Published in Curr Opin Biotechnol on December 01, 2010
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients. PLoS Pathog (2013) 2.16
Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem (2012) 1.85
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The expanding role of marine microbes in pharmaceutical development. Curr Opin Biotechnol (2010) 1.30
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"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo. Oncotarget (2012) 0.95
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Microbial natural products: molecular blueprints for antitumor drugs. J Ind Microbiol Biotechnol (2013) 0.84
Latitudinal variation of a defensive symbiosis in the Bugula neritina (Bryozoa) sibling species complex. PLoS One (2014) 0.81
Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery. Mar Drugs (2014) 0.80
Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway. J Nat Prod (2016) 0.79
Recent advances in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep (2016) 0.79
Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs. Tetrahedron (2011) 0.79
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Inferring metabolic pathway activity levels from RNA-Seq data. BMC Genomics (2016) 0.75
Single sample resolution of rare microbial dark matter in a marine invertebrate metagenome. Sci Rep (2016) 0.75
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations. Mar Drugs (2017) 0.75
In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. PLoS Pathog (2017) 0.75
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Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02
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Function-oriented synthesis, step economy, and drug design. Acc Chem Res (2007) 3.00
Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J Nat Prod (2007) 2.45
The chemistry and biology of the bryostatin antitumour macrolides. Nat Prod Rep (2002) 2.38
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol (2008) 2.35
Tracing the evolution of gene loss in obligate bacterial symbionts. Curr Opin Microbiol (2003) 2.25
Biosynthesis of polyketides by trans-AT polyketide synthases. Nat Prod Rep (2010) 2.10
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice. Proc Natl Acad Sci U S A (2004) 2.00
Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. PLoS One (2010) 1.95
Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina. Appl Environ Microbiol (2001) 1.94
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Potent cytotoxins produced by a microbial symbiont protect host larvae from predation. Oecologia (2004) 1.48
Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains. Proc Natl Acad Sci U S A (2008) 1.42
The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). PLoS One (2009) 1.28
bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol (2004) 1.27
Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins and harbor distinct strains of the bacterial symbiont "Candidatus Endobugula sertula". Biol Bull (1999) 1.24
New approaches to the total synthesis of the bryostatin antitumor macrolides. Chem Asian J (2010) 1.24
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters. Org Lett (2009) 1.20
Dual effects of bryostatin-1 on spatial memory and depression. Eur J Pharmacol (2005) 1.16
Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics. Biomol Eng (2003) 1.14
"Candidatus Endobugula glebosa," a specific bacterial symbiont of the marine bryozoan Bugula simplex. Appl Environ Microbiol (2004) 1.11
Cryptic species, cryptic endosymbionts, and geographical variation in chemical defences in the bryozoan Bugula neritina. Mol Ecol (2003) 1.09
Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina. ISME J (2007) 1.09
Approaches to identify, clone, and express symbiont bioactive metabolite genes. Nat Prod Rep (2003) 1.05
Neuroprotective versus tumorigenic protein kinase C activators. Trends Biochem Sci (2009) 1.04
Structure of bryostatin 20: a symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina. J Nat Prod (2004) 1.03
In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol (2008) 1.03
Postischemic PKC activation rescues retrograde and anterograde long-term memory. Proc Natl Acad Sci U S A (2009) 0.99
Evolutionary relationships of "Candidatus endobugula" bacterial symbionts and their Bugula bryozoan hosts. Appl Environ Microbiol (2008) 0.96
Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus. Appl Environ Microbiol (2006) 0.95
Recombinational transfer of 100-kilobase genomic DNA to plasmid in Bacillus subtilis 168. J Bacteriol (2001) 0.91
Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats. Eur J Pharmacol (2008) 0.85
Protein kinase C activators as synaptogenic and memory therapeutics. Arch Pharm (Weinheim) (2009) 0.83
Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response. Behav Pharmacol (2008) 0.81
Naturally occurring esterification reactions with bryostatin. Nat Prod Res (2008) 0.81
Impact of environmental conditions on the marine natural product bryostatin 1. Nat Prod Res (2006) 0.80
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A (2005) 5.02
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nat Chem Biol (2006) 4.12
Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J Nat Prod (2007) 2.45
Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence. Appl Environ Microbiol (2006) 2.07
Vertical transmission of diverse microbes in the tropical sponge Corticium sp. Appl Environ Microbiol (2006) 1.62
Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium. Proc Natl Acad Sci U S A (2003) 1.41
The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). PLoS One (2009) 1.28
Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis. Proc Natl Acad Sci U S A (2011) 1.25
Structure and membrane affinity of new amphiphilic siderophores produced by Ochrobactrum sp. SP18. J Biol Inorg Chem (2006) 1.21
Investigation of Oscillatoria spongeliae-dominated bacterial communities in four dictyoceratid sponges. Appl Environ Microbiol (2005) 1.17
"Candidatus Endobugula glebosa," a specific bacterial symbiont of the marine bryozoan Bugula simplex. Appl Environ Microbiol (2004) 1.11
Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian. J Nat Prod (2004) 1.10
A bacterial source for mollusk pyrone polyketides. Chem Biol (2013) 1.09
Genome streamlining and chemical defense in a coral reef symbiosis. Proc Natl Acad Sci U S A (2012) 1.09
Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina. ISME J (2007) 1.09
Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae. Chem Biol (2005) 1.06
Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. J Nat Prod (2010) 1.05
Approaches to identify, clone, and express symbiont bioactive metabolite genes. Nat Prod Rep (2003) 1.05
In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol (2008) 1.03
Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. J Med Chem (2011) 1.02
Marine chemical ecology in benthic environments. Nat Prod Rep (2014) 0.97
Evolutionary relationships of "Candidatus endobugula" bacterial symbionts and their Bugula bryozoan hosts. Appl Environ Microbiol (2008) 0.96
Genome sequence of the marine bacterium Vibrio campbellii DS40M4, isolated from open ocean water. J Bacteriol (2012) 0.92
Acquisition of iron by Trichodesmium and associated bacteria in culture. Environ Microbiol (2011) 0.90
Alpha-proteobacterial symbionts of marine bryozoans in the genus Watersipora. Appl Environ Microbiol (2006) 0.86
Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp. J Nat Prod (2012) 0.86
Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proc Natl Acad Sci U S A (2013) 0.84
Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS One (2012) 0.83
Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorg Med Chem Lett (2013) 0.82
Biosynthesis of amphi-enterobactin siderophores by Vibrio harveyi BAA-1116: identification of a bifunctional nonribosomal peptide synthetase condensation domain. J Am Chem Soc (2014) 0.79
Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Mol Ecol (2014) 0.77
Turnerbactin, a novel triscatecholate siderophore from the shipworm endosymbiont Teredinibacter turnerae T7901. PLoS One (2013) 0.77
Fatty acid hydrolysis of acyl marinobactin siderophores by Marinobacter acylases. Biochemistry (2015) 0.76
Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. J Nat Prod (2014) 0.75
Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products. J Nat Prod (2017) 0.75