Published in J Biol Chem on March 11, 2003
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis (2008) 1.82
Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem (2008) 1.66
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol (2008) 1.06
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. J Biol Chem (2011) 1.04
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther (2007) 1.03
CD44 modulates Smad1 activation in the BMP-7 signaling pathway. J Cell Biol (2004) 1.03
Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res (2007) 1.01
The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses. Am J Pathol (2011) 1.00
Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin. Mol Cell Endocrinol (2007) 0.98
Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling. Arthritis Res Ther (2009) 0.96
YB-1 coordinates vascular smooth muscle alpha-actin gene activation by transforming growth factor beta1 and thrombin during differentiation of human pulmonary myofibroblasts. Mol Biol Cell (2005) 0.96
Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1. Mol Cell Endocrinol (2006) 0.92
Enhanced cartilage regeneration in MIA/CD-RAP deficient mice. Cell Death Dis (2010) 0.91
Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis. Physiol Genomics (2010) 0.91
CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. J Biol Chem (2013) 0.89
Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients. Arthritis Res Ther (2007) 0.88
Characterization and regulation of ADAMTS-16. Matrix Biol (2009) 0.87
The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis. PLoS One (2013) 0.86
Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol (2013) 0.86
Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha. J Cell Physiol (2005) 0.85
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods Mol Med (2005) 0.83
Principal component analysis for predicting transcription-factor binding motifs from array-derived data. BMC Bioinformatics (2005) 0.82
Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes. Arthritis Res Ther (2012) 0.80
Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair. Bone (2011) 0.80
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. J Neurosci (2012) 0.79
Dose-dependent differential effects of risedronate on gene expression in osteoblasts. Biochem Pharmacol (2011) 0.76
New developments in the treatment of osteoarthritis - focus on biologic agents. Open Access Rheumatol (2015) 0.75
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem (2002) 6.16
Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum (2012) 4.28
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev (2007) 3.57
The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res (2004) 2.92
Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum (2002) 2.66
DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies. PLoS Comput Biol (2007) 2.37
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum (2007) 2.07
Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am (2003) 1.97
NF-kappaB signaling: multiple angles to target OA. Curr Drug Targets (2010) 1.89
Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear. J Bone Joint Surg Am (2012) 1.81
Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum (2013) 1.70
The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Cytokine (2011) 1.67
NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci U S A (2004) 1.66
Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury. J Orthop Res (2006) 1.63
Production of endogenous antibiotics in articular cartilage. Arthritis Rheum (2004) 1.55
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem (2004) 1.53
Lineage and virulence of Streptococcus suis serotype 2 isolates from North America. Emerg Infect Dis (2011) 1.50
DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheum (2009) 1.46
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911. J Immunol (2007) 1.45
Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism. J Biol Chem (2003) 1.45
Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem (2002) 1.43
CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear. J Biol Chem (2003) 1.41
Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem (2005) 1.37
A misplaced lncRNA causes brachydactyly in humans. J Clin Invest (2012) 1.36
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Diversity of Melissococcus plutonius from honeybee larvae in Japan and experimental reproduction of European foulbrood with cultured atypical isolates. PLoS One (2012) 1.32
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31
Adhesive surface proteins of Erysipelothrix rhusiopathiae bind to polystyrene, fibronectin, and type I and IV collagens. J Bacteriol (2003) 1.31
Eating bone or adding it: the Wnt pathway decides. Nat Med (2007) 1.30
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis. Proc Natl Acad Sci U S A (2005) 1.28
Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem (2011) 1.28
Solution structure and dynamics of a prototypical chordin-like cysteine-rich repeat (von Willebrand Factor type C module) from collagen IIA. J Biol Chem (2004) 1.27
Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. J Biol Chem (2006) 1.26
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes. J Pathol (2004) 1.25
In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae. Arthritis Rheum (2013) 1.24
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem (2013) 1.22
Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation. Appl Environ Microbiol (2013) 1.22
Complete genome sequence of Melissococcus plutonius ATCC 35311. J Bacteriol (2011) 1.21
WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum (2004) 1.21
TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. J Cell Sci (2006) 1.21
Streptococcus suis in humans, Thailand. Emerg Infect Dis (2008) 1.21
Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes. J Immunol (2002) 1.17
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum (2004) 1.16
Selection of reliable reference genes for qPCR studies on chondroprotective action. BMC Mol Biol (2007) 1.16
The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis. Biochem Biophys Res Commun (2011) 1.15
A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet (2009) 1.13
Heritability of articular cartilage regeneration and its association with ear wound healing in mice. Arthritis Rheum (2012) 1.12
Alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily. J Biol Chem (2003) 1.12
Physiological loading of joints prevents cartilage degradation through CITED2. FASEB J (2010) 1.12
Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other? Arthritis Res Ther (2010) 1.11
Loss of capsule among Streptococcus suis isolates from porcine endocarditis and its biological significance. J Med Microbiol (2011) 1.11
CCAAT/enhancer-binding proteins beta and delta mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1 beta. J Biol Chem (2002) 1.10
The minor pilin subunit Sgp2 is necessary for assembly of the pilus encoded by the srtG cluster of Streptococcus suis. J Bacteriol (2010) 1.10
Genetic organization and preferential distribution of putative pilus gene clusters in Streptococcus suis. Vet Microbiol (2009) 1.10
Recent advances in biomarkers in osteoarthritis. Curr Opin Rheumatol (2011) 1.09
CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β. J Biol Chem (2010) 1.09
Divergent stress responses to IL-1beta, nitric oxide, and tunicamycin by chondrocytes. J Cell Physiol (2005) 1.08
Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum (2003) 1.08
Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection. Arthritis Rheum (2008) 1.08
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol (2008) 1.06
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J (2005) 1.06
Outcome of rotational acetabular osteotomy for early hip osteoarthritis secondary to dysplasia related to femoral head shape: 49 hips followed for 10-17 years. Acta Orthop (2008) 1.05
The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer Res (2003) 1.05
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. J Biol Chem (2011) 1.04
Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5' splice site and an adjacent intronic stem-loop cis element. J Biol Chem (2005) 1.04
Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum (2010) 1.04
Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther (2007) 1.03
Single high-energy impact load causes posttraumatic OA in young rabbits via a decrease in cellular metabolism. J Orthop Res (2009) 1.03
Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochem Biophys Res Commun (2011) 1.03
Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage. Matrix Biol (2004) 1.03
Revision with impacted bone allografts and the Kerboull cross plate for massive bone defect of the acetabulum. J Arthroplasty (2009) 1.02
Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase. Biochem J (2002) 1.02
Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol (2007) 1.02
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. J Biol Chem (2010) 1.02
Inflammatory mediators: tracing links between obesity and osteoarthritis. Crit Rev Eukaryot Gene Expr (2011) 1.01
Obesity and cardiovascular risk factors among men and women aged 40 years and older in a rural area of Japan. J Physiol Anthropol (2006) 1.01
ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem (2004) 1.01
Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res (2007) 1.01
Inferring protein-DNA dependencies using motif alignments and mutual information. Bioinformatics (2007) 1.01
Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol (2009) 1.00
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
Chondrogenesis, joint formation, and articular cartilage regeneration. J Cell Biochem (2009) 1.00
Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS One (2013) 1.00
Long-term outcome of Ludloff's medial approach for open reduction of developmental dislocation of the hip in relation to the age at operation. Int Orthop (2009) 0.99
Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem (2005) 0.98
Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis. J Clin Microbiol (2014) 0.98
Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA. J Biol Chem (2007) 0.97
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J Clin Invest (2014) 0.97
Osteonecrosis in stroke-prone spontaneously hypertensive rats: effect of glucocorticoid. J Orthop Sci (2007) 0.96