Published in Am J Pathol on October 29, 2010
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice. J Thromb Haemost (2014) 1.54
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects. Fibrogenesis Tissue Repair (2013) 1.27
Integrin-mediated regulation of TGFβ in fibrosis. Biochim Biophys Acta (2012) 1.12
Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J (2012) 0.92
TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res (2012) 0.87
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism. Blood (2016) 0.87
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury. Toxicol Sci (2010) 0.87
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J Pharmacol Exp Ther (2014) 0.87
Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells. J Pharmacol Exp Ther (2011) 0.85
αVβ6 integrin promotes corneal wound healing. Invest Ophthalmol Vis Sci (2011) 0.82
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice. Toxicol Sci (2011) 0.81
Role of hemostatic factors in hepatic injury and disease: animal models de-liver. J Thromb Haemost (2016) 0.80
Autocrine regulation of biliary pathology by activated cholangiocytes. Am J Physiol Gastrointest Liver Physiol (2011) 0.79
Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis. Eur J Histochem (2013) 0.79
Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers. Onco Targets Ther (2015) 0.78
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis. J Biochem Mol Toxicol (2016) 0.77
Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells. J Gastroenterol Hepatol (2012) 0.77
Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. J Hepatol (2015) 0.77
Coagulation in liver toxicity and disease: role of hepatocyte tissue factor. Thromb Res (2014) 0.77
Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression. J Biol Chem (2016) 0.77
Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association? Semin Thromb Hemost (2016) 0.76
Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J (2016) 0.76
Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development. J Clin Transl Hepatol (2015) 0.76
Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin-mediated TGF-β activation. Pharmacol Res Perspect (2014) 0.75
From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis. Toxicol Sci (2016) 0.75
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis. Toxicology (2016) 0.75
Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice. Toxicol Sci (2014) 0.75
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease. Toxicology (2016) 0.75
Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats. Sci Rep (2017) 0.75
Inhibition of viral replication by small interfering RNA targeting of the foot-and-mouth disease virus receptor integrin β6. Exp Ther Med (2017) 0.75
Von Willebrand factor deficiency reduces liver fibrosis in mice. Toxicol Appl Pharmacol (2017) 0.75
Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis. JCI Insight (2017) 0.75
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell (1999) 11.59
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med (2006) 3.84
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol (2005) 2.41
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest (2006) 2.40
CCR2 promotes hepatic fibrosis in mice. Hepatology (2009) 2.35
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
Bile-acid-induced cell injury and protection. World J Gastroenterol (2009) 2.06
Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology (2010) 1.97
Ligand cross-reactivity within the protease-activated receptor family. J Biol Chem (1996) 1.86
Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology (2007) 1.80
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res (2008) 1.73
Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem (2004) 1.72
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology (2008) 1.69
Early growth response factor-1 is critical for cholestatic liver injury. Toxicol Sci (2006) 1.51
The many faces of tissue factor. J Thromb Haemost (2009) 1.48
PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation. Hepatology (2004) 1.42
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis. Am J Physiol Gastrointest Liver Physiol (2001) 1.36
Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol (2001) 1.32
Cholangiocyte proliferation and liver fibrosis. Expert Rev Mol Med (2009) 1.32
Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J Pathol (2009) 1.25
Role of MRP2 and GSH in intrahepatic cycling of toxins. Toxicology (2001) 1.22
Intrahepatic cholestasis induced by drugs and chemicals. Pharmacol Rev (1976) 1.21
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Am J Physiol Gastrointest Liver Physiol (2009) 1.07
Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury. Am J Physiol Gastrointest Liver Physiol (2004) 1.06
Progressive development of a Th1-type hepatic cytokine profile in rats with experimental cholangitis. Hepatology (2000) 1.05
ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am J Physiol Gastrointest Liver Physiol (2006) 1.03
Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease. Am J Pathol (2008) 1.01
Coagulation and fibrinolysis in primary biliary cirrhosis compared with other liver disease and during orthotopic liver transplantation. Hepatology (1997) 1.00
Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT. Transplantation (2004) 1.00
A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat. Pharmacol Res (2005) 0.98
The nature of alpha-naphthylisothiocyanate-induced cholestasis. Toxicol Appl Pharmacol (1965) 0.96
Thrombin stimulates the expression of PDGF in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2000) 0.94
Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers. J Pharmacol Exp Ther (2003) 0.93
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia. Liver Int (2006) 0.90
Neutrophil- and glutathione-mediated hepatotoxicity of alpha-naphthylisothiocyanate. Drug Metab Rev (1997) 0.88
Expression of isoforms and splice variants of the latent transforming growth factor beta binding protein (LTBP) in cultured human liver myofibroblasts. Liver (2001) 0.86
Role of thrombin receptors in the kidney: lessons from PAR1 knock-out mice. Nephrol Dial Transplant (2001) 0.83
Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis. World J Gastroenterol (2006) 0.80
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1. Gastroenterology (2006) 3.53
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology (2007) 1.80
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol (2007) 1.79
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J Cell Sci (2009) 1.75
Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res (2008) 1.73
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res (2008) 1.73
Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem (2004) 1.72
Stromal features are predictive of disease mortality in oral cancer patients. J Pathol (2011) 1.54
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest (2012) 1.51
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol (2009) 1.50
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J Pharmacol Exp Ther (2011) 1.49
Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chem Biol Interact (2004) 1.49
Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6. Mol Cell Biol (2007) 1.41
Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther (2008) 1.36
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology (2007) 1.23
Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice. Hepatology (2009) 1.23
Blockade of Nogo receptor ligands promotes functional regeneration of sensory axons after dorsal root crush. J Neurosci (2009) 1.20
The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle. J Gen Virol (2005) 1.20
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem (2007) 1.18
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med (2007) 1.16
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther (2005) 1.15
Metformin prevents endotoxin-induced liver injury after partial hepatectomy. J Pharmacol Exp Ther (2005) 1.12
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models. Pharmacol Rev (2009) 1.12
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury. Toxicol Sci (2007) 1.09
PAR-1 contributes to the innate immune response during viral infection. J Clin Invest (2013) 1.09
Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler Thromb Vasc Biol (2008) 1.08
Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo. Cancer Res (2003) 1.07
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. J Pharmacol Exp Ther (2006) 1.07
Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther (2008) 1.07
Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol (2008) 1.07
Inflammation and drug idiosyncrasy--is there a connection? J Pharmacol Exp Ther (2003) 1.05
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β. Am J Pathol (2012) 1.03
Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. Lab Invest (2010) 1.02
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med (2009) 1.01
Overexpression of the alphavbeta6 integrin in endometrial cancer. Appl Immunohistochem Mol Morphol (2008) 1.01
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res (2006) 1.01
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol (2010) 1.00
Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma (2010) 1.00
Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci (2005) 0.99
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression. Mol Immunol (2009) 0.99
Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. Toxicol Appl Pharmacol (2013) 0.99
Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res (2014) 0.97
Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity. Toxicol Lett (2004) 0.97
Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol (2011) 0.96
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. Cancer Res (2006) 0.95
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies. Toxicol Sci (2010) 0.94
Characterization of trisulfide modification in antibodies. Anal Biochem (2010) 0.93
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Ther (2007) 0.93
Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy. J Proteome Res (2007) 0.91
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example. Int J Mol Sci (2010) 0.91
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. Am J Pathol (2012) 0.90
Hepatocyte tissue factor activates the coagulation cascade in mice. Blood (2013) 0.90
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity. J Pharmacol Exp Ther (2011) 0.90
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. Am J Pathol (2012) 0.89
Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment. J Mol Biol (2003) 0.89
Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol (2011) 0.87
Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa. Infect Immun (2008) 0.87
α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. Am J Transl Res (2012) 0.87
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J Pharmacol Exp Ther (2014) 0.87
Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice. Hepatology (2015) 0.86
IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol (2013) 0.86
Mechanisms of STAT3 activation in the liver of FXR knockout mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells. J Pharmacol Exp Ther (2011) 0.85
Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2014) 0.83
Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc (2011) 0.83
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice. Toxicol Sci (2011) 0.81
Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4. Am J Cardiol (2010) 0.80
Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology (2014) 0.79
Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide. Toxicol Appl Pharmacol (2005) 0.78
Steatosis DeLIVERs high-sensitivity C-reactive protein. Arterioscler Thromb Vasc Biol (2011) 0.77
Lipopolysaccharide enhances transforming growth factor β1-induced platelet-derived growth factor-B expression in bile duct epithelial cells. J Gastroenterol Hepatol (2012) 0.77
Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function. J Pathol (2014) 0.76
A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions. Anal Biochem (2002) 0.76