Published in Nat Protoc on August 26, 2010
Molecular nutrition research: the modern way of performing nutritional science. Nutrients (2012) 1.18
An integrative analysis of the transcriptome and proteome of the pulp of a spontaneous late-ripening sweet orange mutant and its wild type improves our understanding of fruit ripening in citrus. J Exp Bot (2014) 1.05
Mass spectrometry for translational proteomics: progress and clinical implications. Genome Med (2012) 1.02
Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One (2013) 0.99
Proteomic analysis reveals resistance mechanism against biofuel hexane in Synechocystis sp. PCC 6803. Biotechnol Biofuels (2012) 0.96
A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice. Oncotarget (2014) 0.92
Comparison of protein expression ratios observed by sixplex and duplex TMT labeling method. J Proteome Res (2012) 0.83
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics (2014) 0.82
Quantitative phosphoproteomics analysis of nitric oxide-responsive phosphoproteins in cotton leaf. PLoS One (2014) 0.82
Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression. Front Microbiol (2016) 0.81
Mass spectrometry-based proteomics for pre-eclampsia and preterm birth. Int J Mol Sci (2015) 0.81
The CJIE1 prophage of Campylobacter jejuni affects protein expression in growth media with and without bile salts. BMC Microbiol (2014) 0.81
A Comprehensive Guide for Performing Sample Preparation and Top-Down Protein Analysis. Proteomes (2017) 0.81
A multi-omic analysis of an Enterococcus faecium mutant reveals specific genetic mutations and dramatic changes in mRNA and protein expression. BMC Microbiol (2013) 0.80
Protein quantitation using iTRAQ: Review on the sources of variations and analysis of nonrandom missingness. Stat Interface (2012) 0.80
Dynamic Proteomic Characteristics and Network Integration Revealing Key Proteins for Two Kernel Tissue Developments in Popcorn. PLoS One (2015) 0.80
ZIC-cHILIC as a fractionation method for sensitive and powerful shotgun proteomics. Nat Protoc (2012) 0.80
Complementary serum proteomic analysis of autoimmune hepatitis in mice and patients. J Transl Med (2013) 0.80
CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway. Mol Carcinog (2015) 0.79
Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer's disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies. Oncotarget (2015) 0.78
Comparative proteomics study on liver mitochondria of primary biliary cirrhosis mouse model. BMC Gastroenterol (2013) 0.78
Transcriptomic and proteomic analysis of pre-diapause and non-diapause eggs of migratory locust, Locusta migratoria L. (Orthoptera: Acridoidea). Sci Rep (2015) 0.77
Proteomic analysis of nasal epithelial cells from cystic fibrosis patients. PLoS One (2014) 0.77
Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells. Cancer Sci (2016) 0.76
Cerebrospinal fluid biomarker candidates associated with human WNV neuroinvasive disease. PLoS One (2014) 0.76
Sexual crossing of thermophilic fungus Myceliophthora heterothallica improved enzymatic degradation of sugar beet pulp. Biotechnol Biofuels (2016) 0.75
Differential Protein Expression Marks the Transition From Infection With Opisthorchis viverrini to Cholangiocarcinoma. Mol Cell Proteomics (2017) 0.75
Quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism in Arabidopsis thaliana and Brassica oleracea. J Exp Bot (2016) 0.75
Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification. Sci Rep (2016) 0.75
Comparative study of serum proteomes in Legg-Calve-Perthes disease. BMC Musculoskelet Disord (2015) 0.75
Proteome Profile and Quantitative Proteomic Analysis of Buffalo (Bubalusbubalis) Follicular Fluid during Follicle Development. Int J Mol Sci (2016) 0.75
GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression. PLoS One (2016) 0.75
Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ). J Lipid Res (2011) 0.75
A proteome map of primary cultured rat Schwann cells. Proteome Sci (2012) 0.75
CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival. Sci Rep (2017) 0.75
Comparative proteomic analysis of pituitary glands from Huoyan geese between pre-laying and laying periods using an iTRAQ-based approach. PLoS One (2017) 0.75
ITRAQ-based quantitative proteomic analysis of Cynops orientalis limb regeneration. BMC Genomics (2017) 0.75
Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts. Sci Rep (2017) 0.75
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol Cell Proteomics (2004) 19.05
Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS. Anal Chem (2003) 6.63
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A (2007) 4.80
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Addressing accuracy and precision issues in iTRAQ quantitation. Mol Cell Proteomics (2010) 3.10
Protein labeling by iTRAQ: a new tool for quantitative mass spectrometry in proteome research. Proteomics (2007) 2.97
Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature (2009) 2.70
Properties of 13C-substituted arginine in stable isotope labeling by amino acids in cell culture (SILAC). J Proteome Res (2003) 2.51
Quantitative analysis of synaptic phosphorylation and protein expression. Mol Cell Proteomics (2007) 2.23
Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2005) 2.22
Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS. J Proteome Res (2006) 2.10
Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases. Mol Cell Proteomics (2007) 2.08
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood (2006) 1.92
Protease-catalyzed incorporation of 18O into peptide fragments and its application for protein sequencing by electrospray and matrix-assisted laser desorption/ionization mass spectrometry. Electrophoresis (1996) 1.71
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics (2007) 1.19
Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem (2005) 1.18
Search for potential markers for prostate cancer diagnosis, prognosis and treatment in clinical tissue specimens using amine-specific isobaric tagging (iTRAQ) with two-dimensional liquid chromatography and tandem mass spectrometry. J Proteome Res (2008) 1.05
Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis. J Proteome Res (2009) 1.00
Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletion. Proteomics (2007) 0.97
Comparative time-dependent analysis of potential inflammation biomarkers in lymphoma-bearing SJL mice. J Proteome Res (2007) 0.86
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene (2005) 2.77
Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature (2009) 2.70
Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics (2005) 2.26
Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases. Mol Cell Proteomics (2007) 2.08
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood (2006) 1.92
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst (2006) 1.83
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry. J Magn Reson Imaging (2003) 1.45
Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics (2005) 1.42
Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol (2008) 1.38
Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra. NMR Biomed (2006) 1.35
Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice. Am J Physiol Heart Circ Physiol (2004) 1.34
PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics (2004) 1.34
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res (2006) 1.29
Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models. J Natl Cancer Inst (2003) 1.29
A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc (2009) 1.26
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene (2005) 1.25
A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood (2006) 1.24
Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler Thromb Vasc Biol (2005) 1.23
An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis. NMR Biomed (2008) 1.22
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics (2007) 1.19
Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects. Radiology (2012) 1.18
Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study. Magn Reson Med (2003) 1.17
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol (2010) 1.16
Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL. J Biol Chem (2004) 1.15
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy. Cancer Chemother Pharmacol (2011) 1.15
Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts. J Oncol (2010) 1.14
Tumor R2* is a prognostic indicator of acute radiotherapeutic response in rodent tumors. J Magn Reson Imaging (2004) 1.13
Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol (2008) 1.13
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells (2014) 1.13
Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel. Magn Reson Med (2008) 1.11
Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers. Mol Cancer (2010) 1.10
Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. Circ Cardiovasc Genet (2009) 1.10
Loss of PKC-delta alters cardiac metabolism. Am J Physiol Heart Circ Physiol (2004) 1.10
Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal Chem (2011) 1.07
An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR. NMR Biomed (2008) 1.05
Differentiation of metastases from high-grade gliomas using short echo time 1H spectroscopy. J Magn Reson Imaging (2004) 1.04
Relative quantification in proteomics: new approaches for biochemistry. Trends Biochem Sci (2006) 1.02
The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. Adv Enzyme Regul (2009) 1.01
The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues. J Am Soc Mass Spectrom (2007) 1.01
Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res (2008) 1.00
Proteomics techniques and their application to hematology. Blood (2004) 0.99
A method for interleaved acquisition of a vascular input function for dynamic contrast-enhanced MRI in experimental rat tumours. NMR Biomed (2004) 0.98
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts. Neoplasia (2008) 0.97
Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database. J Neurosurg (2006) 0.96
Correlations between in vivo (1)H MRS and ex vivo (1)H HRMAS metabolite measurements in adult human gliomas. J Magn Reson Imaging (2010) 0.96
Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting. Mol Cell Proteomics (2007) 0.96
Systematic proteome and transcriptome analysis of stem cell populations. Cell Cycle (2006) 0.95
Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. Cancer Res (2003) 0.94
Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development. Eur Radiol (2009) 0.94
Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126. Microvasc Res (2006) 0.93
Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging. Neoplasia (2005) 0.93
Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta. Circ Res (2004) 0.92
Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery. J Proteome Res (2012) 0.92
THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. Br J Haematol (2008) 0.92
The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. J Cell Sci (2006) 0.92
Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model. Neoplasia (2004) 0.91
Vascular proteomics: linking proteomic and metabolomic changes. Proteomics (2004) 0.91
The response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo 1H magnetic resonance spectroscopy. Neoplasia (2006) 0.91
Guanidination chemistry for qualitative and quantitative proteomics. Rapid Commun Mass Spectrom (2006) 0.91
Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One (2011) 0.91
Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. Protein Sci (2007) 0.90
Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease. Magn Reson Med (2010) 0.90
Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers. Cancer Res (2011) 0.89
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA (2011) 0.89
THOC5 couples M-CSF receptor signaling to transcription factor expression. Cell Signal (2008) 0.89
The application of quantification techniques in proteomics for biomedical research. Mass Spectrom Rev (2012) 0.88
Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood (2004) 0.88
Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia. Philos Trans R Soc Lond B Biol Sci (2004) 0.88
Prospective diagnostic performance evaluation of single-voxel 1H MRS for typing and grading of brain tumours. NMR Biomed (2011) 0.88
Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.88
Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126. Int J Radiat Oncol Biol Phys (2007) 0.87
The potential for proteomic definition of stem cell populations. Exp Hematol (2003) 0.87
Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise. J Appl Physiol (1985) (2013) 0.87
The requirement for proteomics to unravel stem cell regulatory mechanisms. J Cell Physiol (2011) 0.87
Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood (2011) 0.86
Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosomes Cancer (2007) 0.86
Apparent T(2) relaxation times of lipid and macromolecules: a study of high-grade tumor spectra. J Magn Reson Imaging (2008) 0.86
The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia. Mol Biotechnol (2007) 0.86
Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T. Magn Reson Med (2009) 0.86
Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy. Clin Cancer Res (2005) 0.86
Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). FEBS Lett (2008) 0.85
Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis. Proteomics (2008) 0.85
Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice. J Magn Reson Imaging (2008) 0.84
Magnetic resonance spectroscopy of cancer metabolism and response to therapy. Radiat Res (2012) 0.84
In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors. Int J Radiat Oncol Biol Phys (2004) 0.83
A longitudinal study of R2* and R2 magnetic resonance imaging relaxation rate measurements in murine liver after a single administration of 3 different iron oxide-based contrast agents. Invest Radiol (2005) 0.83
BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response. J Proteomics (2012) 0.83
Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model. Int J Radiat Oncol Biol Phys (2008) 0.83