Published in J Med Chem on November 12, 2010
TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol (2014) 1.48
7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2011) 1.40
Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes Brain Behav (2012) 1.31
Retracted Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci (2011) 1.30
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov (2013) 1.29
Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol (2014) 1.18
7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology (2013) 1.09
Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet (2013) 1.08
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. Proc Natl Acad Sci U S A (2013) 1.03
TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Int J Mol Sci (2013) 0.99
Neurotrophic natural products: chemistry and biology. Angew Chem Int Ed Engl (2013) 0.96
BDNF - a key transducer of antidepressant effects. Neuropharmacology (2015) 0.93
Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. J Neurosci (2013) 0.92
Novel small molecule activators of the Trk family of receptor tyrosine kinases. Biochim Biophys Acta (2012) 0.91
7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. Psychopharmacology (Berl) (2013) 0.89
Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. J Med Chem (2012) 0.89
Synaptic regulation of affective behaviors; role of BDNF. Neuropharmacology (2013) 0.89
The Small-Molecule TrkB Agonist 7, 8-Dihydroxyflavone Decreases Hippocampal Newborn Neuron Death After Traumatic Brain Injury. J Neuropathol Exp Neurol (2015) 0.88
Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists. J Neurosci (2013) 0.87
Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice. Chem Biol (2015) 0.86
O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology (2013) 0.84
7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo. Biochem Biophys Res Commun (2012) 0.84
7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegener (2016) 0.84
Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol (2015) 0.83
Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor. J Biol Chem (2014) 0.80
Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins. Int J Mol Sci (2015) 0.80
Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta (2015) 0.79
Post-Injury Treatment of 7,8-Dihydroxyflavone Promotes Neurogenesis in the Hippocampus of the Adult Mouse. J Neurotrauma (2016) 0.78
7,8-Dihydroxyflavone, a Tropomyosin-Kinase Related Receptor B Agonist, Produces Fast-Onset Antidepressant-Like Effects in Rats Exposed to Chronic Mild Stress. Psychiatry Investig (2016) 0.75
Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett (2014) 0.75
Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP(+)-treated Monkeys. Sci Rep (2016) 0.75
Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test. Exp Biol Med (Maywood) (2016) 0.75
Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway. J Cell Mol Med (2016) 0.75
Aging impairs dendrite morphogenesis of newborn neurons and is rescued by 7, 8-dihydroxyflavone. Aging Cell (2017) 0.75
Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury. Neural Regen Res (2017) 0.75
7, 8, 3'-Trihydroxyflavone Promotes Neurite Outgrowth and Protects Against Bupivacaine-Induced Neurotoxicity in Mouse Dorsal Root Ganglion Neurons. Med Sci Monit (2016) 0.75
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci (2000) 9.12
Depression: a new animal model sensitive to antidepressant treatments. Nature (1977) 8.76
Neurobiology of depression. Neuron (2002) 8.56
Advances in flavonoid research since 1992. Phytochemistry (2000) 7.78
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci (2002) 5.17
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci (1995) 5.10
Physiology of the neurotrophins. Annu Rev Neurosci (1996) 4.82
Adult hippocampal neurogenesis in depression. Nat Neurosci (2007) 4.79
Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci (2002) 4.02
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci U S A (2006) 3.39
Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A (2004) 3.37
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol (2007) 3.32
Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci (2008) 3.13
A chemical-genetic approach to studying neurotrophin signaling. Neuron (2005) 2.93
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol (2005) 2.69
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav (1997) 2.67
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci (2003) 2.66
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A (2010) 2.57
Role of neurotrophic factors in depression. Curr Opin Pharmacol (2006) 2.39
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry (2008) 2.35
The changing scene of neurotrophic factors. Trends Neurosci (1991) 2.32
Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci (2007) 2.12
Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry (2007) 1.80
Neurotrophins and depression. Trends Pharmacol Sci (1999) 1.70
Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Trends Neurosci (2005) 1.65
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharmacology (2007) 1.64
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A (2006) 1.61
Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment. CNS Neurol Disord Drug Targets (2007) 1.47
Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochem Soc Trans (2007) 1.36
Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. J Biol Chem (2002) 1.30
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A (2001) 1.30
Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. J Neurochem (2007) 1.24
Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol (2004) 1.23
(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. J Neurochem (2007) 1.13
Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc (2008) 1.10
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cell Mol Neurobiol (2005) 1.08
The when and where of BDNF and the antidepressant response. Biol Psychiatry (2008) 0.96
Catecholic flavonoids acting as telomerase inhibitors. J Med Chem (2004) 0.83
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A (2010) 2.57
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31
Identification of cell cycle-regulated genes in fission yeast. Mol Biol Cell (2004) 2.29
Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am J Psychiatry (2010) 2.25
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci (2003) 2.06
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci (2010) 1.89
Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One (2009) 1.77
Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A (2010) 1.72
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J (2006) 1.67
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood (2007) 1.65
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem (2004) 1.63
Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene (2004) 1.61
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol (2007) 1.54
Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A (2010) 1.53
Systematic deletion analysis of fission yeast protein kinases. Eukaryot Cell (2005) 1.51
Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A (2006) 1.49
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem (2004) 1.47
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci (2012) 1.45
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci U S A (2004) 1.43
Anticipating synchronization of chaotic systems with time delay and parameter mismatch. Chaos (2009) 1.38
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem (2007) 1.35
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J (2005) 1.35
Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L. Proc Natl Acad Sci U S A (2004) 1.34
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity (2007) 1.33
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A (2012) 1.32
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol (2007) 1.31
A global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid. Proc Natl Acad Sci U S A (2002) 1.29
PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J (2004) 1.28
N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A (2010) 1.28
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol (2008) 1.27
Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Oncogene (2003) 1.27
Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell (2008) 1.25
Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry (2002) 1.25
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proc Natl Acad Sci U S A (2007) 1.24
Ebp1 isoforms distinctively regulate cell survival and differentiation. Proc Natl Acad Sci U S A (2006) 1.23
Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J Biol Chem (2002) 1.22
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. Proc Natl Acad Sci U S A (2008) 1.22
Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival. Proc Natl Acad Sci U S A (2007) 1.22
Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol (2006) 1.20
Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Mol Cell (2005) 1.18
Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity (2012) 1.17
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood (2013) 1.15
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol (2011) 1.15
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. J Appl Physiol (1985) (2011) 1.14
Novel genetic mutations in a sporadic port-wine stain. JAMA Dermatol (2014) 1.12
Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci U S A (2007) 1.12
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem (2009) 1.10
Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. J Biol Chem (2006) 1.10
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res (2008) 1.10
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity (2007) 1.10
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity (2012) 1.09
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci (2011) 1.08
Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum Mol Genet (2013) 1.08
Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci U S A (2008) 1.08
Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood (2009) 1.06
YAP/TEAD-mediated transcription controls cellular senescence. Cancer Res (2013) 1.06
Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. Mol Biol Cell (2008) 1.03
Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol (2009) 1.03
Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol (2009) 1.03
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. Proc Natl Acad Sci U S A (2013) 1.03
N-acetyl serotonin derivatives as potent neuroprotectants for retinas. Proc Natl Acad Sci U S A (2012) 1.02
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Proc Natl Acad Sci U S A (2008) 1.02
Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin. Proc Natl Acad Sci U S A (2010) 1.01
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome. Proc Natl Acad Sci U S A (2008) 1.01
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood (2007) 1.00
Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes (2010) 1.00