Published in Biotechnol Prog on June 04, 2004
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A (2007) 3.94
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev (2008) 3.41
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A (2009) 1.86
Modulation of Viscoelasticity and HIV Transport as a Function of pH in a Reversibly Crosslinked Hydrogel. Adv Funct Mater (2009) 1.28
Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. J Control Release (2014) 0.90
Quantitative nanoparticle tracking: applications to nanomedicine. Nanomedicine (Lond) (2011) 0.88
Particle tracking in drug and gene delivery research: State-of-the-art applications and methods. Adv Drug Deliv Rev (2015) 0.86
Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung's Disease. Macromol Biosci (2015) 0.85
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS. Biomaterials (2013) 0.83
Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. Int J Nanomedicine (2012) 0.83
Nanoparticle-based drug delivery to the vagina: a review. J Control Release (2014) 0.83
Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier. Biophys J (2013) 0.82
Amoxicillin loaded chitosan-alginate polyelectrolyte complex nanoparticles as mucopenetrating delivery system for h. Pylori. Sci Pharm (2011) 0.82
Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus. Nanotoxicology (2011) 0.82
Disruption of the mucus barrier by topically applied exogenous particles. Mol Pharm (2010) 0.81
An exploration of the microrheological environment around the distal ileal villi and proximal colonic mucosa of the possum (Trichosurus vulpecula). J R Soc Interface (2013) 0.80
The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery systems. Int J Nanomedicine (2007) 0.79
Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion. Biophys J (2015) 0.77
Food-associated stimuli enhance barrier properties of gastrointestinal mucus. Biomaterials (2015) 0.77
Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation. J Control Release (2015) 0.77
Responsive foams for nanoparticle delivery. Colloids Surf B Biointerfaces (2015) 0.75
Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. J Control Release (2016) 0.75
Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery. ACS Macro Lett (2016) 0.75
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A (2007) 3.94
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev (2008) 3.41
A perinuclear actin cap regulates nuclear shape. Proc Natl Acad Sci U S A (2009) 3.12
Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol (2005) 2.89
Micromechanical mapping of live cells by multiple-particle-tracking microrheology. Biophys J (2002) 2.63
Micro- and macrorheology of mucus. Adv Drug Deliv Rev (2009) 2.54
Efficient active transport of gene nanocarriers to the cell nucleus. Proc Natl Acad Sci U S A (2003) 2.52
Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp Cell Res (2008) 2.52
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J (2007) 2.51
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol (2009) 2.49
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew Chem Int Ed Engl (2008) 2.38
Real-time multiple-particle tracking: applications to drug and gene delivery. Adv Drug Deliv Rev (2005) 2.21
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A (2011) 2.17
Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking. J Cell Sci (2004) 2.17
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A (2009) 2.13
Intracellular mechanics of migrating fibroblasts. Mol Biol Cell (2004) 2.06
MinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZ. Curr Biol (2008) 2.02
Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport. J Biol Chem (2003) 2.01
Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. Biophys J (2008) 1.99
Single molecule characterization of P-selectin/ligand binding. J Biol Chem (2003) 1.96
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophys J (2008) 1.92
Mechanics and dynamics of actin-driven thin membrane protrusions. Biophys J (2005) 1.91
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A (2009) 1.86
A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med (2012) 1.85
A functional anatomic defect of the cystic fibrosis airway. Am J Respir Crit Care Med (2014) 1.85
Structure of the actin crosslinking core of fimbrin. Structure (2004) 1.82
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev (2008) 1.81
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem (2009) 1.73
The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks. J Biol Chem (2003) 1.70
Single-molecule analysis of cadherin-mediated cell-cell adhesion. J Cell Sci (2006) 1.70
Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci Transl Med (2012) 1.68
The assembly of MreB, a prokaryotic homolog of actin. J Biol Chem (2004) 1.67
Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos. Biophys J (2006) 1.66
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev (2011) 1.65
Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci (2006) 1.60
Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials (2007) 1.59
Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation. Mol Biol Cell (2004) 1.57
Distinct kinetic and mechanical properties govern selectin-leukocyte interactions. J Cell Sci (2004) 1.54
The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. Biomaterials (2009) 1.54
MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat Mater (2013) 1.53
Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res (2013) 1.51
Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells. Biophys J (2005) 1.50
Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo. Proc Natl Acad Sci U S A (2003) 1.48
Towards a regional approach to cell mechanics. Trends Cell Biol (2004) 1.46
Condensation of FtsZ filaments can drive bacterial cell division. Proc Natl Acad Sci U S A (2008) 1.46
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem (2013) 1.44
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. J Cell Biol (2003) 1.44
Mechanics of enveloped virus entry into host cells. Biophys J (2005) 1.40
Magnetic tweezers measurement of single molecule torque. Nano Lett (2009) 1.40
Focal adhesion size uniquely predicts cell migration. FASEB J (2012) 1.40
Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophys J (2006) 1.39
Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell (2004) 1.39
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res (2013) 1.38
Altering mucus rheology to "solidify" human mucus at the nanoscale. PLoS One (2009) 1.37
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A (2013) 1.36
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Sci Rep (2012) 1.36
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Receptor-ligand binding: 'catch' bonds finally caught. Curr Biol (2003) 1.32
Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood) (2007) 1.31
{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A (2008) 1.31
Three-dimensional cell migration does not follow a random walk. Proc Natl Acad Sci U S A (2014) 1.30
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells. J Virol (2005) 1.28
New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials (2002) 1.27
GTPase activity, structure, and mechanical properties of filaments assembled from bacterial cytoskeleton protein MreB. J Bacteriol (2006) 1.24
Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. Angew Chem Int Ed Engl (2011) 1.23
PEGylation of nanoparticles improves their cytoplasmic transport. Int J Nanomedicine (2007) 1.20
Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Methods Cell Biol (2007) 1.19
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A (2013) 1.19
Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking. Biotechnol Prog (2004) 1.19
Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments. Mol Biol Cell (2002) 1.17
Cross-linking FtsZ polymers into coherent Z rings. Mol Microbiol (2010) 1.17
High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Anal Chem (2013) 1.16
Programmed subcellular release for studying the dynamics of cell detachment. Nat Methods (2009) 1.15
Polymerization and bundling kinetics of FtsZ filaments. Biophys J (2008) 1.14
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Sci Rep (2013) 1.13
How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochem Biophys Res Commun (2005) 1.13
Resolving the role of actoymyosin contractility in cell microrheology. PLoS One (2009) 1.13
A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin. J Biol Chem (2006) 1.12
Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina. J Biol Chem (2004) 1.12
Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool. Protein Eng Des Sel (2013) 1.11
The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities. J Struct Biol (2003) 1.11
Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion. J Cell Biol (2009) 1.11
Nanoparticle diffusion in respiratory mucus from humans without lung disease. Biomaterials (2013) 1.11
The perinuclear actin cap in health and disease. Nucleus (2010) 1.09
The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. PLoS One (2012) 1.09
Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis. FASEB J (2012) 1.07
Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release (2007) 1.07
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. FASEB J (2013) 1.07
Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. MAbs (2015) 1.06
Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery. Adv Mater (2012) 1.05
Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials (2011) 1.04