Published in PLoS Genet on October 21, 2010
Understanding the contribution of synonymous mutations to human disease. Nat Rev Genet (2011) 3.82
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med (2015) 2.43
New population-based exome data are questioning the pathogenicity of previously cardiomyopathy-associated genetic variants. Eur J Hum Genet (2013) 1.80
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J (2011) 1.67
Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum Mol Genet (2012) 1.37
Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. Proc Natl Acad Sci U S A (2011) 1.33
Genetics of sudden cardiac death syndromes. Curr Opin Cardiol (2011) 1.02
Small heat shock proteins in redox metabolism: implications for cardiovascular diseases. Int J Biochem Cell Biol (2012) 0.99
The sarcomeric Z-disc and Z-discopathies. J Biomed Biotechnol (2011) 0.99
The genomic architecture of sporadic heart failure. Circ Res (2011) 0.95
Genome-wide association studies of late-onset cardiovascular disease. J Mol Cell Cardiol (2015) 0.89
Genetics and genomics of dilated cardiomyopathy and systolic heart failure. Genome Med (2017) 0.87
Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. Antioxid Redox Signal (2012) 0.87
Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds. PLoS One (2012) 0.85
Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Dev Biol (2013) 0.85
Functional genomics applied to cardiovascular medicine. Circulation (2011) 0.85
Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (2014) 0.84
Clinical considerations of heritable factors in common heart failure. Circ Cardiovasc Genet (2011) 0.84
Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells. Diabetes (2015) 0.82
A locus on chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers. PLoS One (2011) 0.82
Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish. Dev Biol (2013) 0.81
Microarray analysis of port wine stains before and after pulsed dye laser treatment. Lasers Surg Med (2013) 0.81
TNNT2 gene polymorphisms are associated with susceptibility to idiopathic dilated cardiomyopathy in the Han Chinese population. Biomed Res Int (2013) 0.80
Polymorphism of ZBTB17 gene is associated with idiopathic dilated cardiomyopathy: a case control study in a Han Chinese population. Eur J Med Res (2013) 0.79
HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. J Cell Sci (2016) 0.79
Genetics of Human and Canine Dilated Cardiomyopathy. Int J Genomics (2015) 0.78
Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation. Int J Oncol (2014) 0.77
TNNT2 Gene Polymorphisms are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in Kazak and Han Chinese. Med Sci Monit (2015) 0.76
Non-iterative, regression-based estimation of haplotype associations with censored survival outcomes. Stat Appl Genet Mol Biol (2012) 0.76
Clinical and Genetic Determinants of Cardiomyopathy Risk among Hematopoietic Cell Transplantation Survivors. Biol Blood Marrow Transplant (2016) 0.75
Common variant rs7597774 in ADD2 is associated with dilated cardiomyopathy in Chinese Han population. Int J Clin Exp Med (2015) 0.75
Common Variants for Heart Failure. Curr Genomics (2015) 0.75
Variants of resistin gene and the risk of idiopathic dilated cardiomyopathy in Pakistan. Meta Gene (2016) 0.75
Genetic polymorphisms associated with heart failure: A literature review. J Int Med Res (2016) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Why most published research findings are false. PLoS Med (2005) 41.68
The heat-shock proteins. Annu Rev Genet (1988) 22.28
A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet (2005) 18.98
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science (2006) 15.18
Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res (2007) 13.47
KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen (2005) 7.93
How to interpret a genome-wide association study. JAMA (2008) 7.54
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
WGAViewer: software for genomic annotation of whole genome association studies. Genome Res (2008) 7.15
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med (1999) 5.61
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Brief report: deletion of the dystrophin muscle-promoter region associated with X-linked dilated cardiomyopathy. N Engl J Med (1993) 4.36
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med (2000) 4.30
Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA (2005) 3.89
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (2003) 3.71
A novel X-linked gene, G4.5. is responsible for Barth syndrome. Nat Genet (1996) 3.58
Clinical and genetic issues in familial dilated cardiomyopathy. J Am Coll Cardiol (2005) 3.42
Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science (1998) 3.22
Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation (1989) 2.94
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet (2004) 2.85
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet (2002) 2.67
Desmin mutation responsible for idiopathic dilated cardiomyopathy. Circulation (1999) 2.59
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy. J Am Coll Cardiol (2009) 2.53
Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab (2003) 2.42
Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol (2004) 2.40
X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus. Circulation (1993) 2.30
Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat Med (2009) 2.08
Metavinculin mutations alter actin interaction in dilated cardiomyopathy. Circulation (2002) 1.95
Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy. J Mol Cell Cardiol (2001) 1.92
Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. J Clin Invest (2000) 1.91
Heat shock factor 1 as a coordinator of stress and developmental pathways. Adv Exp Med Biol (2007) 1.84
Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet (2005) 1.80
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation (2005) 1.67
Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet (2006) 1.63
Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. Biochem Biophys Res Commun (2002) 1.55
Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circ Cardiovasc Genet (2010) 1.51
The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. Biochemistry (1999) 1.51
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One (2008) 1.51
[Familial dilated cardiomyopathy]. Herz (2005) 1.42
Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Lancet (2004) 1.38
The X-linked gene G4.5 is responsible for different infantile dilated cardiomyopathies. Am J Hum Genet (1997) 1.37
Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum Mutat (2005) 1.37
Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues. J Biol Chem (1999) 1.26
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. J Am Coll Cardiol (2009) 1.22
Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy. Eur Heart J (2009) 1.19
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. J Clin Invest (2009) 1.10
Characterization of a unique genetic variant in the beta1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy. CARDIGENE Group. J Mol Cell Cardiol (1999) 1.09
HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome Res (2008) 1.00
Common susceptibility variants examined for association with dilated cardiomyopathy. Ann Hum Genet (2010) 0.99
Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy. Hum Genet (2000) 0.99
Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7. Eur J Cell Biol (2007) 0.99
Frequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy. Am J Cardiol (2003) 0.98
A new locus for autosomal dominant dilated cardiomyopathy identified on chromosome 6q12-q16. Am J Hum Genet (2000) 0.96
HSPB7 is a SC35 speckle resident small heat shock protein. Biochim Biophys Acta (2009) 0.95
A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy. Mol Genet Metab (2008) 0.95
Identification of a genetic risk factor for idiopathic dilated cardiomyopathy. Involvement of a polymorphism in the endothelin receptor type A gene. CARDIGENE group. Eur Heart J (1999) 0.90
Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy. Circ J (2008) 0.90
In vivo role of CLC chloride channels in the kidney. Am J Physiol Renal Physiol (2000) 0.89
De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene. Clin Cancer Res (2007) 0.88
The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. Mol Cell Biochem (2006) 0.77
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med (2008) 43.36
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med (2007) 18.78
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron (2004) 14.35
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J (2013) 12.73
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10