Published in J Biol Chem on August 10, 2005
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Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. J Med Chem (2007) 1.22
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Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int (2012) 0.88
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Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition. J Biol Chem (2009) 0.85
Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorg Med Chem (2009) 0.85
Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures. PLoS One (2014) 0.82
The emerging role of FTY720 (Fingolimod) in cancer treatment. Oncotarget (2016) 0.82
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Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation (2015) 0.79
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Sphingolipids: a potential molecular approach to treat allergic inflammation. J Allergy (Cairo) (2012) 0.76
The role of sphingosine 1-phosphate in immunity and sepsis. Am J Clin Exp Immunol (2012) 0.75
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ. J Am Soc Nephrol (2016) 0.75
Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. FASEB J (2015) 0.75
Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. Adv Biol Regul (2016) 0.75
"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. Int J Mol Sci (2017) 0.75
Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem (2002) 6.96
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity (2005) 6.71
Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol (2009) 5.28
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02
Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 3.83
Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays. Bioinformatics (2003) 3.75
Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med (2006) 3.65
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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest (2006) 3.38
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med (2002) 3.17
Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 3.07
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J Immunol (2007) 2.92
Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J Clin Invest (2006) 2.76
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Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation (2002) 2.69
Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation (2010) 2.69
Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res (2004) 2.68
Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells. J Clin Oncol (2003) 2.67
Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem (2004) 2.63
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med (2006) 2.62
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58
P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest (2002) 2.45
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med (2010) 2.44
Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity (2007) 2.43
Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med (2010) 2.40
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol (2006) 2.39
NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res (2011) 2.38
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell (2012) 2.38
Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2005) 2.28
Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends Cardiovasc Med (2008) 2.22
Bacterial colonization factors control specificity and stability of the gut microbiota. Nature (2013) 2.20
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell (2013) 2.18
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood (2011) 2.17
Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice. Circulation (2003) 2.11
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Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats. Arthritis Rheum (2012) 2.10
Platelet-neutrophil-interactions: linking hemostasis and inflammation. Blood Rev (2006) 2.08
Preferential migration of effector CD8+ T cells into the interstitium of the normal lung. J Clin Invest (2005) 2.07
M1 and M2 macrophages: the chicken and the egg of immunity. J Innate Immun (2014) 2.06
Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. J Immunol (2007) 2.05
Considerations in the development of circulating tumor cell technology for clinical use. J Transl Med (2012) 2.00
Protective effects of isoflurane pretreatment in endotoxin-induced lung injury. Anesthesiology (2006) 1.99
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med (2010) 1.97
The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med (2006) 1.96
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes (2007) 1.96
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood (2012) 1.95
Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Blood (2002) 1.92
Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo. Biophys J (2003) 1.90
CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med (2004) 1.89
Leukocyte recruitment and vascular injury in diabetic nephropathy. J Am Soc Nephrol (2006) 1.89
Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med (2005) 1.88
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87
Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability. Trends Immunol (2009) 1.82
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release (2004) 1.81
Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. Circ Res (2006) 1.81
Homeostatic regulation of blood neutrophil counts. J Immunol (2008) 1.81
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol (2002) 1.79
Macrophage differentiation to foam cells. Curr Pharm Des (2005) 1.77
Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. Proc Natl Acad Sci U S A (2004) 1.77
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.76
P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med (2003) 1.73
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The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood (2003) 1.70
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol (2012) 1.70
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med (2004) 1.70
Systems genetics analysis of gene-by-environment interactions in human cells. Am J Hum Genet (2010) 1.69
Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. J Exp Med (2003) 1.68
Neutrophil adhesion and activation under flow. Microcirculation (2009) 1.67
Tracking leukocytes in vivo with shape and size constrained active contours. IEEE Trans Med Imaging (2002) 1.67
Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells. Curr Opin Cell Biol (2008) 1.67
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. J Immunol (2007) 1.62
Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation. Blood (2010) 1.61
Glycosylation in immune cell trafficking. Immunol Rev (2009) 1.61
Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest (2012) 1.57
Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung. Crit Care (2004) 1.57
Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal (2011) 1.51
Induction of dendritic cell-like phenotype in macrophages during foam cell formation. Physiol Genomics (2007) 1.51
Platelet chemokines in vascular disease. Arterioscler Thromb Vasc Biol (2008) 1.51
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res (2008) 1.51
Sialyltransferase specificity in selectin ligand formation. Blood (2002) 1.50
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest (2004) 1.50