Published in Mol Cell on November 25, 2009
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev (2010) 2.93
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity (2011) 2.53
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood (2011) 2.42
GATA switches as developmental drivers. J Biol Chem (2010) 2.32
GATA-1 directly regulates p21 gene expression during erythroid differentiation. Cell Cycle (2010) 2.17
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood (2013) 2.12
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic Acids Res (2012) 2.11
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res (2010) 2.02
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1. Genome Res (2011) 2.00
Integrating one-dimensional and three-dimensional maps of genomes. J Cell Sci (2010) 1.92
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biol (2012) 1.88
Absence of a simple code: how transcription factors read the genome. Trends Biochem Sci (2014) 1.84
Chromatin landscape dictates HSF binding to target DNA elements. PLoS Genet (2010) 1.82
Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements. Genome Res (2011) 1.80
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev (2014) 1.71
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet (2011) 1.69
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Dev Cell (2012) 1.63
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol (2010) 1.58
Inferring transcription factor complexes from ChIP-seq data. Nucleic Acids Res (2011) 1.53
Functions of BET proteins in erythroid gene expression. Blood (2015) 1.50
Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation. Blood (2011) 1.50
Networking erythropoiesis. J Exp Med (2010) 1.47
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal (2015) 1.44
Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood (2011) 1.43
Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs. Genome Biol (2013) 1.41
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J (2011) 1.41
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood (2010) 1.40
Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res (2012) 1.38
Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities. Blood (2011) 1.36
Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood (2012) 1.35
Multilayered specification of the T-cell lineage fate. Immunol Rev (2010) 1.32
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol (2011) 1.25
Large-scale quality analysis of published ChIP-seq data. G3 (Bethesda) (2014) 1.23
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome Res (2014) 1.19
POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function. Immunol Rev (2012) 1.14
GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood (2012) 1.14
A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet (2010) 1.14
Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J (2011) 1.13
Autophagy driven by a master regulator of hematopoiesis. Mol Cell Biol (2011) 1.13
DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Rep (2012) 1.12
A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation. Proc Natl Acad Sci U S A (2012) 1.12
The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. Dev Cell (2011) 1.11
A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1. PLoS Genet (2011) 1.09
Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function. Hum Mol Genet (2012) 1.08
Context-dependent function of "GATA switch" sites in vivo. Blood (2011) 1.08
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Combinatorial regulation of tissue specification by GATA and FOG factors. Development (2012) 1.06
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica (2015) 1.06
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Development (2013) 1.06
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med (2010) 1.06
Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood (2013) 1.05
Identification of biologically relevant enhancers in human erythroid cells. J Biol Chem (2013) 1.03
Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proc Natl Acad Sci U S A (2014) 1.02
Discovering transcription factor regulatory targets using gene expression and binding data. Bioinformatics (2011) 1.02
Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors. Cell Stem Cell (2013) 1.01
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proc Natl Acad Sci U S A (2011) 1.00
Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS One (2010) 0.99
DECOD: fast and accurate discriminative DNA motif finding. Bioinformatics (2011) 0.98
EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol (2012) 0.98
Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem (2013) 0.98
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol (2011) 0.97
Ldb1 complexes: the new master regulators of erythroid gene transcription. Trends Genet (2013) 0.96
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol (2015) 0.96
Enhancer identification in mouse embryonic stem cells using integrative modeling of chromatin and genomic features. BMC Genomics (2012) 0.96
Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood (2014) 0.95
Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells. Genes Dev (2015) 0.95
Evolution of hemoglobin and its genes. Cold Spring Harb Perspect Med (2012) 0.93
The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Nucleic Acids Res (2014) 0.92
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. Mol Cell Biol (2012) 0.91
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev (2014) 0.91
Role of LRF/Pokemon in lineage fate decisions. Blood (2013) 0.90
The GATA factor revolution in hematology. Blood (2017) 0.90
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements. J Biol Chem (2011) 0.90
The transcriptional programme controlled by Runx1 during early embryonic blood development. Dev Biol (2012) 0.90
Transcriptional mechanisms underlying hemoglobin synthesis. Cold Spring Harb Perspect Med (2013) 0.90
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity. J Biol Chem (2012) 0.88
Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. J Biol Chem (2011) 0.88
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene (2013) 0.87
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. Blood (2012) 0.87
Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1. PLoS One (2012) 0.87
Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J (2015) 0.86
Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc Natl Acad Sci U S A (2013) 0.86
T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem (2012) 0.86
Function of GATA factors in the adult mouse liver. PLoS One (2013) 0.85
Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol (2013) 0.84
The biology of pediatric acute megakaryoblastic leukemia. Blood (2015) 0.84
Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia. Cell Death Differ (2013) 0.84
Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points. Exp Hematol (2014) 0.84
Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome. Neuropsychobiology (2011) 0.83
The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res (2007) 23.13
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (1989) 9.08
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
The erythroid-specific transcription factor Eryf1: a new finger protein. Cell (1989) 6.14
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell (2009) 5.51
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A (1988) 5.29
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A (1996) 5.20
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood (2003) 4.91
Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68
The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev (1988) 4.61
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature (2005) 4.39
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell (1996) 4.35
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A (2003) 4.28
K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev (1997) 4.24
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature (1989) 3.76
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol (2005) 3.74
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
The eed mutation disrupts anterior mesoderm production in mice. Development (1995) 3.17
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science (2007) 2.92
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A (1995) 2.78
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood (1999) 2.62
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell (2007) 2.62
Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood (1999) 2.61
A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data. Bioinformatics (2005) 2.52
GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol (2003) 2.52
A global role for EKLF in definitive and primitive erythropoiesis. Blood (2005) 2.24
Hematopoietic development: a balancing act. Curr Opin Genet Dev (2001) 2.21
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction. Mol Cell Biol (1996) 2.05
Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene. Development (1999) 1.92
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Mol Cell Biol (2005) 1.67
Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif. Genome Res (2008) 1.58
Developmental control via GATA factor interplay at chromatin domains. J Cell Physiol (2005) 1.46
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood (2002) 1.41
Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol (2008) 1.36
The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. J Biol Chem (2001) 1.35
GATA zinc finger interactions modulate DNA binding and transactivation. J Biol Chem (2000) 1.26
Use of protein biotinylation in vivo for chromatin immunoprecipitation. Anal Biochem (2004) 1.24
Metabolic biotinylation of recombinant proteins in mammalian cells and in mice. Mol Ther (2000) 1.16
Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria. Blood (2006) 1.16
Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells. J Exp Med (1997) 1.11
The N-terminal fingers of chicken GATA-2 and GATA-3 are independent sequence-specific DNA binding domains. EMBO J (1997) 1.11
Transcription factor GATA-1 and Down syndrome leukemogenesis. Leuk Lymphoma (2006) 0.88
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Transcriptional regulatory networks in Saccharomyces cerevisiae. Science (2002) 43.52
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66
Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05
Annotation of functional variation in personal genomes using RegulomeDB. Genome Res (2012) 11.47
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics (2006) 11.13
Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet (2007) 10.78
A protein interaction network for pluripotency of embryonic stem cells. Nature (2006) 9.63
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res (2012) 9.13
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet (2006) 7.53
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet (2010) 7.39
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res (2007) 7.05
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet (2007) 6.92
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell (2008) 6.86
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (2008) 6.66
Computational discovery of gene modules and regulatory networks. Nat Biotechnol (2003) 6.55
Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
A critical role for eosinophils in allergic airways remodeling. Science (2004) 5.53
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 5.07
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
Signaling network model of chromatin. Cell (2002) 4.87
Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Res (2012) 4.80
Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene (2002) 4.80
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer (2004) 4.59
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem (2003) 3.93
The placenta is a niche for hematopoietic stem cells. Dev Cell (2005) 3.83
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell (2007) 3.82
Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol (2013) 3.82
ORegAnno: an open-access community-driven resource for regulatory annotation. Nucleic Acids Res (2007) 3.80
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature (2003) 3.77
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
High-resolution computational models of genome binding events. Nat Biotechnol (2006) 3.74
Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity (2003) 3.59
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nat Struct Mol Biol (2006) 3.54
Regulatory potential scores from genome-wide three-way alignments of human, mouse, and rat. Genome Res (2004) 3.53
Developmental and species-divergent globin switching are driven by BCL11A. Nature (2009) 3.49
Epigenetic reprogramming in cancer. Science (2013) 3.47
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell (2003) 3.47
Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A (2014) 3.35
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature (2003) 3.25
Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell (2011) 3.20
Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17
Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell (2011) 3.16
Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol (2006) 3.15
A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A (2008) 3.10
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell (2009) 3.08
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet (2009) 3.06
A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell (2012) 3.04
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. PLoS Genet (2011) 2.98
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev (2010) 2.93
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol (2013) 2.89
GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet (2010) 2.86
The efficacy and safety of pain management before and after implementation of hospital-wide pain management standards: is patient safety compromised by treatment based solely on numerical pain ratings? Anesth Analg (2005) 2.83
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell (2010) 2.80