Published in Antiviral Res on December 01, 2010
Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities. Antiviral Res (2010) 1.15
Clinical evaluation of microbicide formulations. Antiviral Res (2010) 1.05
Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater (2012) 1.05
Polymer nanoparticles encapsulating siRNA for treatment of HSV-2 genital infection. J Control Release (2012) 0.95
Spray drying tenofovir loaded mucoadhesive and pH-sensitive microspheres intended for HIV prevention. Antiviral Res (2012) 0.88
Nanoparticle transport from mouse vagina to adjacent lymph nodes. PLoS One (2012) 0.82
Drug synergy of tenofovir and nanoparticle-based antiretrovirals for HIV prophylaxis. PLoS One (2013) 0.81
The importance of the vaginal delivery route for antiretrovirals in HIV prevention. Ther Deliv (2011) 0.81
Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices. Pharm Res (2012) 0.80
Use of silver nanoparticles increased inhibition of cell-associated HIV-1 infection by neutralizing antibodies developed against HIV-1 envelope proteins. J Nanobiotechnology (2011) 0.80
Nanoparticles containing siRNA to silence CD4 and CCR5 reduce expression of these receptors and inhibit HIV-1 infection in human female reproductive tract tissue explants. Infect Dis Rep (2011) 0.79
Preparation and evaluation of intravaginal ring containing drospirenone. Adv Pharmacol Sci (2013) 0.78
Microbicides for the Treatment of Sexually Transmitted HIV Infections. J Pharm (Cairo) (2014) 0.76
Development and in vitro/in vivo Evaluation of a Silastic Intravaginal Ring for Mifepristone Delivery. Indian J Pharm Sci (2015) 0.75
Pharmacokinetics of the protein microbicide 5P12-RANTES in sheep following single dose vaginal gel administration. Antimicrob Agents Chemother (2017) 0.75
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A (2007) 3.94
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev (2008) 3.41
Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved? Nat Rev Microbiol (2006) 3.13
Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission. Annu Rev Med (2008) 2.81
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med (2008) 2.74
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages. J Virol (2011) 2.55
Micro- and macrorheology of mucus. Adv Drug Deliv Rev (2009) 2.54
Efficient active transport of gene nanocarriers to the cell nucleus. Proc Natl Acad Sci U S A (2003) 2.52
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol (2009) 2.49
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew Chem Int Ed Engl (2008) 2.38
Real-time multiple-particle tracking: applications to drug and gene delivery. Adv Drug Deliv Rev (2005) 2.21
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A (2009) 2.13
Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem (2008) 2.12
Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport. J Biol Chem (2003) 2.01
IFN-gamma at the site of infection determines rate of clearance of infection in cryptococcal meningitis. J Immunol (2005) 2.00
In vitro and in vivo: the story of nonoxynol 9. J Acquir Immune Defic Syndr (2005) 1.99
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A (2009) 1.86
A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med (2012) 1.85
A functional anatomic defect of the cystic fibrosis airway. Am J Respir Crit Care Med (2014) 1.85
Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis. Sex Transm Infect (2010) 1.80
Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci Transl Med (2012) 1.68
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev (2011) 1.65
Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials (2007) 1.59
In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide. BMC Infect Dis (2011) 1.56
The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol (2005) 1.54
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. Biomaterials (2009) 1.54
MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat Mater (2013) 1.53
Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc Natl Acad Sci U S A (2003) 1.48
Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent. J Clin Invest (2002) 1.46
Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PLoS One (2013) 1.43
A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions. Sex Transm Dis (2003) 1.40
Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring. Antimicrob Agents Chemother (2011) 1.38
Altering mucus rheology to "solidify" human mucus at the nanoscale. PLoS One (2009) 1.37
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A (2013) 1.36
Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood) (2007) 1.31
New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials (2002) 1.27
Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model. BMC Infect Dis (2005) 1.26
Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis. Sex Transm Dis (2002) 1.25
Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets. Antiviral Res (2010) 1.24
Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. Angew Chem Int Ed Engl (2011) 1.23
PEGylation of nanoparticles improves their cytoplasmic transport. Int J Nanomedicine (2007) 1.20
Transport of polymeric nanoparticle gene carriers in gastric mucus. Biotechnol Prog (2004) 1.20
Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli. BMC Infect Dis (2010) 1.19
Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharm Res (2010) 1.19
Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking. Biotechnol Prog (2004) 1.19
An intravaginal ring for the simultaneous delivery of multiple drugs. J Pharm Sci (2012) 1.17
A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis. Antimicrob Agents Chemother (2012) 1.16
Nanoparticle diffusion in respiratory mucus from humans without lung disease. Biomaterials (2013) 1.11
Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse. BMC Infect Dis (2010) 1.09
MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques. PLoS Pathog (2012) 1.07
Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release (2007) 1.07
Cellulose acetate 1,2-benzenedicarboxylate inhibits infection by cell-free and cell-associated primary HIV-1 isolates. AIDS Res Hum Retroviruses (2006) 1.06
Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater (2012) 1.05
Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials (2011) 1.04
Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties. AIDS Res Hum Retroviruses (2013) 1.04
Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation. J Control Release (2011) 1.03
Design of tenofovir-UC781 combination microbicide vaginal gels. J Pharm Sci (2012) 1.03
Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs. J Control Release (2004) 1.02
A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781. J Pharm Sci (2011) 1.01
Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine. Nanomedicine (Lond) (2011) 1.01
Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles. Biomaterials (2006) 1.00
Enhanced adhesion of ligand-conjugated biodegradable particles to colitic venules. FASEB J (2005) 1.00
Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients. PLoS One (2011) 0.99
Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure. PLoS One (2011) 0.99
N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles. Mol Ther (2011) 0.98
Evaluation of microbicide gel adherence monitoring methods. Sex Transm Dis (2012) 0.98
Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo. Biomaterials (2009) 0.96
Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Adv Healthc Mater (2013) 0.95
Enhanced vaginal drug delivery through the use of hypotonic formulations that induce fluid uptake. Biomaterials (2013) 0.94
Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. J Virol (2014) 0.94
Brain-penetrating nanoparticles improve paclitaxel efficacy in malignant glioma following local administration. ACS Nano (2014) 0.93
Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus. J Control Release (2013) 0.93
Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung. Pharm Res (2003) 0.92
Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo. J Control Release (2013) 0.92
Sustained delivery of a HIF-1 antagonist for ocular neovascularization. J Control Release (2013) 0.92
Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine. Biomaterials (2011) 0.91
Real-time multiple particle tracking of gene nanocarriers in complex biological environments. Methods Mol Biol (2008) 0.91
Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles. J Control Release (2011) 0.91
Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers. Angew Chem Int Ed Engl (2013) 0.90
Pharmacokinetics and topical vaginal effects of two tenofovir gels in rabbits. AIDS Res Hum Retroviruses (2012) 0.90
A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles. J Control Release (2011) 0.90
Pharmacokinetic and safety analyses of tenofovir and tenofovir-emtricitabine vaginal tablets in pigtailed macaques. Antimicrob Agents Chemother (2014) 0.89
In vitro anti-HIV and -HSV activity and safety of sodium rutin sulfate as a microbicide candidate. Antiviral Res (2007) 0.89
Carnauba wax nanoparticles enhance strong systemic and mucosal cellular and humoral immune responses to HIV-gp140 antigen. Vaccine (2010) 0.88
Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. J Control Release (2012) 0.88
Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis. BJU Int (2006) 0.88
Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir. J Control Release (2012) 0.87
A recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions. Proteins (2007) 0.87
Drug-induced reactivation of apoptosis abrogates HIV-1 infection. PLoS One (2013) 0.87
Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies. Cell Tissue Res (2002) 0.87
Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis. Biotechnol Bioeng (2008) 0.86
Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues. Mol Pharm (2013) 0.86
Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid). Drug Deliv Transl Res (2012) 0.86
Biotargeted nanomedicines for cancer: six tenets before you begin. Nanomedicine (Lond) (2013) 0.85
Formulating a sulfonated antiviral dendrimer in a vaginal microbicidal gel having dual mechanisms of action. Drug Dev Ind Pharm (2009) 0.85
DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4. PLoS One (2011) 0.85
Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma. Neurosurgery (2003) 0.85
Real-time gene delivery vector tracking in the endo-lysosomal pathway of live cells. Microsc Res Tech (2011) 0.83
Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation. J Aerosol Med Pulm Drug Deliv (2012) 0.83