Published in Biochem Biophys Res Commun on October 16, 2010
Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med (2011) 1.40
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene (2011) 1.38
MicroRNAs involved in bone formation. Cell Mol Life Sci (2014) 0.92
Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators? Front Genet (2012) 0.92
MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep (2014) 0.89
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease. World J Biol Chem (2015) 0.87
MicroRNAs associated with osteoarthritis differently expressed in bone matrix gelatin (BMG) rat model. Int J Clin Exp Med (2015) 0.82
Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes. J Histochem Cytochem (2012) 0.80
The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone. Acta Orthop (2014) 0.79
The Role of miRNAs in Cartilage Homeostasis. Curr Genomics (2015) 0.75
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet (2007) 4.31
Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. J Biol Chem (2002) 1.80
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. J Am Soc Nephrol (2004) 1.70
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55
Ex vivo real-time observation of Ca(2+) signaling in living bone in response to shear stress applied on the bone surface. Bone (2012) 1.55
A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev. Virology (2004) 1.54
Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. J Am Soc Nephrol (2004) 1.53
Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J Bone Miner Res (2008) 1.51
Role of CTGF/HCS24/ecogenin in skeletal growth control. J Cell Physiol (2003) 1.50
Angiogenesis in cancer. Vasc Health Risk Manag (2006) 1.49
Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res (2006) 1.45
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J Clin Invest (2011) 1.42
Class III malocclusion with complex problems of lateral open bite and severe crowding successfully treated with miniscrew anchorage and lingual orthodontic brackets. Am J Orthod Dentofacial Orthop (2011) 1.42
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett (2006) 1.38
CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis (2006) 1.36
Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma. Cancer (2004) 1.33
Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol (2004) 1.32
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol (2003) 1.32
Role of CCN2/CTGF/Hcs24 in bone growth. Int Rev Cytol (2007) 1.30
Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol (2005) 1.28
AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol (2003) 1.27
Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis. Hypertension (2007) 1.26
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. Carcinogenesis (2002) 1.23
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res (2004) 1.23
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol Cell Biol (2008) 1.19
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes. J Cell Physiol (2002) 1.15
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene. FEBS Lett (2009) 1.15
Lower extremity nerve function in patients with lower extremity ischemia. Arch Intern Med (2006) 1.14
Asymptomatic peripheral arterial disease is associated with more adverse lower extremity characteristics than intermittent claudication. Circulation (2008) 1.12
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J (2007) 1.11
Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol (2006) 1.10
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure. Eur J Heart Fail (2008) 1.07
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Biochim Biophys Acta (2002) 1.06
A method for observing silver-stained osteocytes in situ in 3-microm sections using ultra-high voltage electron microscopy tomography. Microsc Microanal (2009) 1.06
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan. Biochem J (2009) 1.05
Comparison of orthodontic treatment outcomes in adults with skeletal open bite between conventional edgewise treatment and implant-anchored orthodontics. Am J Orthod Dentofacial Orthop (2011) 1.04
Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology (2004) 1.03
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun (2007) 1.03
Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol (2006) 1.02
Distal movement of maxillary molars using miniscrew anchorage in the buccal interradicular region. Angle Orthod (2009) 1.00
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA. Biochem Biophys Res Commun (2011) 1.00
Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways. Bone (2011) 0.99
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. J Biochem (2004) 0.99
Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy. J Neurol Sci (2007) 0.97
Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis Cartilage (2004) 0.97
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res (2011) 0.96
Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes. J Cell Commun Signal (2014) 0.96
The role of CCN2 in cartilage and bone development. J Cell Commun Signal (2011) 0.96
Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. Bone (2007) 0.95
PTHrP regulates angiogenesis and bone resorption via VEGF expression. Anticancer Res (2010) 0.94
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes. Bone (2006) 0.94
Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. J Biol Chem (2005) 0.94
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line. Cancer Lett (2003) 0.93
Vaccination with predesignated or evidence-based peptides for patients with recurrent gynecologic cancers. J Immunother (2003) 0.92
The three-dimensional morphometry and cell-cell communication of the osteocyte network in chick and mouse embryonic calvaria. Calcif Tissue Int (2011) 0.92
Role of LRP1 in transport of CCN2 protein in chondrocytes. J Cell Sci (2012) 0.92