IL-17- and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMID 21098230)

Published in J Immunol on November 22, 2010

Authors

Marianna Esposito1, Francesca Ruffini, Alessandra Bergami, Livia Garzetti, Giovanna Borsellino, Luca Battistini, Gianvito Martino, Roberto Furlan

Author Affiliations

1: Clinical Neuroimmunology Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.

Articles citing this

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52

Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure. Am J Transplant (2011) 1.30

Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticity. PLoS One (2011) 1.21

Physiologic control of the functional status of Foxp3+ regulatory T cells. J Immunol (2011) 1.05

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol (2015) 1.00

Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency. Mucosal Immunol (2015) 0.99

Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis. Br J Pharmacol (2013) 0.95

Insufficient interleukin-12 signalling favours differentiation of human CD4(+) and CD8(+) T cells into GATA-3(+) and GATA-3(+) T-bet(+) subsets in humanized mice. Immunology (2014) 0.95

The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome. Haematologica (2012) 0.89

Regulatory T cells in HIV infection: can immunotherapy regulate the regulator? Clin Dev Immunol (2012) 0.85

Mast cell-derived serine proteinase regulates T helper 2 polarization. Sci Rep (2014) 0.84

IFNγ+ Treg in-vivo and in-vitro represent both activated nTreg and peripherally induced aTreg and remain phenotypically stable in-vitro after removal of the stimulus. BMC Immunol (2015) 0.83

Th17 plasticity and its changes associated with inflammatory bowel disease. World J Gastroenterol (2015) 0.82

IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination. J Immunol (2014) 0.82

Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Front Immunol (2015) 0.80

The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. J Immunol (2014) 0.78

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo. J Neuroinflammation (2016) 0.77

Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers. Cell Immunol (2013) 0.76

Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses. PLoS One (2016) 0.75

B-Cell Depletion with CD20 Antibodies as New Approach in the Treatment of Inflammatory and Immunological Events Associated with Spinal Cord Injury. Neurotherapeutics (2016) 0.75

Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response. Biochem Biophys Rep (2017) 0.75

Crossover Subsets of CD4(+) T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn's Disease and Ulcerative Colitis. Dig Dis Sci (2017) 0.75

Articles by these authors

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 6.03

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature (2003) 5.31

Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci (2005) 3.77

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med (2009) 3.68

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature (2005) 3.53

Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med (2005) 3.13

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.99

CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset. Blood (2004) 2.80

Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res (2005) 2.32

Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res (2007) 2.08

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain (2009) 1.89

Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci U S A (2004) 1.79

Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J (2009) 1.78

Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines. FASEB J (2007) 1.76

Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain (2008) 1.67

Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J Neurosci (2009) 1.59

Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat Neurosci (2012) 1.55

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol (2003) 1.55

CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis. Brain (2011) 1.53

Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol (2010) 1.53

Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A (2006) 1.50

Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light. Brain (2013) 1.50

Reversible senescence in human CD4+CD45RA+CD27- memory T cells. J Immunol (2011) 1.46

Lack of CD27-CD45RA-V gamma 9V delta 2+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis. J Immunol (2002) 1.46

Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol (2006) 1.40

Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS One (2010) 1.36

Microglia and multiple sclerosis. J Neurosci Res (2005) 1.34

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology (2011) 1.34

Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci (2007) 1.31

Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol (2009) 1.30

CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood (2003) 1.29

CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Blood (2008) 1.29

Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells (2007) 1.27

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain (2013) 1.27

FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways. Blood (2004) 1.27

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol (2012) 1.26

Retracted Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies. Mult Scler Int (2011) 1.26

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain (2012) 1.26

Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma. Eur J Immunol (2003) 1.25

Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage. J Neurosci (2011) 1.24

Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cells. Stem Cells (2009) 1.22

Identification and enrichment of spermatogonial stem cells displaying side-population phenotype in immature mouse testis. FASEB J (2003) 1.22

Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One (2009) 1.21

Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection. Curr Opin Neurol (2012) 1.21

CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. J Immunol (2006) 1.19

An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis. Proc Natl Acad Sci U S A (2005) 1.19

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons. Development (2013) 1.18

Animal models of multiple sclerosis. Methods Mol Biol (2009) 1.17

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Mol Med (2013) 1.16

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain (2003) 1.15

Microglial microvesicle secretion and intercellular signaling. Front Physiol (2012) 1.12

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis. J Neuroimmunol (2004) 1.09

CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Blood (2007) 1.09

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J Neuroimmunol (2010) 1.08

Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev (2005) 1.08

Multifaceted aspects of inflammation in multiple sclerosis: the role of microglia. J Neuroimmunol (2007) 1.07

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF. Nat Commun (2013) 1.06

Regeneration and repair in multiple sclerosis: the role of cell transplantation. Neurosci Lett (2009) 1.06

P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability. Cell Immunol (2007) 1.06

The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci (2005) 1.06

Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis. Ann Neurol (2012) 1.05