Published in Biochemistry on November 01, 1977
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Site-specific DNA-affinity chromatography of the lac repressor. Nucleic Acids Res (1980) 1.85
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Binding of lac repressor-GFP fusion protein to lac operator sites inserted in the tobacco chloroplast genome examined by chromatin immunoprecipitation. Nucleic Acids Res (2010) 0.82
Macromolecular competition titration method accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs. Methods Enzymol (2011) 0.81
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Interaction of the tight-binding I12-X86 lac repressor with non operator DNA: salt dependence of complex formation. Nucleic Acids Res (1986) 0.75
Method for trapping affinity chromatography of transcription factors using aldehyde-hydrazide coupling to agarose. Anal Biochem (2015) 0.75
Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem (1989) 29.15
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res (1981) 24.41
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Diffusion-controlled macromolecular interactions. Annu Rev Biophys Biophys Chem (1985) 4.87
Betaine can eliminate the base pair composition dependence of DNA melting. Biochemistry (1993) 4.35
Selection of DNA binding sites by regulatory proteins. II. The binding specificity of cyclic AMP receptor protein to recognition sites. J Mol Biol (1988) 3.99
Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspects. Proc Natl Acad Sci U S A (1974) 3.45
Multiple RNA polymerase conformations and GreA: control of the fidelity of transcription. Science (1993) 3.12
On the specificity of DNA-protein interactions. Proc Natl Acad Sci U S A (1986) 3.11
Diffusion-driven mechanisms of protein translocation on nucleic acids. 2. The Escherichia coli repressor--operator interaction: equilibrium measurements. Biochemistry (1981) 2.98
Nonspecific DNA binding of genome-regulating proteins as a biological control mechanism: measurement of DNA-bound Escherichia coli lac repressor in vivo. Proc Natl Acad Sci U S A (1977) 2.70
Action at a distance: DNA-looping and initiation of transcription. Trends Biochem Sci (1995) 2.64
Transcription termination at intrinsic terminators: the role of the RNA hairpin. Proc Natl Acad Sci U S A (1995) 2.61
A thermodynamic analysis of RNA transcript elongation and termination in Escherichia coli. Biochemistry (1991) 2.38
Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids. I. Characterization of the binding interactions. J Mol Biol (1981) 2.19
Cooperative binding to DNA of catabolite activator protein of Escherichia coli. Biochemistry (1979) 2.15
Escherichia coli sigma 70 and NusA proteins. I. Binding interactions with core RNA polymerase in solution and within the transcription complex. J Mol Biol (1991) 2.09
Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases. Biochemistry (1975) 1.93
Cooperative and noncooperative binding of protein ligands to nucleic acid lattices: experimental approaches to the determination of thermodynamic parameters. Biochemistry (1986) 1.89
Effects of methylation on the stability of nucleic acid conformations: studies at the monomer level. Biochemistry (1974) 1.88
The single-nucleotide addition cycle in transcription: a biophysical and biochemical perspective. Annu Rev Biophys Biomol Struct (1992) 1.81
Climate change and the integrity of science. Science (2010) 1.80
Transcriptional activation via DNA-looping: visualization of intermediates in the activation pathway of E. coli RNA polymerase x sigma 54 holoenzyme by scanning force microscopy. J Mol Biol (1997) 1.79
Selection of DNA binding sites by regulatory proteins. Trends Biochem Sci (1988) 1.73
Functional transcription elongation complexes from synthetic RNA-DNA bubble duplexes. Science (1992) 1.65
Effects of methylation on the stability of nucleic acid conformations. Studies at the polymer level. J Biol Chem (1978) 1.64
Quantitation of the interaction of EScherichia coli RNA polymerase holoenzyme with double-helical DNA using a thermodynamically rigorous centrifugation method. Biochemistry (1981) 1.60
DNA "melting" proteins. IV. Fluorescence measurements of binding parameters for bacteriophage T4 gene 32-protein to mono-, oligo-, and polynucleotides. J Biol Chem (1976) 1.58
The phage T4-coded DNA replication helicase (gp41) forms a hexamer upon activation by nucleoside triphosphate. J Biol Chem (1995) 1.58
Autoregulation of gene expression. Quantitative evaluation of the expression and function of the bacteriophage T4 gene 32 (single-stranded DNA binding) protein system. J Mol Biol (1982) 1.57
Laser cross-linking of nucleic acids to proteins. Methodology and first applications to the phage T4 DNA replication system. J Biol Chem (1986) 1.54
Proposed changes for NIH's Center for Scientific Review. Panel on Scientific Boundaries for Review. Center for Scientific Review Advisory Committee, National Institutes of Health. Science (1999) 1.52
Structural and enzymatic studies of the T4 DNA replication system. II. ATPase properties of the polymerase accessory protein complex. J Biol Chem (1989) 1.52
RNA sequence and secondary structure requirements for rho-dependent transcription termination. Nucleic Acids Res (1985) 1.48
Two catabolite activator protein molecules bind to the galactose promoter region of Escherichia coli in the presence of RNA polymerase. Proc Natl Acad Sci U S A (1983) 1.47
Structure and function of the bacteriophage T4 DNA polymerase holoenzyme. Biochemistry (1992) 1.46
On the determination of deoxyribonucleic acid-protein interaction parameters using the nitrocellulose filter-binding assay. Biochemistry (1983) 1.45
Formaldehyde as a probe of DNA structure. r. Mechanism of the initial reaction of Formaldehyde with DNA. Biochemistry (1977) 1.45
"Macromolecular crowding": thermodynamic consequences for protein-protein interactions within the T4 DNA replication complex. J Biol Chem (1990) 1.43
Rho-dependent termination of transcription. II. Kinetics of mRNA elongation during transcription from the bacteriophage lambda PR promoter. J Biol Chem (1983) 1.42
Hydrogen exchange as a probe of the dynamic structure of DNA. I. General acid-base catalysis. J Mol Biol (1970) 1.41
Structural and enzymatic studies of the T4 DNA replication system. I. Physical characterization of the polymerase accessory protein complex. J Biol Chem (1989) 1.40
Stoichiometry of catabolite activator protein/adenosine cyclic 3',5'-monophosphate interactions at the lac promoter of Escherichia coli. Biochemistry (1982) 1.40
DNA "melting" proteins. II. Effects of bacteriophage T4 gene 32-protein binding on the conformation and stability of nucleic acid structures. J Biol Chem (1976) 1.39
Rho-dependent termination of transcription. I. Identification and characterization of termination sites for transcription from the bacteriophage lambda PR promoter. J Biol Chem (1983) 1.35
DNA site recognition and reduced specificity of the Eco RI endonuclease. J Biol Chem (1980) 1.35
Molecular mechanisms of the functional coupling of the helicase (gp41) and polymerase (gp43) of bacteriophage T4 within the DNA replication fork. Biochemistry (2001) 1.35
Regulation of rho-dependent transcription termination by NusG is specific to the Escherichia coli elongation complex. Biochemistry (2000) 1.32
Structure and assembly of the Escherichia coli transcription termination factor rho and its interaction with RNA. I. Cryoelectron microscopic studies. J Mol Biol (1991) 1.29
Kinetic theory of ATP-driven translocases on one-dimensional polymer lattices. J Mol Biol (1994) 1.28
DNA "melting" proteins. I. Effects of bovine pancreatic ribonuclease binding on the conformation and stability of DNA. J Biol Chem (1976) 1.27
Nucleic acid binding properties of Escherichia coli ribosomal protein S1. I. Structure and interactions of binding site I. J Mol Biol (1978) 1.27
A physical model for the translocation and helicase activities of Escherichia coli transcription termination protein Rho. Proc Natl Acad Sci U S A (1993) 1.27
Nucleic acid binding properties of Escherichia coli ribosomal protein S1. II. Co-operativity and specificity of binding site II. J Mol Biol (1978) 1.26
Stability of Escherichia coli transcription complexes near an intrinsic terminator. J Mol Biol (1994) 1.25
Formaldehyde as a probe of DNA structure. 3. Equilibrium denaturation of DNA and synthetic polynucleotides. Biochemistry (1977) 1.24
RNA displacement pathways during transcription from synthetic RNA-DNA bubble duplexes. Biochemistry (1994) 1.24
Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids. III. Binding properties of two specific proteolytic digestion products of the protein (G32P*I and G32P*III). J Mol Biol (1981) 1.23
Laser cross-linking of protein-nucleic acid complexes. Methods Enzymol (1991) 1.23
Interactions of Escherichia coli transcription termination factor rho with RNA. II. Electron microscopy and nuclease protection experiments. J Mol Biol (1988) 1.22
Binding of E.coli lac repressor to non-operator DNA. Nucleic Acids Res (1977) 1.22
Interactions of Escherichia coli transcription termination factor rho with RNA. I. Binding stoichiometries and free energies. J Mol Biol (1988) 1.19
Physical properties of the Escherichia coli transcription termination factor rho. 1. Association states and geometry of the rho hexamer. Biochemistry (1992) 1.18
The functional and physical form of mammalian cytochrome c oxidase determined by gel filtration, radiation inactivation, and sedimentation equilibrium analysis. J Biol Chem (1984) 1.18
The ATP-activated hexameric helicase of bacteriophage T4 (gp41) forms a stable primosome with a single subunit of T4-coded primase (gp61). J Biol Chem (1996) 1.18
Processive proofreading is intrinsic to T4 DNA polymerase. J Biol Chem (1992) 1.18
Kinetic parameters of the translocation of bacteriophage T4 gene 41 protein helicase on single-stranded DNA. J Mol Biol (1994) 1.18
Regulation of the elongation-termination decision at intrinsic terminators by antitermination protein N of phage lambda. J Mol Biol (1997) 1.17
Assembly of a functional replication complex without ATP hydrolysis: a direct interaction of bacteriophage T4 gp45 with T4 DNA polymerase. Proc Natl Acad Sci U S A (1993) 1.16
Bacteriophage lambda N protein alone can induce transcription antitermination in vitro. Proc Natl Acad Sci U S A (1996) 1.16
Specificity of release by Escherichia coli transcription termination factor rho of nascent mRNA transcripts initiated at the lambda PR. J Biol Chem (1984) 1.15
Molecular parameters characterizing the interaction of Escherichia coli lac repressor with non-operator DNA and inducer. Biochemistry (1977) 1.14
Formaldehyde as a probe of DNA structure. II. Reaction with endocyclic imino groups of DNA bases. Biochemistry (1975) 1.14
Comparison of nucleic acid-protein interactions in solution and in polyacrylamide gels. Anal Biochem (1986) 1.13
On the processivity of DNA replication. J Biomol Struct Dyn (1983) 1.11
Kinetics of RNA polymerase-promoter complex formation: effects of nonspecific DNA-protein interactions. Nucleic Acids Res (1984) 1.10
Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids. II. Specificity of binding to DNA and RNA. J Mol Biol (1981) 1.10
DNA "melting" proteins. III. Fluorescence "mapping" of the nucleic acid binding site of bacteriophage T4 gene 32-protein. J Biol Chem (1976) 1.09
Escherichia coli transcription termination factor rho. II. Binding of oligonucleotide cofactors. J Biol Chem (1993) 1.09
Physical properties of the Escherichia coli transcription termination factor rho. 2. Quaternary structure of the rho hexamer. Biochemistry (1992) 1.07
Cryoelectron microscopic visualization of functional subassemblies of the bacteriophage T4 DNA replication complex. J Mol Biol (1992) 1.07
Functional interactions of ligand cofactors with Escherichia coli transcription termination factor rho. I. Binding of ATP. Protein Sci (1992) 1.07
A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate. Proc Natl Acad Sci U S A (1998) 1.06
Complexes of N antitermination protein of phage lambda with specific and nonspecific RNA target sites on the nascent transcript. Biochemistry (1997) 1.05
Escherichia coli ribosomal protein S1 has two polynucleotide binding sites. Proc Natl Acad Sci U S A (1977) 1.04
Hydrogen exchange as a probe of the dynamic structure of DNA. II. Effects of base composition and destabilizing salts. J Mol Biol (1970) 1.03
DNA site recognition and overmethylation by the Eco RI methylase. J Biol Chem (1980) 1.02
Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism. Proc Natl Acad Sci U S A (1997) 1.02
The binding of catabolite activator protein and RNA polymerase to the Escherichia coli galactose and lactose promoters probed by alkylation interference studies. J Biol Chem (1986) 1.02
On the thermodynamics and kinetics of the cooperative binding of bacteriophage T4-coded gene 32 (helix destabilizing) protein to nucleic acid lattices. Biophys J (1980) 1.00
Dissection of the ATP-driven reaction cycle of the bacteriophage T4 DNA replication processivity clamp loading system. J Mol Biol (2001) 1.00
A coupled complex of T4 DNA replication helicase (gp41) and polymerase (gp43) can perform rapid and processive DNA strand-displacement synthesis. Proc Natl Acad Sci U S A (1996) 1.00