Published in Mol Biol Evol on November 25, 2010
Ethical alternatives to experiments with novel potential pandemic pathogens. PLoS Med (2014) 1.68
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models. Genetics (2011) 1.45
Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proc Natl Acad Sci U S A (2013) 1.34
Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol (2011) 1.28
On the statistical interpretation of site-specific variables in phylogeny-based substitution models. Genetics (2012) 1.00
Bayesian molecular clock dating of species divergences in the genomics era. Nat Rev Genet (2015) 0.95
Pathogen-host-environment interplay and disease emergence. Emerg Microbes Infect (2013) 0.95
Cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. J Virol (2012) 0.87
Components of selection in the evolution of the influenza virus: linkage effects beat inherent selection. PLoS Pathog (2012) 0.80
The tangled bank of amino acids. Protein Sci (2016) 0.76
Phylodynamics of the emergence of influenza viruses after cross-species transmission. PLoS One (2013) 0.75
Genotyping and detection of common avian and human origin-influenza viruses using a portable chemiluminescence imaging microarray. Springerplus (2016) 0.75
Finding Direction in the Search for Selection. J Mol Evol (2016) 0.75
MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res (2004) 168.89
A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol (2003) 102.57
Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. J Mol Evol (1985) 47.78
PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol (2007) 45.68
PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci (1997) 45.07
Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med (2009) 42.75
Evolution and ecology of influenza A viruses. Microbiol Rev (1992) 39.99
Pandemic potential of a strain of influenza A (H1N1): early findings. Science (2009) 26.24
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature (2009) 17.96
Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep (2009) 17.76
A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol Biol Evol (2001) 16.83
Characterization of the 1918 influenza virus polymerase genes. Nature (2005) 15.73
1918 Influenza: the mother of all pandemics. Emerg Infect Dis (2006) 12.11
Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med (2002) 11.85
The influenza virus resource at the National Center for Biotechnology Information. J Virol (2007) 11.33
Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol (1989) 10.63
A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol (1993) 10.22
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments. Nucleic Acids Res (2006) 8.36
Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature (1983) 8.28
Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals. J Virol (2000) 8.28
Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology (1994) 8.06
Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol (1999) 7.72
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog (2009) 6.09
Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature (1978) 5.43
Influenza: old and new threats. Nat Med (2004) 5.35
Comparison of complete amino acid sequences and receptor-binding properties among 13 serotypes of hemagglutinins of influenza A viruses. Virology (1991) 4.85
Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A (2009) 4.36
Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man. Bull World Health Organ (1981) 4.20
Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathog (2010) 3.65
Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir. Virology (1993) 3.54
Genomic signatures of human versus avian influenza A viruses. Emerg Infect Dis (2006) 3.51
The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J Virol (1998) 3.25
Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol (2004) 3.19
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog (2008) 2.60
A fast algorithm for joint reconstruction of ancestral amino acid sequences. Mol Biol Evol (2000) 2.59
Persistent host markers in pandemic and H5N1 influenza viruses. J Virol (2007) 2.42
Host restriction of avian influenza viruses at the level of the ribonucleoproteins. Annu Rev Microbiol (2008) 2.29
Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage. Mol Biol Evol (2008) 2.25
The origin and virulence of the 1918 "Spanish" influenza virus. Proc Am Philos Soc (2006) 1.96
Identifying changes in selective constraints: host shifts in influenza. PLoS Comput Biol (2009) 1.67
Assessing the accuracy of ancestral protein reconstruction methods. PLoS Comput Biol (2006) 1.62
Changing selective pressure during antigenic changes in human influenza H3. PLoS Pathog (2008) 1.61
Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis. BMC Bioinformatics (2008) 1.61
Probabilistic reconstruction of ancestral protein sequences. J Mol Evol (1996) 1.51
Towards an atomic resolution understanding of the influenza virus replication machinery. Curr Opin Struct Biol (2010) 1.49
Molecular virology: was the 1918 pandemic caused by a bird flu? Nature (2006) 1.46
Molecular virology: was the 1918 flu avian in origin? Nature (2006) 1.46
Using non-homogeneous models of nucleotide substitution to identify host shift events: application to the origin of the 1918 'Spanish' influenza pandemic virus. J Mol Evol (2009) 1.11
A codon-based model of host-specific selection in parasites, with an application to the influenza A virus. Mol Biol Evol (2003) 1.06
The global circulation of seasonal influenza A (H3N2) viruses. Science (2008) 10.05
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature (2006) 6.00
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature (2008) 3.79
Why are proteins marginally stable? Proteins (2002) 2.74
Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses. Vaccine (2008) 2.56
Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin. Proc Natl Acad Sci U S A (2012) 2.18
rtREV: an amino acid substitution matrix for inference of retrovirus and reverse transcriptase phylogeny. J Mol Evol (2002) 2.06
Why are proteins so robust to site mutations? J Mol Biol (2002) 1.87
Integrating influenza antigenic dynamics with molecular evolution. Elife (2014) 1.80
Identifying changes in selective constraints: host shifts in influenza. PLoS Comput Biol (2009) 1.67
Assessing the accuracy of ancestral protein reconstruction methods. PLoS Comput Biol (2006) 1.62
Changing selective pressure during antigenic changes in human influenza H3. PLoS Pathog (2008) 1.61
Myocardial perfusion and function: single photon emission computed tomography. J Nucl Cardiol (2007) 1.58
The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models. Genetics (2011) 1.45
Amino acid coevolution induces an evolutionary Stokes shift. Proc Natl Acad Sci U S A (2012) 1.35
Influence of residue 44 on the activity of the M2 proton channel of influenza A virus. J Gen Virol (2005) 1.28
Myocardial perfusion and function single photon emission computed tomography. J Nucl Cardiol (2006) 1.27
Probing conformational changes in neurotransmitter transporters: a structural context. Eur J Pharmacol (2003) 1.17
Influenza virus infection in travelers to tropical and subtropical countries. Clin Infect Dis (2005) 1.16
H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis. PLoS Pathog (2012) 1.13
Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence. Virus Res (2004) 1.12
Using non-homogeneous models of nucleotide substitution to identify host shift events: application to the origin of the 1918 'Spanish' influenza pandemic virus. J Mol Evol (2009) 1.11
Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol. Antiviral Res (2008) 1.10
Positron emission tomography myocardial perfusion and glucose metabolism imaging. J Nucl Cardiol (2006) 1.09
Optimization of a new score function for the generation of accurate alignments. Proteins (2002) 1.08
Detecting distant homologs using phylogenetic tree-based HMMs. Proteins (2003) 1.05
Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution. Biochemistry (2003) 1.00
Changes in the hemagglutinin of H5N1 viruses during human infection--influence on receptor binding. Virology (2013) 0.98
Performance of an iterated T-HMM for homology detection. Bioinformatics (2004) 0.98
Depicting a protein's two faces: GPCR classification by phylogenetic tree-based HMMs. FEBS Lett (2003) 0.97
Assessing predictors of changes in protein stability upon mutation using self-consistency. PLoS One (2012) 0.96
Analysis of host-parasite incongruence in papillomavirus evolution using importance sampling. Mol Biol Evol (2010) 0.92
Strong evidence for protein epistasis, weak evidence against it. Proc Natl Acad Sci U S A (2014) 0.90
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues. Bioorg Med Chem Lett (2008) 0.87
Predicting functional sites in proteins: site-specific evolutionary models and their application to neurotransmitter transporters. J Mol Biol (2004) 0.86
Conditional ablation of T-cell development by a novel viral ion channel transgene. Immunology (2002) 0.84
Stability and function of the influenza A virus M2 ion channel protein is determined by both extracellular and cytoplasmic domains. Arch Virol (2008) 0.83
Performance evaluation of a new algorithm for the detection of remote homologs with sequence comparison. Proteins (2002) 0.83
Evidence that the CM2 protein of influenza C virus can modify the pH of the exocytic pathway of transfected cells. J Gen Virol (2007) 0.82
Efficient synthesis of highly active phospha-isosteres of the influenza neuraminidase inhibitor oseltamivir. ChemMedChem (2009) 0.82
A model of the mechanisms of language extinction and revitalization strategies to save endangered languages. Hum Biol (2010) 0.80
Evolution of response dynamics underlying bacterial chemotaxis. BMC Evol Biol (2011) 0.80
Functionality and the evolution of marginal stability in proteins: inferences from lattice simulations. Evol Bioinform Online (2007) 0.80
The organization of two rRNA (rrn) operons of the slow-growing pathogen Mycobacterium celatum provides key insights into mycobacterial evolution. FEMS Microbiol Lett (2008) 0.80
Divergence, recombination and retention of functionality during protein evolution. Hum Genomics (2005) 0.79
Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat. Birth Defects Res B Dev Reprod Toxicol (2013) 0.78
Comparison of the activities of BM2 protein and its H19 and W23 mutants of influenza B virus with activities of M2 protein and its H37 and W41 mutants of influenza A virus. Arch Virol (2009) 0.78
Using evolutionary methods to study G-protein coupled receptors. Pac Symp Biocomput (2002) 0.77
A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein. Protein Pept Lett (2002) 0.76
The inhibin B response in male rats treated with two drug candidates. Birth Defects Res B Dev Reprod Toxicol (2013) 0.76
Analytic markovian rates for generalized protein structure evolution. PLoS One (2012) 0.76
The evolution of collective restraint: policing and obedience among non-conjugative plasmids. PLoS Comput Biol (2013) 0.75
In silico biology. Pac Symp Biocomput (2010) 0.75
Second isirv antiviral group conference: overview. Influenza Other Respir Viruses (2013) 0.75
[Impact of avian influenza virus H5N1 neuraminidase mutations on the activity of neuraminidase and the sensibility to neuraminidase inhibitors]. Zhonghua Yi Xue Za Zhi (2010) 0.75