Published in J Mol Cell Cardiol on October 23, 2010
The pathogenesis of cardiac fibrosis. Cell Mol Life Sci (2013) 1.96
Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol (2013) 1.70
Heart failure in elderly patients: distinctive features and unresolved issues. Eur J Heart Fail (2013) 1.66
Aging and Cardiac Fibrosis. Aging Dis (2011) 1.58
JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol (2015) 1.51
Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogenesis Tissue Repair (2012) 1.12
Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol (2013) 1.09
Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res (2014) 1.03
Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs. J Mol Cell Cardiol (2014) 1.00
The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis. Kidney Int (2014) 0.97
Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts. J Mol Cell Cardiol (2013) 0.96
SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. PLoS One (2012) 0.96
Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts. J Cardiovasc Transl Res (2012) 0.95
Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells. PLoS One (2011) 0.93
Effect of interleukin 6 deficiency on renal interstitial fibrosis. PLoS One (2012) 0.92
Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels. FASEB J (2013) 0.91
Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction. Hypertension (2015) 0.89
Th1/M1 conversion to th2/m2 responses in models of inflammation lacking cell death stimulates maturation of monocyte precursors to fibroblasts. Front Immunol (2013) 0.87
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction. J Mol Cell Cardiol (2013) 0.86
Cardiac micro-computed tomography imaging of the aging coronary vasculature. Circ Cardiovasc Imaging (2012) 0.86
Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction. Heart Fail Rev (2015) 0.86
Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Drugs (2016) 0.85
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PLoS One (2013) 0.85
Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview. Int J Inflam (2011) 0.84
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure. Circ Heart Fail (2017) 0.84
Classifying aging as a disease in the context of ICD-11. Front Genet (2015) 0.81
Non-sirtuin histone deacetylases in the control of cardiac aging. J Mol Cell Cardiol (2015) 0.81
Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblasts via an IL-6-dependent mechanism in the aging mouse heart. FASEB J (2015) 0.80
Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages. PLoS One (2013) 0.80
Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart. Toxicol Pathol (2012) 0.79
Role of Circulating Fibrocytes in Cardiac Fibrosis. Chin Med J (Engl) (2016) 0.79
Tumor necrosis factor: a mechanistic link between angiotensin-II-induced cardiac inflammation and fibrosis. Circ Heart Fail (2014) 0.79
New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure. J Am Heart Assoc (2017) 0.78
Phosphocholine-containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states. Immun Inflamm Dis (2016) 0.77
Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart. J Mol Cell Cardiol (2015) 0.76
Gualou Xiebai decoction inhibits cardiac dysfunction and inflammation in cardiac fibrosis rats. BMC Complement Altern Med (2016) 0.75
Aicar treatment reduces interstitial fibrosis in aging mice: Suppression of the inflammatory fibroblast. J Mol Cell Cardiol (2017) 0.75
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol (2006) 7.84
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med (2005) 5.13
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature (2000) 3.81
A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J Histochem Cytochem (1994) 3.09
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation (2009) 2.96
Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol (2000) 2.89
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A (2006) 2.85
Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc Biol (2008) 2.30
Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation (2007) 2.14
Loss of cardioprotection with ageing. Cardiovasc Res (2009) 1.94
Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol (2008) 1.90
Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol (2010) 1.73
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proc Natl Acad Sci U S A (2000) 1.68
Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. Basic Res Cardiol (2009) 1.62
Congestive heart failure in the elderly. J Am Geriatr Soc (1991) 1.53
Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.50
Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells. Proc Natl Acad Sci U S A (2008) 1.48
Protective effect of long-term angiotensin II inhibition. Am J Physiol Heart Circ Physiol (2007) 1.44
Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade. J Mol Cell Cardiol (2004) 1.40
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res (2009) 1.38
Cardiac fibrosis as a cause of diastolic dysfunction. Herz (2002) 1.35
Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol (2008) 1.30
Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal (2010) 1.21
Heart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure. Am J Physiol Heart Circ Physiol (2002) 1.20
Myocardial fibrosis in transforming growth factor beta(1)heterozygous mice. J Mol Cell Cardiol (2000) 1.19
Protective effect of the inhibition of the renin-angiotensin system on aging. Regul Pept (2005) 1.16
Th1/Th2 changes in aging. Mech Ageing Dev (1997) 1.15
Age-related changes in Type 1 and Type 2 cytokine production in humans. Biogerontology (2002) 1.15
The age-associated alterations in late diastolic function in mice are improved by caloric restriction. J Gerontol A Biol Sci Med Sci (1997) 1.14
Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. J Gerontol A Biol Sci Med Sci (2006) 1.13
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor. Basic Res Cardiol (2007) 1.08
Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. Exp Gerontol (2007) 1.07
Enhanced calcium uptake of cardiac sarcoplasmic reticulum in exercise-trained old rats. Am J Physiol (1990) 1.05
Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model. Am J Physiol Heart Circ Physiol (2010) 1.04
Contribution of left ventricular diastolic function to exercise capacity in normal subjects. J Appl Physiol (1985) (1993) 1.01
Impaired lusitropy-frequency in the aging mouse: role of Ca(2+)-handling proteins and effects of isoproterenol. Am J Physiol (1999) 0.98
Where are all the women with heart failure? J Am Coll Cardiol (1997) 0.97
Cardiovascular changes by long-term inhibition of the renin-angiotensin system in aging. Hypertension (1995) 0.93
Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats. Circulation (1994) 0.92
Immunosuppression after injury in aged mice is associated with a TH1-TH2 shift, which can be restored by estrogen treatment. Mech Ageing Dev (2004) 0.92
Survival of elderly men with congestive heart failure. Age Ageing (1992) 0.92
Biological aspects of monocyte chemoattractant protein-1 (MCP-1). Adv Exp Med Biol (1991) 0.91
Comparison of one-year outcome (death and rehospitalization) in hospitalized heart failure patients with left ventricular ejection fraction >50% versus those with ejection fraction <50%. Am J Cardiol (2008) 0.90
Diastolic heart failure: a misNOmer. Basic Res Cardiol (2009) 0.88
Alteration of messenger RNA and protein levels of cardiac alpha(1)-adrenergic receptor and angiotensin II receptor subtypes during aging in rats. Can J Cardiol (2009) 0.84
Severe impairment of ventricular compliance accounts for advanced age-associated hemodynamic dysfunction in rats. Exp Gerontol (2006) 0.83
Age-associated decline in IL-4 production by murine T lymphocytes in extended culture. Cell Immunol (1993) 0.82
Comparative effects of dehydroepiandrosterone sulfate on ventricular diastolic function with young and aged female mice. Am J Physiol Regul Integr Comp Physiol (2005) 0.81
Relationship between age, chronic exercise, and connective tissue of the heart. J Gerontol (1972) 0.78
The inflammatory response in myocardial infarction. Cardiovasc Res (2002) 7.92
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res (2005) 4.14
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A (2006) 2.85
Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol (2004) 2.61
Novel approaches to perioperative assessment and intervention may improve long-term outcomes after colorectal cancer resection in older adults. Ann Surg (2011) 2.16
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation (2012) 2.14
Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation (2007) 2.14
Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation (2005) 2.09
Molecular remodelling of dystrophin in patients with end-stage cardiomyopathies and reversal in patients on assistance-device therapy. Lancet (2002) 2.06
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J (2006) 1.99
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85
Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells. Ann N Y Acad Sci (2004) 1.80
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A (2006) 1.76
TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. J Clin Invest (2007) 1.75
Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol (2010) 1.73
Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity. Sci Transl Med (2013) 1.69
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. EMBO J (2004) 1.62
Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. Am J Physiol Regul Integr Comp Physiol (2010) 1.54
The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol (2006) 1.52
Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.50
Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension (2011) 1.49
Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells. Proc Natl Acad Sci U S A (2008) 1.48
Measurement of aortic input impedance in mice: effects of age on aortic stiffness. Am J Physiol Heart Circ Physiol (2003) 1.46
Extracellular matrix remodeling following myocardial injury. Ann Med (2003) 1.41
Morphological characteristics of the microvasculature in healing myocardial infarcts. J Histochem Cytochem (2002) 1.41
Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc (2010) 1.41
Doppler estimation of reduced coronary flow reserve in mice with pressure overload cardiac hypertrophy. Ultrasound Med Biol (2008) 1.40
Trigeminal trophic syndrome. South Med J (2007) 1.40
Mast cells and macrophages in normal C57/BL/6 mice. Histochem Cell Biol (2002) 1.38
Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res (2009) 1.38
Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci U S A (2003) 1.37
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Circulation (2004) 1.35
Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res (2009) 1.34
Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation (2003) 1.33
Coronary microembolization: the role of TNF-alpha in contractile dysfunction. J Mol Cell Cardiol (2002) 1.32
Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy. Proc Natl Acad Sci U S A (2004) 1.29
Effects of isoflurane on coronary blood flow velocity in young, old and ApoE(-/-) mice measured by Doppler ultrasound. Ultrasound Med Biol (2007) 1.29
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol (2006) 1.28
Pulsed Doppler signal processing for use in mice: applications. IEEE Trans Biomed Eng (2005) 1.28
Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol (2006) 1.27
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest (2010) 1.25
CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol (2011) 1.24
Chemokines in myocardial ischemia. Trends Cardiovasc Med (2005) 1.24
Active interstitial remodeling: an important process in the hibernating human myocardium. J Am Coll Cardiol (2002) 1.22
The role of natural IgM in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol (2006) 1.22
Heart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure. Am J Physiol Heart Circ Physiol (2002) 1.20
MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol (2003) 1.20
Evidence for an active inflammatory process in the hibernating human myocardium. Am J Pathol (2002) 1.19
Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation (2003) 1.18
Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart. J Am Heart Assoc (2013) 1.18
Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ Heart Fail (2009) 1.17
Molecular normalization of dystrophin in the failing left and right ventricle of patients treated with either pulsatile or continuous flow-type ventricular assist devices. J Am Coll Cardiol (2004) 1.17
Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction. Cardiovasc Res (2011) 1.15
CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis. Am J Physiol Heart Circ Physiol (2011) 1.14
Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr (2011) 1.14
Critical role of CXCL16 in hypertensive kidney injury and fibrosis. Hypertension (2013) 1.13
Noninvasive cardiovascular phenotyping in mice. ILAR J (2002) 1.12
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. Proc Natl Acad Sci U S A (2002) 1.11
Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart. Circulation (2002) 1.09
Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol (2013) 1.09
Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A (2005) 1.09
TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. J Mol Cell Cardiol (2013) 1.08
Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation (2005) 1.07
Doppler evaluation of peripheral vascular adaptations to transverse aortic banding in mice. Ultrasound Med Biol (2003) 1.06
Determinants of cardiac electrophysiological properties in mice. J Interv Card Electrophysiol (2004) 1.02
Soluble adhesion molecules and the search for biomarkers for atherosclerosis. Circulation (2002) 1.02
CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis. PLoS One (2013) 1.02
Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol (2005) 1.01
Cardiac function in young and old Little mice. J Gerontol A Biol Sci Med Sci (2007) 1.01
Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway. Am J Pathol (2011) 1.00
Effect of age on peripheral vascular response to transverse aortic banding in mice. J Gerontol A Biol Sci Med Sci (2003) 0.99
SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. PLoS One (2012) 0.96
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One (2013) 0.96
Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts. J Cardiovasc Transl Res (2012) 0.95
Evidence of improved right ventricular structure after LVAD support in patients with end-stage cardiomyopathy. J Heart Lung Transplant (2004) 0.93