Published in PLoS One on November 16, 2010
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci (2013) 0.97
MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination. Nat Commun (2013) 0.90
Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome. PLoS One (2011) 0.90
The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet (2013) 0.87
TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. EMBO Mol Med (2015) 0.82
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells. PLoS One (2012) 0.82
The role of histone ubiquitination during spermatogenesis. Biomed Res Int (2014) 0.79
Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays. J Biol Chem (2016) 0.77
Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Mol Cancer (2017) 0.75
Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes. PLoS Genet (2017) 0.75
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An abundance of X-linked genes expressed in spermatogonia. Nat Genet (2001) 5.87
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome. Nat Genet (1999) 4.56
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol (2003) 3.56
An essential role of N-terminal arginylation in cardiovascular development. Science (2002) 3.06
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability. Nature (2001) 3.04
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature (2005) 2.55
Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes Dev (2005) 2.38
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Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse. Hum Mol Genet (2005) 2.12
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The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J (1998) 1.71
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Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol (2006) 1.60
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum Mol Genet (2004) 1.56
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases. Hum Mol Genet (2003) 1.55
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Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role. Mol Cell (2006) 1.27
Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice. PLoS Genet (2008) 1.23
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A (2010) 1.17
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Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res (2012) 4.80
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev (2002) 3.52
An essential role of N-terminal arginylation in cardiovascular development. Science (2002) 3.06
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell (2009) 3.05
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol (2005) 2.57
Oct4 is required for primordial germ cell survival. EMBO Rep (2004) 2.56
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The mammalian N-end rule pathway: new insights into its components and physiological roles. Trends Biochem Sci (2007) 2.28
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol (2012) 2.14
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet (2005) 2.04
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Developmental changes in histone macroH2A1-mediated gene regulation. Mol Cell Biol (2007) 1.77
Primary sequence and epigenetic determinants of in vivo occupancy of genomic DNA by GATA1. Nucleic Acids Res (2009) 1.76
Finding cis-regulatory elements using comparative genomics: some lessons from ENCODE data. Genome Res (2007) 1.75
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell (2012) 1.74
Experimental validation of predicted mammalian erythroid cis-regulatory modules. Genome Res (2006) 1.71
Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol (2003) 1.68
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest (2010) 1.66
The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse. BMC Dev Biol (2009) 1.66
Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy. J Mol Cell Cardiol (2012) 1.64
The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nat Rev Mol Cell Biol (2011) 1.62
Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol (2006) 1.60
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum Mol Genet (2004) 1.56
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc Natl Acad Sci U S A (2011) 1.56
Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes. Proc Natl Acad Sci U S A (2013) 1.54
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A (2010) 1.52
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun (2013) 1.39
Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc Natl Acad Sci U S A (2006) 1.37
Meiotic failure in male mice lacking an X-linked factor. Genes Dev (2008) 1.33
Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development (2008) 1.32
The substrate recognition domains of the N-end rule pathway. J Biol Chem (2008) 1.31
Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol (2007) 1.30
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. J Biol Chem (2006) 1.30
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. J Biol Chem (2006) 1.26
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal (2013) 1.24
MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol (2012) 1.23
Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development. Development (2008) 1.22
Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem (2009) 1.21
Hematopoietic reconstitution with androgenetic and gynogenetic stem cells. Genes Dev (2007) 1.19
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A (2010) 1.17
The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells. Stem Cells (2005) 1.17
Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. J Biol Chem (2007) 1.16
Endoscopic third ventriculostomy in the management of obstructive hydrocephalus: an outcome analysis. J Neurosurg (2004) 1.16
Arginylation-dependent neural crest cell migration is essential for mouse development. PLoS Genet (2010) 1.16
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Mol Cell Biol (2009) 1.13
Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia. Dev Biol (2009) 1.09
Clinically failed eggs as a source of normal human embryo stem cells. Stem Cell Res (2009) 1.09
The clinical and radiographic characteristics of condylar osteochondroma. Oral Surg Oral Med Oral Pathol Oral Radiol (2012) 1.06
The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation. Mol Cell Biol (2011) 1.05
Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin. J Neurochem (2012) 1.05
Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc Natl Acad Sci U S A (2007) 1.03
Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem (2005) 1.03
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc Natl Acad Sci U S A (2013) 1.01
Regulation of male fertility by X-linked genes. J Androl (2009) 1.01
Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem (2010) 1.00
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nucleic Acids Res (2011) 0.99
Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation? EMBO J (2003) 0.99
Pluripotent lineage definition in bovine embryos by Oct4 transcript localization. Biol Reprod (2004) 0.99
Robotic versus laparoscopic total mesorectal excision for rectal cancer: a meta-analysis of eight studies. J Gastrointest Surg (2014) 0.99
Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood (2011) 0.98
Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast. Cell Signal (2012) 0.97
Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol (2008) 0.96
Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease. J Pineal Res (2004) 0.96
Quercetin-induced ubiquitination and down-regulation of Her-2/neu. J Cell Biochem (2008) 0.96
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance. Cell Signal (2010) 0.94