Published in Arthritis Res Ther on October 19, 2010
Reducing Obesity and Cartilage Compression in Knees (ROCCK) | NCT04730557
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Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression. Arthritis Rheum (2013) 1.06
The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Dis Model Mech (2011) 0.97
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Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction. Arthritis Rheumatol (2014) 0.86
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A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res (2001) 1.36
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Identification of a central role for complement in osteoarthritis. Nat Med (2011) 3.11
The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res (2004) 2.92
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The role of synovitis in osteoarthritis pathogenesis. Bone (2012) 2.37
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Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum (2007) 2.07
NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89
Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum (2011) 1.74
Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum (2013) 1.70
NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci U S A (2004) 1.66
Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop. J Bone Miner Res (2009) 1.59
Production of endogenous antibiotics in articular cartilage. Arthritis Rheum (2004) 1.55
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem (2004) 1.53
DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheum (2009) 1.46
CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. J Biol Chem (2003) 1.41
Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem (2005) 1.37
A misplaced lncRNA causes brachydactyly in humans. J Clin Invest (2012) 1.36
Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum (2002) 1.34
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31
Eating bone or adding it: the Wnt pathway decides. Nat Med (2007) 1.30
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A (2005) 1.28
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation. Gene (2006) 1.28
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes. J Pathol (2004) 1.25
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J Immunol (2009) 1.25
In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis Rheum (2013) 1.24
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem (2013) 1.22
Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta. J Biol Chem (2003) 1.22
WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum (2004) 1.21
Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Arthritis Res Ther (2007) 1.21
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum (2004) 1.16
Selection of reliable reference genes for qPCR studies on chondroprotective action. BMC Mol Biol (2007) 1.16
The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis. Biochem Biophys Res Commun (2011) 1.15
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet (2009) 1.13
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol (2004) 1.12
Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J (2010) 1.12
Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates. Mol Pharm (2011) 1.10
Divergent stress responses to IL-1beta, nitric oxide, and tunicamycin by chondrocytes. J Cell Physiol (2005) 1.08
Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum (2003) 1.08
Development of macromolecular prodrug for rheumatoid arthritis. Adv Drug Deliv Rev (2012) 1.07
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol (2008) 1.06
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J (2005) 1.06
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer Res (2003) 1.05
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. J Biol Chem (2011) 1.04
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. Arthritis Res Ther (2010) 1.04
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther (2007) 1.03
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochem Biophys Res Commun (2011) 1.03
Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage. Matrix Biol (2004) 1.03
Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. Biochem J (2002) 1.02
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. J Biol Chem (2010) 1.02
ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem (2004) 1.01
Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol (2009) 1.00
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
Chondrogenesis, joint formation, and articular cartilage regeneration. J Cell Biochem (2009) 1.00
Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS One (2013) 1.00
Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation. J Orthop Res (2012) 0.96
The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2. Biochem J (2003) 0.96
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediators Inflamm (2005) 0.95
Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum. Arch Oral Biol (2008) 0.95
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Arthritis Rheumatol (2014) 0.93
Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors. Arthritis Rheum (2005) 0.92
The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther (2006) 0.92
Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. J Ethnopharmacol (2011) 0.92
Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants. Arthritis Res Ther (2006) 0.91
PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter. J Cell Physiol (2008) 0.91
Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum (2002) 0.91
Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One (2010) 0.91
Production of interleukin-1 receptor antagonist by human articular chondrocytes. Arthritis Res (2002) 0.90
Periarticular bone changes in rheumatoid arthritis: pathophysiological implications and clinical utility. Ann Rheum Dis (2009) 0.90
Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy. PLoS One (2013) 0.90
C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors--Useful cells in study of cartilage metabolism. Ann Anat (2010) 0.90
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis Rheum (2012) 0.89
Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate. Ann Rheum Dis (2012) 0.89
T cell-specific expression of the murine CD3delta promoter. J Biol Chem (2002) 0.88
Bisphosphonates: environmental protection for the joint? Arthritis Rheum (2004) 0.88
Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials. Biomaterials (2005) 0.88
Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice. Pathol Res Pract (2011) 0.87
Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. J Orthop Res (2007) 0.87
The bone, the joints and the Balm of Gilead. Mol Pharm (2011) 0.87
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol (2013) 0.87
Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling. J Bone Miner Res (2013) 0.87
Characterization and regulation of ADAMTS-16. Matrix Biol (2009) 0.87
Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression. Arthritis Res Ther (2012) 0.86
Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. Am J Pathol (2011) 0.85
Role of macrophages in LPS-induced osteoblast and PDL cell apoptosis. Bone (2005) 0.85
Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. J Cell Physiol (2005) 0.85
The role of adsorbed endotoxin in particle-induced stimulation of cytokine release. J Orthop Res (2002) 0.84
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes Nutr (2011) 0.84
Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes. Arthritis Rheum (2010) 0.84