Published in Blood on February 05, 2004
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci (2004) 1.81
Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J Bone Miner Res (2006) 1.52
Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration. Mol Pharmacol (2011) 0.98
Clinical proteomics: present and future prospects. Clin Biochem Rev (2006) 0.97
Quantitative proteomics: assessing the spectrum of in-gel protein detection methods. J Chem Biol (2010) 0.88
The Ah receptor in stem cell cycling, regulation, and quiescence. Ann N Y Acad Sci (2014) 0.87
Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment. J Proteome Res (2011) 0.81
Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer. J Thorac Oncol (2014) 0.80
Age-related Deterioration of Hematopoietic Stem Cells. Int J Stem Cells (2008) 0.78
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
Flagellar motility is required for the viability of the bloodstream trypanosome. Nature (2006) 4.71
Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58
A systematic approach to modeling, capturing, and disseminating proteomics experimental data. Nat Biotechnol (2003) 3.57
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides. Nat Methods (2005) 2.81
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature (2004) 2.73
Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature (2009) 2.70
Dynamics of protein turnover, a missing dimension in proteomics. Mol Cell Proteomics (2002) 2.70
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med (2002) 2.68
Multiplexed absolute quantification for proteomics using concatenated signature peptides encoded by QconCAT genes. Nat Protoc (2006) 2.37
PTEN: The down side of PI 3-kinase signalling. Cell Signal (2002) 2.34
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol (2002) 2.31
Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics (2005) 2.26
Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC. J Proteome Res (2009) 2.18
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases. Mol Cell Proteomics (2007) 2.08
Patient information on prescribed drugs. BMJ (2011) 2.03
Not to be taken as directed. BMJ (2003) 2.00
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood (2006) 1.92
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J (2004) 1.88
Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. Science (2013) 1.87
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci (2004) 1.81
Proteome dynamics in complex organisms: using stable isotopes to monitor individual protein turnover rates. Proteomics (2005) 1.69
"Expert patient"--dream or nightmare? BMJ (2004) 1.63
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59
An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry. Phytochemistry (2003) 1.57
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake. J Biol Chem (2008) 1.55
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
Absolute multiplexed quantitative analysis of protein expression during muscle development using QconCAT. Mol Cell Proteomics (2007) 1.45
Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics (2005) 1.42
Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. Toxicol Sci (2002) 1.40
Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci U S A (2010) 1.40
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci (2006) 1.36
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells. EMBO J (2006) 1.34
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proc Natl Acad Sci U S A (2010) 1.34
PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics (2004) 1.34
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell (2009) 1.30
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity (2010) 1.29
PTEN is destabilized by phosphorylation on Thr366. Biochem J (2007) 1.28
Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood (2006) 1.27
A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc (2009) 1.26
Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC-MS/MS. Nat Protoc (2010) 1.26
Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene (2005) 1.25
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice. J Proteome Res (2006) 1.25
A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood (2006) 1.24
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics (2007) 1.19
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem (2009) 1.17
Evaluation of saturation labelling two-dimensional difference gel electrophoresis fluorescent dyes. Proteomics (2003) 1.17
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol (2006) 1.16
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol (2010) 1.16
Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy. Proteomics (2011) 1.16
Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL. J Biol Chem (2004) 1.15
Differential redox regulation within the PTP superfamily. Cell Signal (2007) 1.15
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity. Sci Signal (2012) 1.15
Doctors' stress responses and poor communication performance in simulated bad-news consultations. Acad Med (2009) 1.13
Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol (2007) 1.13
Systematic integration of experimental data and models in systems biology. BMC Bioinformatics (2010) 1.13
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells (2014) 1.13
CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches. Mol Cell Proteomics (2011) 1.12
Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach. Mol Cell Proteomics (2011) 1.11
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res (2006) 1.08
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem (2007) 1.08
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J (2002) 1.08
Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal Chem (2011) 1.07
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem (2010) 1.05
Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA. FEBS Lett (2005) 1.05
Demography and management of childhood established renal failure in the UK (chapter 13). Nephrol Dial Transplant (2007) 1.04
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor. Biochem J (2012) 1.03
Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum. Mol Biol Cell (2004) 1.03
PepSeeker: a database of proteome peptide identifications for investigating fragmentation patterns. Nucleic Acids Res (2006) 1.03
Polymorphism in major urinary proteins: molecular heterogeneity in a wild mouse population. J Chem Ecol (2002) 1.03
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells. J Biol Chem (2012) 1.03
Measuring cancer care coordination: development and validation of a questionnaire for patients. BMC Cancer (2011) 1.02
Stable isotope labelling in vivo as an aid to protein identification in peptide mass fingerprinting. Proteomics (2002) 1.02
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J (2004) 1.02
Relative quantification in proteomics: new approaches for biochemistry. Trends Biochem Sci (2006) 1.02
The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues. J Am Soc Mass Spectrom (2007) 1.01