Published in Nucleic Acids Res on March 25, 1990
Functions of the gene products of Escherichia coli. Microbiol Rev (1993) 15.51
Synonymous but not the same: the causes and consequences of codon bias. Nat Rev Genet (2010) 5.37
Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis. Proc Natl Acad Sci U S A (1999) 5.04
Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol Rev (1996) 4.93
Linkage map of Escherichia coli K-12, edition 10: the traditional map. Microbiol Mol Biol Rev (1998) 4.18
Molecular genetics and pathogenesis of Clostridium perfringens. Microbiol Rev (1991) 3.81
Transient ribosomal attenuation coordinates protein synthesis and co-translational folding. Nat Struct Mol Biol (2009) 3.19
Reduced synonymous substitution rate at the start of enterobacterial genes. Nucleic Acids Res (1993) 2.94
Ribosome-mediated translational pause and protein domain organization. Protein Sci (1996) 2.20
TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc Natl Acad Sci U S A (1991) 2.07
Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host. PLoS One (2008) 2.07
Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system. J Bacteriol (1993) 2.05
Growth rate dependence of transfer RNA abundance in Escherichia coli. EMBO J (1990) 1.91
Characterization of the rfc region of Shigella flexneri. J Bacteriol (1994) 1.84
Codon choice and potential complementarity between mRNA downstream of the initiation codon and bases 1471-1480 in 16S ribosomal RNA affects expression of glnS. Nucleic Acids Res (1991) 1.51
A codon window in mRNA downstream of the initiation codon where NGG codons give strongly reduced gene expression in Escherichia coli. Nucleic Acids Res (2004) 1.47
Overexpression of an mRNA dependent on rare codons inhibits protein synthesis and cell growth. J Bacteriol (1996) 1.43
Decoding with the A:I wobble pair is inefficient. Nucleic Acids Res (1995) 1.40
You're one in a googol: optimizing genes for protein expression. J R Soc Interface (2009) 1.39
Generic algorithm to predict the speed of translational elongation: implications for protein biogenesis. PLoS One (2009) 1.26
Identification of the O antigen polymerase (rfc) gene in Escherichia coli O4 by insertional mutagenesis using a nonpolar chloramphenicol resistance cassette. J Bacteriol (1996) 1.26
Isolation of cmr, a novel Escherichia coli chloramphenicol resistance gene encoding a putative efflux pump. J Bacteriol (1996) 1.21
Effects of codon distributions and tRNA competition on protein translation. Biophys J (2008) 1.21
Intragenic spatial patterns of codon usage bias in prokaryotic and eukaryotic genomes. Genetics (2004) 1.17
Domain structure of phage P4 alpha protein deduced by mutational analysis. J Bacteriol (1995) 1.13
Inhibition of translation and cell growth by minigene expression. J Bacteriol (1999) 1.11
Downstream box-anti-downstream box interactions are dispensable for translation initiation of leaderless mRNAs. EMBO J (1996) 1.11
Expression levels influence ribosomal frameshifting at the tandem rare arginine codons AGG_AGG and AGA_AGA in Escherichia coli. J Bacteriol (2005) 1.00
Structure of the phenylalanyl-tRNA synthetase genes from Thermus thermophilus HB8 and their expression in Escherichia coli. Nucleic Acids Res (1992) 0.95
Optimizing heterologous expression in dictyostelium: importance of 5' codon adaptation. Nucleic Acids Res (2000) 0.95
A single base change in the acceptor stem of tRNA(3Leu) confers resistance upon Escherichia coli to the calmodulin inhibitor, 48/80. EMBO J (1991) 0.94
Highly expressed proteins have an increased frequency of alanine in the second amino acid position. BMC Genomics (2006) 0.93
High level, context dependent misincorporation of lysine for arginine in Saccharomyces cerevisiae a1 homeodomain expressed in Escherichia coli. Protein Sci (1998) 0.92
Expression of precursor and mature carnitine palmitoyltransferase II in Escherichia coli and in vitro: differential behaviour of rat and human isoforms. Biochem J (1993) 0.92
Depletion of free 30S ribosomal subunits in Escherichia coli by expression of RNA containing Shine-Dalgarno-like sequences. J Bacteriol (2002) 0.92
1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism. J Bacteriol (2003) 0.91
The distribution of synonymous codon choice in the translation initiation region of dengue virus. PLoS One (2013) 0.91
Cis control of gene expression in E.coli by ribosome queuing at an inefficient translational stop signal. EMBO J (2002) 0.90
tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes. Nucleic Acids Res (2004) 0.89
Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Res (2007) 0.88
Selection for efficient translation initiation biases codon usage at second amino acid position in secretory proteins. Nucleic Acids Res (2007) 0.87
Mapping of a YscY binding domain within the LcrH chaperone that is required for regulation of Yersinia type III secretion. J Bacteriol (2005) 0.87
Translational features of human alpha 2b interferon production in Escherichia coli. Appl Environ Microbiol (2004) 0.86
tRNA is a new target for cleavage by a MazF toxin. Nucleic Acids Res (2016) 0.85
Efficient expression of gene variants that harbour AGA codons next to the initiation codon. Nucleic Acids Res (2007) 0.84
Quantifying position-dependent codon usage bias. Mol Biol Evol (2014) 0.82
Manipulating the genetic code for membrane protein production: what have we learnt so far? Biochim Biophys Acta (2011) 0.81
A reduced level of charged tRNAArgmnm5UCU triggers the wild-type peptidyl-tRNA to frameshift. RNA (2005) 0.81
Increased functional protein expression using nucleotide sequence features enriched in highly expressed genes in zebrafish. Nucleic Acids Res (2015) 0.80
Cloning and expression of chicken skeletal muscle troponin I in Escherichia coli: the role of rare codons on the expression level. Protein Sci (1993) 0.79
Genetic organization and molecular analysis of the EcoVIII restriction-modification system of Escherichia coli E1585-68 and its comparison with isospecific homologs. Appl Environ Microbiol (2003) 0.78
Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli. Nucleic Acids Res (1992) 0.77
Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants. PLoS One (2012) 0.77
Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus. J Ind Microbiol Biotechnol (2016) 0.76
Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis). Int J Mol Med (2015) 0.76
Incorporation of a tag helps to overcome expression variability in a recombinant host. Biotechnol Rep (Amst) (2016) 0.75
Minigene-like inhibition of protein synthesis mediated by hungry codons near the start codon. Nucleic Acids Res (2008) 0.75
Mapping codon usage of the translation initiation region in porcine reproductive and respiratory syndrome virus genome. Virol J (2011) 0.75
An Engineered Rare Codon Device for Optimization of Metabolic Pathways. Sci Rep (2016) 0.75
Codon Clarity or Conundrum? Cell Syst (2017) 0.75
The importance of arginine codons AGA and AGG for the expression in E. coli of triosephosphate isomerase from seven different species. Biotechnol Rep (Amst) (2017) 0.75
Genome-wide effects of selenium and translational uncoupling on transcription in the termite gut symbiont Treponema primitia. MBio (2013) 0.75
Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli. Proc Natl Acad Sci U S A (2016) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene (1982) 102.30
Processing of adenovirus 2-induced proteins. J Virol (1973) 12.52
Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes. J Mol Biol (1981) 11.87
Nucleotide sequence of the ribosomal protein gene cluster adjacent to the gene for RNA polymerase subunit beta in Escherichia coli. Proc Natl Acad Sci U S A (1979) 9.28
Sequence of the lacZ gene of Escherichia coli. EMBO J (1983) 6.46
Codon usage in regulatory genes in Escherichia coli does not reflect selection for 'rare' codons. Nucleic Acids Res (1986) 5.68
Codon usage determines translation rate in Escherichia coli. J Mol Biol (1989) 5.07
Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res (1986) 4.83
Codon usage can affect efficiency of translation of genes in Escherichia coli. Nucleic Acids Res (1984) 4.51
DNA sequence of the gene for the outer membrane lipoprotein of E. coli: an extremely AT-rich promoter. Cell (1979) 4.31
Codon usage and gene expression. Nucleic Acids Res (1986) 3.19
Feedback regulation of ribosomal protein gene expression in Escherichia coli: structural homology of ribosomal RNA and ribosomal protein MRNA. Proc Natl Acad Sci U S A (1980) 3.11
Messenger ribonucleic acid of the lipoprotein of the Escherichia coli outer membrane. II. The complete nucleotide sequence. J Biol Chem (1980) 2.57
Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism. J Theor Biol (1986) 2.57
The E. coli dnaY gene encodes an arginine transfer RNA. Cell (1986) 2.11
Codon replacement in the PGK1 gene of Saccharomyces cerevisiae: experimental approach to study the role of biased codon usage in gene expression. Mol Cell Biol (1987) 2.06
Identification of the DNA-binding domain of the OmpR protein required for transcriptional activation of the ompF and ompC genes of Escherichia coli by in vivo DNA footprinting. J Biol Chem (1989) 2.01
Up-promoter mutations in the lpp gene of Escherichia coli. Nucleic Acids Res (1985) 1.99
Translation of the sequence AGG-AGG yields 50% ribosomal frameshift. Proc Natl Acad Sci U S A (1988) 1.99
Roles of the 5' leader region of the ompA mRNA. J Mol Biol (1984) 1.33
Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday. Cold Spring Harb Symp Quant Biol (1966) 14.57
A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA). Proc Natl Acad Sci U S A (1984) 8.67
A mutation which changes a membrane protein of E. coli. Proc Natl Acad Sci U S A (1969) 8.23
The outer membrane proteins of Gram-negative bacteria: biosynthesis, assembly, and functions. Annu Rev Biochem (1978) 7.96
Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli. J Bacteriol (1990) 7.07
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet (2008) 7.05
Amino acid sequence for the peptide extension on the prolipoprotein of the Escherichia coli outer membrane. Proc Natl Acad Sci U S A (1977) 6.22
Secretion and membrane localization of proteins in Escherichia coli. CRC Crit Rev Biochem (1980) 5.57
The role of antisense RNA in gene regulation. Annu Rev Biochem (1986) 4.90
Major cold shock protein of Escherichia coli. Proc Natl Acad Sci U S A (1990) 4.90
The assembly of a structural lipoprotein in the envelope of Escherichia coli. J Biol Chem (1972) 4.74
Biosynthesis and self-assembly of protein S, a development-specific protein of Myxococcus xanthus. Proc Natl Acad Sci U S A (1979) 4.58
A comparative study on the genes for three porins of the Escherichia coli outer membrane. DNA sequence of the osmoregulated ompC gene. J Biol Chem (1983) 4.42
DNA sequence of the gene for the outer membrane lipoprotein of E. coli: an extremely AT-rich promoter. Cell (1979) 4.31
GHKL, an emergent ATPase/kinase superfamily. Trends Biochem Sci (2000) 4.20
Homogeneity of envelope proteins of Escherichia coli separated by gel electrophoresis in sodium dodecyl sulfate. J Bacteriol (1973) 4.03
A single amino acid determinant of the membrane localization of lipoproteins in E. coli. Cell (1988) 4.03
Gene expression during development of Myxococcus xanthus: pattern of protein synthesis. Dev Biol (1979) 4.02
CspA, the major cold-shock protein of Escherichia coli, is an RNA chaperone. J Biol Chem (1997) 3.98
Osmoregulation of gene expression. I. DNA sequence of the ompR gene of the ompB operon of Escherichia coli and characterization of its gene product. J Biol Chem (1982) 3.89
Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability. Nucleic Acids Res (1990) 3.79
Changes of membrane proteins and their relation to deoxyribonucleic acid synthesis and cell division of Escherichia coli. J Biol Chem (1970) 3.76
Primary characterization of the protein products of the Escherichia coli ompB locus: structure and regulation of synthesis of the OmpR and EnvZ proteins. J Bacteriol (1985) 3.68
Differential inhibitory effects of antibiotics on the biosynthesis of envelope proteins of Escherichia coli. J Mol Biol (1973) 3.49
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane. Proc Natl Acad Sci U S A (1982) 3.44
The cold-shock response--a hot topic. Mol Microbiol (1994) 3.24
Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli. Proc Natl Acad Sci U S A (1989) 3.19
Osmoregulation of gene expression. II. DNA sequence of the envZ gene of the ompB operon of Escherichia coli and characterization of its gene product. J Biol Chem (1982) 3.15
The use of RNAs complementary to specific mRNAs to regulate the expression of individual bacterial genes. Cell (1984) 3.15
Pleiotropic effect of the rec A gene of Escherichia coli: uncoupling of cell division from deoxyribonucleic acid replication. J Bacteriol (1971) 3.12
A three-dimensional molecular assembly model of a lipoprotein from the Escherichia coli outer membrane. Proc Natl Acad Sci U S A (1974) 3.09
Localization and membrane topology of EnvZ, a protein involved in osmoregulation of OmpF and OmpC in Escherichia coli. J Biol Chem (1987) 2.92
Crystal structure of CspA, the major cold shock protein of Escherichia coli. Proc Natl Acad Sci U S A (1994) 2.89
Precursors of major outer membrane proteins of Escherichia coli. Biochem Biophys Res Commun (1977) 2.79
Association of a retroelement with a P4-like cryptic prophage (retronphage phi R73) integrated into the selenocystyl tRNA gene of Escherichia coli. J Bacteriol (1991) 2.77
Internal standards for molecular weight determinations of proteins by polyacrylamide gel electrophoresis. Applications to envelope proteins of Escherichia coli. J Biol Chem (1971) 2.76
Environmentally regulated gene expression for membrane proteins in Escherichia coli. Annu Rev Cell Biol (1988) 2.73
Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ. Nat Struct Biol (1999) 2.72
NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ. Nature (1998) 2.69
Construction of versatile expression cloning vehicles using the lipoprotein gene of Escherichia coli. EMBO J (1982) 2.68
A family of small repeated elements with some transposon-like properties in the genome of Neisseria gonorrhoeae. J Biol Chem (1988) 2.68
Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli. J Biol Chem (1983) 2.66
Unlinking of cell division from deoxyribonucleic acid replication in a temperature-sensitive deoxyribonucleic acid synthesis mutant of Escherichia coli. J Bacteriol (1969) 2.63
Secretion cloning vectors in Escherichia coli. EMBO J (1984) 2.58
Messenger ribonucleic acid of the lipoprotein of the Escherichia coli outer membrane. II. The complete nucleotide sequence. J Biol Chem (1980) 2.57
Cold shock induces a major ribosomal-associated protein that unwinds double-stranded RNA in Escherichia coli. Proc Natl Acad Sci U S A (1996) 2.55
Lipoprotein from the outer membrane of Escherichia coli: purification, paracrystallization, and some properties of its free form. J Bacteriol (1976) 2.52
A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium. Cell (1991) 2.51
The CspA family in Escherichia coli: multiple gene duplication for stress adaptation. Mol Microbiol (1998) 2.50
Purification of bacteriophage T4 lysozyme. J Biol Chem (1968) 2.47
Histidine kinases: diversity of domain organization. Mol Microbiol (1999) 2.47
Escherichia coli CspA-family RNA chaperones are transcription antiterminators. Proc Natl Acad Sci U S A (2000) 2.46
Regulatory region of the gene for the ompA protein, a major outer membrane protein of Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.44
Intermolecular complementation between two defective mutant signal-transducing receptors of Escherichia coli. Proc Natl Acad Sci U S A (1991) 2.44
Interaction of a transcriptional activator, OmpR, with reciprocally osmoregulated genes, ompF and ompC, of Escherichia coli. J Biol Chem (1986) 2.41
Cold shock and adaptation. Bioessays (1998) 2.39
Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process. Nature (1989) 2.33
A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins. Proc Natl Acad Sci U S A (1986) 2.32
Activation of bacterial porin gene expression by a chimeric signal transducer in response to aspartate. Science (1989) 2.32
Cell-free synthesis of a specific lipoprotein of the Escherichia coli outer membrane directed by purified messenger RNA. Proc Natl Acad Sci U S A (1974) 2.30
Synthetic ColE1 plasmids carrying genes for cell division in Escherichia coli. Plasmid (1977) 2.22
Two forms of a structural lipoprotein in the envelope of Escherichia coli. Further characterization of the free form. J Biol Chem (1973) 2.21
Amino acid sequence of the signal peptide of ompA protein, a major outer membrane protein of Escherichia coli. J Biol Chem (1980) 2.20
Solution NMR structure of the major cold shock protein (CspA) from Escherichia coli: identification of a binding epitope for DNA. Proc Natl Acad Sci U S A (1994) 2.20
Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteins. Mol Microbiol (1994) 2.15
Translocation and assembly of outer membrance proteins of Escherichia coli. Selective accumulation of precursors and novel assembly intermediates caused by phenethyl alcohol. J Mol Biol (1979) 2.15
Use of a lac promoter-operator fragment as a transcriptional control switch for expression of the constitutive lpp gene in Escherichia coli. J Mol Appl Genet (1982) 2.15
DNA sequence of the Serratia marcescens lipoprotein gene. Proc Natl Acad Sci U S A (1980) 2.14
Molecular basis of a mutational hot spot in the lysozyme gene of bacteriophage T4. Nature (1972) 2.08
Further improvements on the phosphotriester synthesis of deoxyribooligonucleotides and the oligonucleotide directed site-specific mutagenesis of E. coli lipoprotein gene. Nucleic Acids Res (1983) 2.05
Two-domain reconstitution of a functional protein histidine kinase. Proc Natl Acad Sci U S A (1998) 2.03
Reverse transcriptase associated with the biosynthesis of the branched RNA-linked msDNA in Myxococcus xanthus. Cell (1989) 2.01
Identification of the DNA-binding domain of the OmpR protein required for transcriptional activation of the ompF and ompC genes of Escherichia coli by in vivo DNA footprinting. J Biol Chem (1989) 2.01
Retronphage phi R73: an E. coli phage that contains a retroelement and integrates into a tRNA gene. Science (1991) 2.00
Positive-negative KG cassettes for construction of multi-gene deletions using a single drug marker. Gene (1996) 2.00
Up-promoter mutations in the lpp gene of Escherichia coli. Nucleic Acids Res (1985) 1.99
The OmpR protein of Escherichia coli binds to sites in the ompF promoter region in a hierarchical manner determined by its degree of phosphorylation. J Biol Chem (1994) 1.99
Structural similarities between the development-specific protein S from a gram-negative bacterium, Myxococcus xanthus, and calmodulin. Proc Natl Acad Sci U S A (1983) 1.97
Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene. J Biol Chem (1985) 1.96
Specific biosynthesis of an envelope protein of Escherichia coli. Nature (1973) 1.96
Signal transduction via the histidyl-aspartyl phosphorelay. Genes Cells (1997) 1.96
The function of micF RNA. micF RNA is a major factor in the thermal regulation of OmpF protein in Escherichia coli. J Biol Chem (1989) 1.96
Interaction of cAMP receptor protein with the ompA gene, a gene for a major outer membrane protein of Escherichia coli. FEBS Lett (1981) 1.94
Requirement of pro-sequence for the production of active subtilisin E in Escherichia coli. J Biol Chem (1987) 1.94
Bacteriophage T7 lysozyme is an N-acetylmuramyl-L-alanine amidase. J Biol Chem (1973) 1.92
In vivo phosphorylation of OmpR, the transcription activator of the ompF and ompC genes in Escherichia coli. J Bacteriol (1990) 1.90
The gene for nucleoside diphosphate kinase functions as a mutator gene in Escherichia coli. J Mol Biol (1995) 1.90
Reverse transcriptase in a clinical strain of Escherichia coli: production of branched RNA-linked msDNA. Science (1989) 1.89
A 26-base-pair repetitive sequence specific for Neisseria gonorrhoeae and Neisseria meningitidis genomic DNA. J Bacteriol (1986) 1.88
Identification of the promoter region of the Escherichia coli major cold shock gene, cspA. J Bacteriol (1992) 1.85
Puromycin-resistant biosynthesis of a specific outer-membrane lipoprotein of Escherichia coli. J Bacteriol (1976) 1.85
A novel immune system against bacteriophage infection using complementary RNA (micRNA). Nature (1985) 1.85
Tandem binding of six OmpR proteins to the ompF upstream regulatory sequence of Escherichia coli. J Biol Chem (1995) 1.85
Overexpression, solubilization and refolding of a genetically engineered derivative of the penicillin-binding protein 3 of Escherichia coli K12. Mol Microbiol (1988) 1.84
Cold-shock response and cold-shock proteins. Curr Opin Microbiol (1999) 1.84
Reexamination of the genome size of myxobacteria, including the use of a new method for genome size analysis. J Bacteriol (1981) 1.83
Change of a sequence of amino acids in phage T4 lysozyme by acridine-induced mutations. Proc Natl Acad Sci U S A (1966) 1.82
Interaction between two major outer membrane proteins of Escherichia coli: the matrix protein and the lipoprotein. J Bacteriol (1978) 1.82
RbfA, a 30S ribosomal binding factor, is a cold-shock protein whose absence triggers the cold-shock response. Mol Microbiol (1996) 1.81
Homology of the gene coding for outer membrane lipoprotein within various Gram-negative bacteria. J Bacteriol (1979) 1.78