Published in Int J Rheumatol on October 16, 2011
Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer. Clin Transl Med (2014) 0.99
Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease. PLoS One (2013) 0.95
Mechanisms of alveolar epithelial injury, repair, and fibrosis. Ann Am Thorac Soc (2015) 0.91
Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis. PLoS One (2013) 0.91
Targeted therapies for systemic sclerosis. Nat Rev Rheumatol (2013) 0.82
Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis. Eur J Histochem (2013) 0.79
The heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion properties. PLoS One (2013) 0.79
Promising new treatment targets in patients with fibrosing lung disorders. World J Clin Cases (2014) 0.75
Integrins as Therapeutic Targets: Successes and Cancers. Cancers (Basel) (2017) 0.75
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell (1999) 11.59
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82
Making sense of latent TGFbeta activation. J Cell Sci (2003) 8.90
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A (2006) 7.08
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol (2007) 5.24
Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis (2007) 4.88
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature (2003) 4.02
Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med (2001) 4.01
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol (2010) 3.57
Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet (1996) 3.52
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci U S A (2000) 3.47
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Nat Genet (1996) 3.42
Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.37
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol (1996) 3.18
Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med (2002) 3.06
Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum (2000) 3.02
High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J (2006) 2.94
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol (2004) 2.90
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83
Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum (2007) 2.80
Molecular subsets in the gene expression signatures of scleroderma skin. PLoS One (2008) 2.66
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol (1997) 2.46
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest (2006) 2.40
Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc (2006) 2.30
Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol (2001) 2.25
Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. J Histochem Cytochem (1993) 2.22
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.15
Gastrointestinal motility disorders in scleroderma. Arthritis Rheum (1994) 2.04
New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest (1989) 2.00
Gastro-oesophageal reflux and interstitial lung disease. Dig Liver Dis (2006) 1.85
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett (2002) 1.64
Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. Thorax (1999) 1.62
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. J Invest Dermatol (2009) 1.60
Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest (2010) 1.54
The pathogenesis of systemic sclerosis. Annu Rev Pathol (2011) 1.54
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum (2007) 1.51
Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains. J Biol Chem (1996) 1.47
Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol (1995) 1.38
Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease. Respir Med (2007) 1.37
Keratinocytes in human wounds express alpha v beta 6 integrin. J Invest Dermatol (1996) 1.32
Does chronic microaspiration cause idiopathic pulmonary fibrosis? Am J Med (2010) 1.30
Clearance of inhaled 99mTc-DTPA predicts the clinical course of fibrosing alveolitis. Eur Respir J (1993) 1.29
Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev (2003) 1.29
Characterization of the innate immune response to chronic aspiration in a novel rodent model. Respir Res (2007) 1.22
The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis (2002) 1.11
Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Arthritis Rheum (1994) 1.10
Scar wars: is TGFbeta the phantom menace in scleroderma? Arthritis Res Ther (2006) 1.05
Non-specific interstitial pneumonia as pulmonary involvement of systemic sclerosis. Ann Rheum Dis (2001) 1.04
Idiopathic pulmonary fibrosis: how often is it really idiopathic? J Gastrointest Surg (2005) 1.03
Gastrointestinal manifestations of systemic sclerosis. Semin Arthritis Rheum (1994) 1.02
Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma. J Dermatol Sci (1999) 0.99
Interstitial lung disease in scleroderma. Rheum Dis Clin North Am (2003) 0.98
Gastroesophageal reflux incites interstitial lung disease in systemic sclerosis: clinical, radiologic, histopathologic, and treatment evidence. Semin Arthritis Rheum (2010) 0.97
Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis. J Invest Dermatol (2010) 0.96
Gastric involvement in systemic sclerosis: a prospective study. Am J Gastroenterol (2001) 0.84
Pathogenesis of pulmonary fibrosis in systemic sclerosis: lessons from interstitial lung disease. Curr Rheumatol Rep (2010) 0.81
The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med (2003) 7.94
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A (2006) 7.08
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 4.94
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med (2002) 4.87
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med (2002) 4.65
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol (2002) 4.60
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature (2003) 4.02
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A (2002) 4.00
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35
Population stratification confounds genetic association studies among Latinos. Hum Genet (2005) 3.19
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol (2005) 3.03
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med (2013) 2.72
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest (2005) 2.61
Retracted Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity (2006) 2.49
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med (2012) 2.47
Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med (2004) 2.42
Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell (2009) 2.41
Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest (2006) 2.40
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17
Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol (2003) 2.05
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 2.03
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A (2007) 1.97
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.91
Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem (2003) 1.90
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem (2005) 1.86
The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem (2002) 1.81
Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology (2007) 1.80
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol (2007) 1.79
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med (2002) 1.76
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J Cell Sci (2009) 1.75
Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res (2008) 1.73
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest (2007) 1.73
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res (2008) 1.73
Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem (2004) 1.72
The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem (2004) 1.69
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest (2009) 1.68
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med (2012) 1.64
TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest (2010) 1.63
Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol (2011) 1.60
Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol (2002) 1.60
Stromal features are predictive of disease mortality in oral cancer patients. J Pathol (2011) 1.54
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell (2005) 1.53
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood (2009) 1.53
Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol (2009) 1.50
Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem (2002) 1.49
Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol (2006) 1.47
ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med (2003) 1.47
Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med (2013) 1.44
Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6. Mol Cell Biol (2007) 1.41
Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol (2012) 1.30
Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem (2007) 1.29
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol (2010) 1.21
The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle. J Gen Virol (2005) 1.20
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem (2007) 1.18
Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol (2008) 1.17
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol (2004) 1.16
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. Exp Cell Res (2012) 1.15
The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A (2008) 1.15
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol (2006) 1.15
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest (2012) 1.13
Integrin-mediated regulation of TGFβ in fibrosis. Biochim Biophys Acta (2012) 1.12
Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol (2011) 1.11
Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol (2002) 1.10
Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol (2004) 1.10
Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res (2004) 1.10
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem (2009) 1.08
Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res (2006) 1.06
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β. Am J Pathol (2012) 1.03
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med (2009) 1.01
Overexpression of the alphavbeta6 integrin in endometrial cancer. Appl Immunohistochem Mol Morphol (2008) 1.01
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res (2006) 1.01
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol (2010) 1.00
Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci (2005) 0.99
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest (2012) 0.98
Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res (2014) 0.97
Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol (2008) 0.96
Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol (2006) 0.96
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem (2011) 0.95
Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Biochemistry (2004) 0.95
Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. Cancer Res (2006) 0.95
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol (2007) 0.94
The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity (2006) 0.94
Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia (2007) 0.94
Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol (2010) 0.94
ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J (2005) 0.91
Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy. J Proteome Res (2007) 0.91