Hal E Broxmeyer

Author PubWeight™ 134.24‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc 2015 4.70
2 Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003 4.19
3 NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 2003 3.98
4 Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004 3.92
5 Umbilical cord blood transplantation: the first 25 years and beyond. Blood 2013 2.79
6 SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008 2.67
7 Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol 2007 2.60
8 A noncytotoxic DsRed variant for whole-cell labeling. Nat Methods 2008 2.34
9 Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 2013 2.12
10 Immune responses in 4-1BB (CD137)-deficient mice. J Immunol 2002 1.74
11 Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist. Transfusion 2005 1.71
12 SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells. Stem Cells 2005 1.68
13 Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells. J Immunol 2002 1.63
14 Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells. J Immunol 2006 1.56
15 Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev 2007 1.50
16 Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood 2007 1.48
17 New approaches for improving engraftment after cord blood transplantation. Biol Blood Marrow Transplant 2009 1.46
18 Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med 2010 1.42
19 P21waf-1-Chk1 pathway monitors G1 phase microtubule integrity and is crucial for restriction point transition. Cell Cycle 2002 1.40
20 Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells. Blood 2003 1.40
21 Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J Immunol 2002 1.39
22 SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood 2010 1.36
23 Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow. Stem Cells 2008 1.33
24 Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells 2007 1.30
25 Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution. Blood 2002 1.30
26 Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood 2009 1.29
27 Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines. Blood 2002 1.26
28 Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells. Cell Cycle 2010 1.25
29 BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production. Blood 2004 1.20
30 Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1alpha(CXCL12)/CXCR4 axis. Blood 2004 1.20
31 Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells 2013 1.19
32 SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells 2014 1.19
33 Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types. Blood 2013 1.18
34 In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev 2013 1.17
35 Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist. Support Cancer Ther 2004 1.16
36 Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not. Stem Cells 2006 1.15
37 Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells. Exp Hematol 2008 1.13
38 Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol 2012 1.13
39 A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities. J Virol 2007 1.12
40 Sirtuin 1, stem cells, aging, and stem cell aging. Curr Opin Hematol 2008 1.11
41 Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells. Stem Cells 2005 1.09
42 Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood 2012 1.05
43 CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice. Exp Hematol 2003 1.05
44 Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation. Blood 2009 1.04
45 Macrophage colony-stimulating factor drives cord blood monocyte differentiation into IL-10(high)IL-12absent dendritic cells with tolerogenic potential. J Immunol 2005 1.04
46 SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev 2011 1.02
47 Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e. Stem Cells Dev 2004 1.00
48 Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4. Blood 2005 1.00
49 Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis. Blood 2003 1.00
50 Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice. Blood Cells Mol Dis 2011 0.99
51 AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice. Exp Hematol 2008 0.98
52 Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis. Stem Cells Dev 2007 0.97
53 STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood 2011 0.97
54 Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12. Blood 2005 0.96
55 CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells. J Immunol 2009 0.95
56 Muscle-derived Gr1(dim)CD11b(+) cells enhance neovascularization in an ischemic hind limb mouse model. Blood 2010 0.95
57 Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45. Blood Cells Mol Dis 2006 0.94
58 Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function. Curr Opin Hematol 2011 0.94
59 CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation. Front Biosci 2008 0.94
60 Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells. J Immunol 2007 0.93
61 Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity. J Clin Invest 2010 0.93
62 TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Blood 2011 0.93
63 Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance. Crit Rev Oncol Hematol 2010 0.92
64 P-selectin enhances generation of CD14+CD16+ dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes. J Immunol 2003 0.92
65 Modulation of cord blood CD8+ T-cell effector differentiation by TGF-beta1 and 4-1BB costimulation. Blood 2004 0.91
66 SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl. Blood 2006 0.91
67 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. Stem Cells 2012 0.90
68 Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells. Stem Cells Dev 2012 0.90
69 4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34+ progenitor cells. J Hematother Stem Cell Res 2002 0.89
70 Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. Immunology 2002 0.89
71 TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors. Blood 2007 0.89
72 Role of 4-1BB (CD137) in the functional activation of cord blood CD28(-)CD8(+) T cells. Blood 2002 0.89
73 Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34⁺ cells in a murine model of umbilical cord blood transplantation. Blood Cells Mol Dis 2013 0.88
74 Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1. Blood 2004 0.87
75 Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: implications for hematopoietic stem cell transplantation. Stem Cells Dev 2006 0.87
76 Toll-like receptor 2 mediates proliferation, survival, NF-kappaB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells. Stem Cells Dev 2010 0.87
77 Dynamic expression of specific miRNAs during erythroid differentiation of human embryonic stem cells. Mol Cells 2012 0.87
78 The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation. Blood 2006 0.87
79 The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation. Curr Opin Hematol 2013 0.87
80 C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors. Blood 2002 0.87
81 The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. J Biol Chem 2002 0.86
82 Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood 2011 0.85
83 Comparative proteomic analysis of human CD34+ stem/progenitor cells and mature CD15+ myeloid cells. Stem Cells 2004 0.85
84 Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14+CD16++ cells derived from human monocytes. Biochem Biophys Res Commun 2004 0.84
85 Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines. J Hematother Stem Cell Res 2003 0.84
86 Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line. Exp Hematol 2002 0.84
87 Stem cells: shibboleths of development. Stem Cells Dev 2004 0.83
88 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells. Blood 2007 0.83
89 C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells. Stem Cells Dev 2012 0.83
90 Nonmarrow hematopoiesis occurs in a hyaluronic-acid-rich node and duct system in mice. Stem Cells Dev 2014 0.82
91 Sirt1, notch and stem cell "age asymmetry". Cell Cycle 2008 0.82
92 A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling. Cell Cycle 2007 0.82
93 Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia. J Clin Oncol 2003 0.81
94 Cells enter a unique intermediate 4N stage, not 4N-G1, after aborted mitosis. Cell Cycle 2007 0.81
95 Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction. J Immunol 2011 0.80
96 Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress. Stem Cells Dev 2013 0.80
97 Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12. Blood 2006 0.80
98 Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells. Blood 2006 0.80
99 Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Blood 2003 0.80
100 Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells 2015 0.79
101 Spontaneously differentiated GATA6-positive human embryonic stem cells represent an important cellular step in human embryonic development; they are not just an artifact of in vitro culture. Stem Cells Dev 2013 0.79
102 Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide. Exp Hematol 2003 0.79
103 Effect of leukotactin-1 on the protection in vivo of myeloid progenitor cells against cytotoxic chemotherapeutics. J Hematother Stem Cell Res 2003 0.78
104 A ROSy future for metabolic regulation of HSC division. Nat Med 2012 0.78
105 Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro. Exp Hematol 2011 0.78
106 Predicting the quality of transplantable cord blood collections through prefreeze and postthaw Apgar scoring. Transfusion 2012 0.77
107 Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells. Exp Mol Med 2003 0.77
108 The chemokine CCL21 protects normal marrow progenitors from Ara-C cytotoxicity. Cancer Chemother Pharmacol 2002 0.77
109 Inhibiting HDAC for human hematopoietic stem cell expansion. J Clin Invest 2014 0.77
110 SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function. PLoS One 2013 0.76
111 Src kinase, but not the src kinase family member p56lck, mediates stromal cell-derived factor 1alpha/CXCL12-induced chemotaxis of a T cell line. J Hematother Stem Cell Res 2002 0.76
112 Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling. Stem Cells Dev 2008 0.76
113 Tension no longer, as Tensin2 is identified as a long-sought-after link between thrombopoietin-induced receptor signaling and activation of the PI3K/Akt pathway. Cell Cycle 2011 0.75
114 Editorial: Scrambling for a response to G-CSF. J Leukoc Biol 2011 0.75
115 Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells 2015 0.75
116 Osteoprotegerin inhibits proliferation of myeloid progenitor cells. J Hematother Stem Cell Res 2003 0.75
117 Retraction. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1. Blood 2006 0.75
118 CD34(+++) STEM/PROGENITOR CELLS PURIFIED FROM CRYOPRESERVED NORMAL CORD BLOOD CAN BE TRANSDUCED WITH HIGH EFFICIENCY BY A RETROVIRAL VECTOR AND EXPANDED EX VIVO WITH STABLE INTEGRATION AND EXPRESSION OF FANCONI ANEMIA COMPLEMENTATION C GENE. Cell Transplant 1995 0.75
119 A role for intracellular and extracellular DEK in regulating hematopoiesis. Curr Opin Hematol 2017 0.75
120 Generating autologous hematopoietic cells from human-induced pluripotent stem cells through ectopic expression of transcription factors. Curr Opin Hematol 2017 0.75