (2003) 1.07
Arteriolar remodeling following ischemic injury extends from capillary to large arteriole in the microcirculation. Microcirculation (2008) 1.07
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int (2008) 1.07
Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling. Trends Immunol (2008) 1.06
The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. J Biol Chem (2009) 1.06
Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorg Med Chem Lett (2003) 1.06
Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res (2008) 1.06
Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis (2008) 1.05
Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin. PLoS Comput Biol (2009) 1.05
Module-based multiscale simulation of angiogenesis in skeletal muscle. Theor Biol Med Model (2011) 1.04
Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy. PLoS One (2013) 1.04
FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Eng Part A (2010) 1.04
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorg Med Chem (2011) 1.03
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorg Med Chem Lett (2005) 1.02
Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis. Dev Biol (2004) 1.02
Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorg Med Chem Lett (2004) 1.02
A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorg Med Chem Lett (2004) 1.01
EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker. Microcirculation (2007) 1.01
Endothelial cell-dependent regulation of arteriogenesis. Circ Res (2013) 1.00
Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Mol Carcinog (2009) 1.00
Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery. Ultrasound Med Biol (2010) 1.00
Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. Biochem J (2011) 0.99
Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes. Tissue Eng Part C Methods (2009) 0.99
Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation. J Control Release (2011) 0.99
Vascular assembly in natural and engineered tissues. Ann N Y Acad Sci (2002) 0.99
Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo. J Pharmacol Exp Ther (2010) 0.99
Hemodynamic activation of beta-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression. Arterioscler Thromb Vasc Biol (2011) 0.99
Lost in transdifferentiation. J Clin Invest (2004) 0.98
Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. BMC Syst Biol (2007) 0.98
Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes (2007) 0.97
A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Anal Biochem (2011) 0.97
Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise. Am J Physiol Heart Circ Physiol (2007) 0.97
Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation. Arterioscler Thromb Vasc Biol (2011) 0.97
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. Hum Mol Genet (2009) 0.97
Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Curr Pharm Des (2013) 0.97