Published in Nat Commun on October 19, 2010
Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Cell (2011) 2.86
How cells get the message: dynamic assembly and function of mRNA-protein complexes. Nat Rev Genet (2013) 1.67
Influenza Virus mRNA Trafficking Through Host Nuclear Speckles. Nat Microbiol (2016) 1.41
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion. Nat Commun (2012) 1.35
Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes Dev (2015) 1.31
Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci U S A (2011) 1.13
Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export. Nucleic Acids Res (2012) 1.12
Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. RNA (2013) 1.08
Chtop is a component of the dynamic TREX mRNA export complex. EMBO J (2013) 1.07
Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res (2012) 1.06
The case for junk DNA. PLoS Genet (2014) 1.00
To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta (2012) 0.98
Viral factors reveal a role for REF/Aly in nuclear RNA stability. Mol Cell Biol (2012) 0.97
Perispeckles are major assembly sites for the exon junction core complex. Mol Biol Cell (2012) 0.95
The role of nuclear bodies in gene expression and disease. Biology (Basel) (2013) 0.91
The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS One (2012) 0.86
The RNA helicase DDX5/p68 is a key factor promoting c-fos expression at different levels from transcription to mRNA export. Nucleic Acids Res (2012) 0.86
Btf and TRAP150 have distinct roles in regulating subcellular mRNA distribution. Nucleus (2013) 0.85
A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18. Nucleic Acids Res (2014) 0.85
Intellectual disability associated with a homozygous missense mutation in THOC6. Orphanet J Rare Dis (2013) 0.85
Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis (2013) 0.85
Trafficking of mRNAs containing ALREX-promoting elements through nuclear speckles. Nucleus (2013) 0.84
An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway. PLoS One (2011) 0.82
Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization. J Virol (2015) 0.82
HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis. PLoS Genet (2015) 0.82
Integrating many co-splicing networks to reconstruct splicing regulatory modules. BMC Syst Biol (2012) 0.80
Pre-mRNA Splicing in Plants: In Vivo Functions of RNA-Binding Proteins Implicated in the Splicing Process. Biomolecules (2015) 0.80
Mapping interactions between mRNA export factors in living cells. PLoS One (2013) 0.80
The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. J Mol Cell Biol (2014) 0.79
The role of TREX in gene expression and disease. Biochem J (2016) 0.79
THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation. Cell Commun Signal (2014) 0.78
The consensus 5' splice site motif inhibits mRNA nuclear export. PLoS One (2015) 0.78
Co-transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae. Bioessays (2015) 0.77
Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation. J Biol Chem (2015) 0.77
Tracking intron removal in real time. Dev Cell (2011) 0.77
Alternative splicing acting as a bridge in evolution. Stem Cell Investig (2015) 0.76
Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus. PLoS One (2014) 0.76
UAP56 is a conserved crucial component of a divergent mRNA export pathway in Toxoplasma gondii. Mol Microbiol (2016) 0.75
Sumoylation is Required for the Cytoplasmic Accumulation of a Subset of mRNAs. Genes (Basel) (2014) 0.75
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening. PLoS Genet (2016) 0.75
Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner. Cell Discov (2015) 0.75
Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells. Genet Res Int (2011) 0.75
An extensive network of coupling among gene expression machines. Nature (2002) 11.84
Pre-mRNA processing reaches back to transcription and ahead to translation. Cell (2009) 7.45
Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol (2003) 6.98
Regulating gene expression through RNA nuclear retention. Cell (2005) 5.58
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature (2000) 5.57
Higher level organization of individual gene transcription and RNA splicing. Science (1993) 4.50
Protein dynamics: implications for nuclear architecture and gene expression. Science (2001) 4.38
Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31
Splicing is required for rapid and efficient mRNA export in metazoans. Proc Natl Acad Sci U S A (1999) 4.26
Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol (2007) 4.12
Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol (2007) 3.97
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature (2001) 3.94
A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell (2002) 3.88
Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus. J Cell Biol (1991) 3.48
Human mRNA export machinery recruited to the 5' end of mRNA. Cell (2006) 3.32
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. J Cell Biol (2008) 3.13
Recruitment of the human TREX complex to mRNA during splicing. Genes Dev (2005) 3.13
REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc Natl Acad Sci U S A (2001) 3.10
SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell (2009) 2.73
U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev (1997) 2.67
Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains. J Cell Biol (1995) 2.61
THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association. Cell (2008) 2.58
Coupling transcription, splicing and mRNA export. Curr Opin Cell Biol (2003) 2.54
In vivo analysis of the stability and transport of nuclear poly(A)+ RNA. J Cell Biol (1994) 2.52
Inefficient processing impairs release of RNA from the site of transcription. EMBO J (1999) 2.50
Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol (2008) 2.38
Molecular anatomy of a speckle. Anat Rec A Discov Mol Cell Evol Biol (2006) 2.37
Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific. J Cell Biol (1999) 2.24
Nuclear neighborhoods and gene expression. Curr Opin Genet Dev (2009) 2.21
TREX, SR proteins and export of mRNA. Curr Opin Cell Biol (2005) 2.19
Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels. RNA (1999) 2.06
Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.98
Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production. J Cell Biol (2008) 1.98
mRNA nuclear export at a glance. J Cell Sci (2009) 1.85
Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells. J Cell Biol (2004) 1.74
Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain. J Cell Biol (2000) 1.74
Intranuclear distribution of poly(A) RNA determined by electron microscope in situ hybridization. Exp Cell Res (1993) 1.68
The exosome and RNA quality control in the nucleus. EMBO Rep (2007) 1.64
Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev (2008) 1.62
Early formation of mRNP: license for export or quality control? Mol Cell (2003) 1.58
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res (2008) 1.57
UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Curr Biol (2009) 1.45
Identity elements used in export of mRNAs. Mol Cell (2002) 1.37
Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs. Mol Biol Cell (2000) 1.31
Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore. Curr Opin Cell Biol (2005) 1.31
Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. Gene (2006) 1.26
Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev (2008) 1.25
Gene associations: true romance or chance meeting in a nuclear neighborhood? J Cell Biol (2008) 1.23
Formation of export-competent mRNP: escaping nuclear destruction. Curr Opin Cell Biol (2005) 1.18
Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains. J Cell Biol (2007) 1.16
Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells: nuclear mRNA export is coupled to ongoing gene transcription. Genes Cells (2006) 1.10
Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci U S A (2008) 1.08
Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains. J Struct Biol (2002) 1.08
Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci. Cell Cycle (2009) 1.00
Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles. Mol Biol Cell (2001) 0.98
The dynamics of pre-mRNAs and poly(A)+ RNA at speckles in living cells revealed by iFRAP studies. Exp Cell Res (2007) 0.86
mRNA journey to the cytoplasm: attire required. Biol Cell (2008) 0.86
Induction of p21 mRNA synthesis after short-wavelength UV light visualized in individual cells by RNA FISH. J Histochem Cytochem (2002) 0.84
A link between transcription and mRNP quality in Saccharomyces cerevisiae. RNA Biol (2005) 0.83
[Single-molecule imaging and quantification of mRNAs in a living cell]. Yakugaku Zasshi (2009) 0.77
An extensive network of coupling among gene expression machines. Nature (2002) 11.84
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med (2011) 11.07
Comprehensive proteomic analysis of the human spliceosome. Nature (2002) 6.85
TREX is a conserved complex coupling transcription with messenger RNA export. Nature (2002) 6.53
Human mRNA export machinery recruited to the 5' end of mRNA. Cell (2006) 3.32
Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery. Cell (2004) 3.16
Recruitment of the human TREX complex to mRNA during splicing. Genes Dev (2005) 3.13
SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Mol Cell (2007) 3.04
Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.98
Functional coupling of RNAP II transcription to spliceosome assembly. Genes Dev (2006) 1.98
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proc Natl Acad Sci U S A (2004) 1.97
Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A (2005) 1.83
Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. Proc Natl Acad Sci U S A (2004) 1.70
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA. Blood (2007) 1.69
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev (2011) 1.64
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res (2008) 1.57
Purification and electron microscopic visualization of functional human spliceosomes. Proc Natl Acad Sci U S A (2002) 1.52
FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Rep (2012) 1.50
Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis (2008) 1.45
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev (2010) 1.38
Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci (2013) 1.31
TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export. Nat Commun (2012) 1.30
Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med (Berl) (2007) 1.17
Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein. Protein Expr Purif (2003) 1.13
Dual luciferase assay system for rapid assessment of gene expression in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.13
Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci U S A (2011) 1.13
Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export. Nucleic Acids Res (2012) 1.12
Purification of functional RNA-protein complexes using MS2-MBP. Curr Protoc Mol Biol (2003) 1.02
A model in vitro system for co-transcriptional splicing. Nucleic Acids Res (2010) 0.94
Phenotypic consequences of branch point substitutions. Hum Mutat (2006) 0.93
Weak definition of IKBKAP exon 20 leads to aberrant splicing in familial dysautonomia. Hum Mutat (2007) 0.93
Small-scale nuclear extracts for functional assays of gene-expression machineries. J Vis Exp (2012) 0.92
Crooked neck is a component of the human spliceosome and implicated in the splicing process. Biochim Biophys Acta (2002) 0.91
The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS One (2012) 0.86
Lack of association of the -1171 (5A) allele of the MMP3 promoter with breast cancer. Clin Chem (2002) 0.83
No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22. Int J Cancer (2002) 0.83
A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. J Med Genet (2013) 0.82
Identification of RNA binding proteins by UV cross-linking. Curr Protoc Mol Biol (2003) 0.80
BACH1 517C-->T transition impairs protein translocation to nucleus: a role in breast cancer susceptibility? Int J Cancer (2003) 0.80
In vitro systems for coupling RNAP II transcription to splicing and polyadenylation. Methods Mol Biol (2014) 0.79
Re: Dominant negative ATM mutations in breast cancer families. J Natl Cancer Inst (2002) 0.77
Single nucleotide polymorphisms in the DMBT1 promoter and the progression of breast cancer. Int J Cancer (2007) 0.76
Agarose gel separation/isolation of RNA-protein complexes. Curr Protoc Mol Biol (2003) 0.76
Mental illness recognition and referral by Catholic priests in North Carolina. Psychiatr Serv (2012) 0.75