Fitness correlates of heritable variation in antibody responsiveness in a wild mammal.

PubWeight™: 2.48‹?› | Rank: Top 2%

🔗 View Article (PMID 21030656)

Published in Science on October 29, 2010

Authors

Andrea L Graham1, Adam D Hayward, Kathryn A Watt, Jill G Pilkington, Josephine M Pemberton, Daniel H Nussey

Author Affiliations

1: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. algraham@princeton.edu

Articles citing this

Diversity and dialogue in immunity to helminths. Nat Rev Immunol (2011) 3.72

Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol (2011) 1.90

Neonatal body condition, immune responsiveness, and hematocrit predict longevity in a wild bird population. Ecology (2014) 1.20

The costs of evolving resistance in heterogeneous parasite environments. Proc Biol Sci (2011) 1.19

The impact of multiple infections on wild animal hosts: a review. Infect Ecol Epidemiol (2011) 1.17

Deciphering serology to understand the ecology of infectious diseases in wildlife. Ecohealth (2013) 1.12

Experimental elimination of parasites in nature leads to the evolution of increased resistance in hosts. Proc Biol Sci (2013) 1.07

Maternal antibody persistence: a neglected life-history trait with implications from albatross conservation to comparative immunology. Proc Biol Sci (2011) 1.02

Multivariate immune defences and fitness in the wild: complex but ecologically important associations among plasma antibodies, health and survival. Proc Biol Sci (2014) 1.02

Why infectious disease research needs community ecology. Science (2015) 1.00

The domestic dog: man's best friend in the genomic era. Genome Biol (2011) 1.00

Natural selection on individual variation in tolerance of gastrointestinal nematode infection. PLoS Biol (2014) 0.99

Age-related variation in immunity in a wild mammal population. Aging Cell (2011) 0.97

How does variability of immune system genes affect placentation? Placenta (2011) 0.96

The molecular pathways underlying host resistance and tolerance to pathogens. Front Genet (2012) 0.95

Immune regulation during helminth infections. PLoS Pathog (2013) 0.95

Is there sex-biased resistance and tolerance in Mediterranean wood mouse (Apodemus sylvaticus) populations facing multiple helminth infections? Oecologia (2012) 0.94

Into the wild: digging at immunology's evolutionary roots. Nat Immunol (2013) 0.94

Schistosome infection intensity is inversely related to auto-reactive antibody levels. PLoS One (2011) 0.94

Harnessing evolutionary biology to combat infectious disease. Nat Med (2012) 0.92

Pathogen evolution and the immunological niche. Ann N Y Acad Sci (2014) 0.85

Integrating evolution in the management of captive zoo populations. Evol Appl (2015) 0.85

Immune phenotype and body condition in roe deer: individuals with high body condition have different, not stronger immunity. PLoS One (2012) 0.84

Costs of reproduction in a long-lived female primate: injury risk and wound healing. Behav Ecol Sociobiol (2014) 0.84

Are Human Intestinal Eukaryotes Beneficial or Commensals? PLoS Pathog (2015) 0.83

Ecoimmunology for psychoneuroimmunologists: Considering context in neuroendocrine-immune-behavior interactions. Brain Behav Immun (2014) 0.83

Applying evolutionary concepts to wildlife disease ecology and management. Evol Appl (2014) 0.82

No selection on immunological markers in response to a highly virulent pathogen in an Arctic breeding bird. Evol Appl (2014) 0.82

Immune profile predicts survival and reflects senescence in a small, long-lived mammal, the greater sac-winged bat (Saccopteryx bilineata). PLoS One (2014) 0.81

Immune activity, body condition and human-associated environmental impacts in a wild marine mammal. PLoS One (2013) 0.81

Helminths and the microbiota: parts of the hygiene hypothesis. Parasite Immunol (2015) 0.81

Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution. Immunogenetics (2016) 0.80

Evolutionary trajectories explain the diversified evolution of isogamy and anisogamy in marine green algae. Proc Natl Acad Sci U S A (2012) 0.80

Markedly Elevated Antibody Responses in Wild versus Captive Spotted Hyenas Show that Environmental and Ecological Factors Are Important Modulators of Immunity. PLoS One (2015) 0.79

The cost of phage resistance in a plant pathogenic bacterium is context-dependent. Evolution (2015) 0.79

Life-history strategy defends against disease and may select against physiological resistance. Ecol Evol (2013) 0.79

Eggshell spottiness reflects maternally transferred antibodies in blue tits. PLoS One (2012) 0.79

Associations between innate immune function and ectoparasites in wild rodent hosts. Parasitol Res (2013) 0.78

Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply. J R Soc Interface (2012) 0.77

Opportunities and challenges of Integral Projection Models for modelling host-parasite dynamics. J Anim Ecol (2015) 0.77

Genetic and phenotypic selection affect natural (auto-) antibody reactivity of chickens. PLoS One (2013) 0.77

Oxidant trade-offs in immunity: an experimental test in a lizard. PLoS One (2015) 0.76

Beyond mice and men: environmental change, immunity and infections in wild ungulates. Parasite Immunol (2015) 0.76

Activation of an inflammatory response is context-dependent during early development of the California sea lion. R Soc Open Sci (2015) 0.76

Eco-immunology and bioinvasion: revisiting the evolution of increased competitive ability hypotheses. Evol Appl (2016) 0.75

Age-specific haemosporidian infection dynamics and survival in Seychelles warblers. Sci Rep (2016) 0.75

Socioecological predictors of immune defences in wild spotted hyenas. Funct Ecol (2016) 0.75

Investment in constitutive immune function by North American elk experimentally maintained at two different population densities. PLoS One (2015) 0.75

The cost of living longer. Fertility trades with immunity and life expectancy. EMBO Rep (2011) 0.75

Disrupting immune regulation incurs transient costs in male reproductive function. PLoS One (2014) 0.75

Immunology. Infection protection and natural selection. Science (2010) 0.75

Testosterone and cortisol concentrations vary with reproductive status in wild female red deer. Ecol Evol (2016) 0.75

Age, but not anthelmintic treatment, is associated with urinary neopterin levels in semi-free ranging Barbary macaques. Sci Rep (2017) 0.75

Mechanisms and consequences of diversity-generating immune strategies. Nat Rev Immunol (2017) 0.75

Robust extraction of quantitative structural information from high-variance histological images of livers from necropsied Soay sheep. R Soc Open Sci (2017) 0.75

Physiological proteins in resource-limited herbivores experiencing a population die-off. Naturwissenschaften (2017) 0.75

Negative impact of urban habitat on immunity in the great tit Parus major. Oecologia (2016) 0.75

Articles by these authors

An ecologist's guide to the animal model. J Anim Ecol (2010) 2.91

Sexually antagonistic genetic variation for fitness in red deer. Nature (2007) 2.78

Inbreeding avoidance, tolerance, or preference in animals? Trends Ecol Evol (2012) 2.56

Antler size in red deer: heritability and selection but no evolution. Evolution (2002) 2.25

Revealing the history of sheep domestication using retrovirus integrations. Science (2009) 2.12

Performance of marker-based relatedness estimators in natural populations of outbred vertebrates. Genetics (2006) 2.00

The dynamics of phenotypic change and the shrinking sheep of St. Kilda. Science (2009) 1.99

What is individual quality? An evolutionary perspective. Trends Ecol Evol (2009) 1.86

The rate of senescence in maternal performance increases with early-life fecundity in red deer. Ecol Lett (2006) 1.59

Genome-wide association mapping identifies the genetic basis of discrete and quantitative variation in sexual weaponry in a wild sheep population. Mol Ecol (2011) 1.58

Oxidative damage, ageing, and life-history evolution: where now? Trends Ecol Evol (2012) 1.55

Life history trade-offs at a single locus maintain sexually selected genetic variation. Nature (2013) 1.52

Live fast, die young: trade-offs between fitness components and sexually antagonistic selection on weaponry in Soay sheep. Evolution (2006) 1.51

Environmental conditions in early life influence ageing rates in a wild population of red deer. Curr Biol (2007) 1.49

Selection on mothers and offspring: whose phenotype is it and does it matter? Evolution (2005) 1.45

Evidence for evolution in response to natural selection in a contemporary human population. Proc Natl Acad Sci U S A (2011) 1.31

Linkage mapping reveals sex-dimorphic map distances in a passerine bird. Proc Biol Sci (2005) 1.29

Gene mapping in the wild with SNPs: guidelines and future directions. Genetica (2008) 1.27

Gene order and recombination rate in homologous chromosome regions of the chicken and a passerine bird. Mol Biol Evol (2007) 1.25

Plastic parasites: sophisticated strategies for survival and reproduction? Evol Appl (2009) 1.24

Inbreeding depression in red deer calves. BMC Evol Biol (2011) 1.24

Estimating quantitative genetic parameters in wild populations: a comparison of pedigree and genomic approaches. Mol Ecol (2014) 1.18

Comparing parentage inference software: reanalysis of a red deer pedigree. Mol Ecol (2010) 1.14

Patterns of body mass senescence and selective disappearance differ among three species of free-living ungulates. Ecology (2011) 1.14

Inter- and intrasexual variation in aging patterns across reproductive traits in a wild red deer population. Am Nat (2009) 1.13

Age-related variation in reproductive traits in the wandering albatross: evidence for terminal improvement following senescence. Ecol Lett (2013) 1.13

Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries). Genetics (2006) 1.11

Evidence for a genetic basis of aging in two wild vertebrate populations. Curr Biol (2007) 1.10

Introgression and the fate of domesticated genes in a wild mammal population. Mol Ecol (2013) 1.09

Inbreeding and inbreeding depression of early life traits in a cooperative mammal. Mol Ecol (2012) 1.09

Shared spatial effects on quantitative genetic parameters: accounting for spatial autocorrelation and home range overlap reduces estimates of heritability in wild red deer. Evolution (2012) 1.07

Mapping quantitative trait Loci underlying fitness-related traits in a free-living sheep population. Evolution (2007) 1.02

Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep (Ovis aries). Int J Parasitol (2006) 1.02

Multivariate immune defences and fitness in the wild: complex but ecologically important associations among plasma antibodies, health and survival. Proc Biol Sci (2014) 1.02

The impact of environmental heterogeneity on genetic architecture in a wild population of Soay sheep. Genetics (2009) 1.00

The prediction of adaptive evolution: empirical application of the secondary theorem of selection and comparison to the breeder's equation. Evolution (2012) 0.98

Age-related variation in immunity in a wild mammal population. Aging Cell (2011) 0.97

Environmental heterogeneity generates fluctuating selection on a secondary sexual trait. Curr Biol (2008) 0.97

Into the wild: digging at immunology's evolutionary roots. Nat Immunol (2013) 0.94

Genetic analysis of life-history constraint and evolution in a wild ungulate population. Am Nat (2012) 0.93

Relationship between susceptibility of Blackface sheep to Teladorsagia circumcincta infection and an inflammatory mucosal T cell response. Vet Res (2012) 0.92

The problem of auto-correlation in parasitology. PLoS Pathog (2012) 0.92

Distribution of a naturally fluctuating ungulate population among heterogeneous plant communities: ideal and free? J Anim Ecol (2006) 0.92

Variable extent of hybridization between invasive sika (Cervus nippon) and native red deer (C. elaphus) in a small geographical area. Mol Ecol (2009) 0.91

Ageing in a variable habitat: environmental stress affects senescence in parasite resistance in St Kilda Soay sheep. Proc Biol Sci (2009) 0.90

Modeling linkage disequilibrium in natural populations: the example of the Soay sheep population of St. Kilda, Scotland. Genetics (2005) 0.89

Sexual conflict in twins: male co-twins reduce fitness of female Soay sheep. Biol Lett (2009) 0.87

Predictors of early survival in Soay sheep: cohort-, maternal- and individual-level variation. Proc Biol Sci (2005) 0.86

Heritable, heterogeneous, and costly resistance of sheep against nematodes and potential feedbacks to epidemiological dynamics. Am Nat (2014) 0.86

Identifying when weather influences life-history traits of grazing herbivores. J Anim Ecol (2007) 0.85

Heterogeneity of genetic architecture of body size traits in a free-living population. Mol Ecol (2015) 0.84

The population growth consequences of variation in individual heterozygosity. PLoS One (2011) 0.83

Variances and covariances of phenological traits in a wild mammal population. Evolution (2010) 0.83

Ageing: it's a dog's life. Curr Biol (2013) 0.83

Testes size, testosterone production and reproductive behaviour in a natural mammalian mating system. J Anim Ecol (2011) 0.81

Individual differences, density dependence and offspring birth traits in a population of red deer. Proc Biol Sci (2008) 0.79

Phenotypic correlates of hybridisation between red and sika deer (genus Cervus). J Anim Ecol (2009) 0.78

Getting the timing right: antler growth phenology and sexual selection in a wild red deer population. Oecologia (2010) 0.76

Recombination and inbreeding strategy in sexually reproducing animals: a reply to Cherry. Trends Ecol Evol (2013) 0.75

The effect of socio-economic status and food availability on first birth interval in a pre-industrial human population. Proc Biol Sci (2013) 0.75

The impact of past introductions on an iconic and economically important species, the red deer of Scotland. J Hered (2012) 0.75