PubRank

Kendall W Nettles

Author PubWeight™ 19.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure 2007 2.57
2 Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat Struct Biol 2002 1.83
3 Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands. Chem Biol 2007 1.31
4 Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol 2010 1.25
5 Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. J Med Chem 2007 1.01
6 Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations. Biochemistry 2011 1.00
7 Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α. Nat Chem Biol 2013 0.96
8 Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands. ChemMedChem 2012 0.94
9 Creb coactivators direct anabolic responses and enhance performance of skeletal muscle. EMBO J 2014 0.91
10 Thiophene-core estrogen receptor ligands having superagonist activity. J Med Chem 2013 0.88
11 Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide. J Med Chem 2012 0.87
12 Insights into PPARgamma from structures with endogenous and covalently bound ligands. Nat Struct Mol Biol 2008 0.87
13 Improved crystallographic structures using extensive combinatorial refinement. Structure 2013 0.87
14 Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure 2012 0.86
15 Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides. Org Biomol Chem 2012 0.85
16 A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem 2011 0.85
17 The nuclear receptor signalling scaffold: insights from full-length structures. EMBO J 2012 0.82
18 Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor. J Med Chem 2014 0.80
19 Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor (ER)-Mediated Activities in Breast Cancer Cells. J Med Chem 2017 0.76
20 Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat Chem Biol 2017 0.75
21 Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nat Chem Biol 2017 0.75