Published in Bioorg Med Chem on October 19, 2010
Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells. PLoS One (2012) 0.90
Targeting SH2 domains in breast cancer. Future Med Chem (2014) 0.82
An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma. PLoS One (2015) 0.80
Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand. PLoS One (2012) 0.80
Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist. Acta Crystallogr F Struct Biol Commun (2014) 0.77
Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer. Int J Clin Exp Pathol (2015) 0.75
Switchable highly regioselective synthesis of 3,4-dihydroquinoxalin-2(1H)ones from o-phenylenediamines and aroylpyruvates. Beilstein J Org Chem (2017) 0.75
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature (2007) 5.31
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. Nature (2006) 3.65
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A (2010) 2.67
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol (2007) 2.55
T cell allorecognition via molecular mimicry. Immunity (2009) 2.25
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature (2008) 2.11
Influenza A virus facilitates Streptococcus pneumoniae transmission and disease. FASEB J (2010) 1.87
Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell (2011) 1.80
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA. J Biol Chem (2002) 1.57
SLIRP, a small SRA binding protein, is a nuclear receptor corepressor. Mol Cell (2006) 1.57
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J Exp Med (2009) 1.45
Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. Mol Cell Biol (2007) 1.44
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor. Immunity (2009) 1.40
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. J Exp Med (2008) 1.40
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature (2010) 1.35
The 1.7 A crystal structure of Dronpa: a photoswitchable green fluorescent protein. J Mol Biol (2006) 1.29
Three-dimensional structure of (1,4)-beta-D-mannan mannanohydrolase from tomato fruit. Protein Sci (2005) 1.24
The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis. J Mol Biol (2006) 1.23
The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane. Biochim Biophys Acta (2003) 1.22
Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells. Lab Invest (2003) 1.21
Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth. Cancer Res (2004) 1.21
Crystal and solution structures of the helicase-binding domain of Escherichia coli primase. J Biol Chem (2005) 1.20
Haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26: X-ray crystallographic studies of dehalogenation of brominated substrates. Biochemistry (2003) 1.19
Crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26 at 0.95 A resolution: dynamics of catalytic residues. Biochemistry (2004) 1.19
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A (2010) 1.13
Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III. Acta Crystallogr D Biol Crystallogr (2003) 1.12
The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism. J Mol Biol (2008) 1.11
Different modes of interaction by TIAR and HuR with target RNA and DNA. Nucleic Acids Res (2011) 1.10
Sequence requirements for RNA binding by HuR and AUF1. J Biochem (2012) 1.09
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. BMC Struct Biol (2007) 1.09
The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity (2007) 1.08
Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition. Breast Cancer Res Treat (2002) 1.04
Selective inhibition of biotin protein ligase from Staphylococcus aureus. J Biol Chem (2012) 1.03
Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition. Biochemistry (2002) 1.01
Experimental determination of quantum dot size distributions, ligand packing densities, and bioconjugation using analytical ultracentrifugation. Nano Lett (2008) 1.01
Crystal structure of LipL32, the most abundant surface protein of pathogenic Leptospira spp. J Mol Biol (2009) 1.00
Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum. Acta Crystallogr D Biol Crystallogr (2004) 0.97
Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme. Biochem J (2005) 0.97
Characterization of a family 11 xylanase from Bacillus subtillis B230 used for paper bleaching. Acta Crystallogr D Biol Crystallogr (2003) 0.94
Grb7-SH2 domain dimerisation is affected by a single point mutation. Eur Biophys J (2005) 0.94
Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases. Structure (2010) 0.93
Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J Biol Chem (2008) 0.93
Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target. Protein Sci (2013) 0.91
RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. PLoS Genet (2013) 0.90
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells. Matrix Biol (2006) 0.89
Structure guided design of biotin protein ligase inhibitors for antibiotic discovery. Curr Top Med Chem (2014) 0.89
Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis. J Mol Biol (2009) 0.89
Distinct binding properties of TIAR RRMs and linker region. RNA Biol (2013) 0.88
Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability. J Biol Chem (2010) 0.88
Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro. Bone (2006) 0.88
Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides. Nucleic Acids Res (2012) 0.88
Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression. J Mol Biol (2011) 0.87
Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly. Nucleic Acids Res (2013) 0.87
Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis. J Mol Biol (2006) 0.87
Jellyfish envenoming syndromes: unknown toxic mechanisms and unproven therapies. Med J Aust (2003) 0.87
HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochem J (2013) 0.86
Crystal structures of the substrate free-enzyme, and reaction intermediate of the HAD superfamily member, haloacid dehalogenase DehIVa from Burkholderia cepacia MBA4. J Mol Biol (2007) 0.86
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions. Biol Chem (2010) 0.86
STI-571 inhibits in vitro angiogenesis. Biochem Biophys Res Commun (2003) 0.86
Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR. Cell Signal (2013) 0.85
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis. J Biol Chem (2008) 0.85
Phanta: a non-fluorescent photochromic acceptor for pcFRET. PLoS One (2013) 0.84
Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity. J Mol Recognit (2012) 0.84
Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status. Biochem J (2013) 0.83
Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase. J Mol Biol (2010) 0.83
Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1. Cell Stress Chaperones (2012) 0.83
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. J Biol Chem (2013) 0.83
Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase. Protein Expr Purif (2004) 0.83
MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: regulation by fibrillar collagen. Exp Cell Res (2002) 0.82
The intracellular and nuclear-targeted delivery of an antiandrogen drug by carrier peptides. Biopolymers (2008) 0.82
Quinine binding by the cocaine-binding aptamer. Thermodynamic and hydrodynamic analysis of high-affinity binding of an off-target ligand. Biochemistry (2013) 0.81
Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. J Biol Chem (2014) 0.81
Purification, crystallization and preliminary crystallographic analysis of biotin protein ligase from Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.81
A role for alphaV integrin subunit in TGF-beta-stimulated osteoclastogenesis. Biochem Biophys Res Commun (2003) 0.80
Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus. Mol Microbiol (2013) 0.80
The 2.1A crystal structure of copGFP, a representative member of the copepod clade within the green fluorescent protein superfamily. J Mol Biol (2006) 0.80
Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism. Biochemistry (2011) 0.80
Synthesis of stapled beta3-peptides through ring-closing metathesis. Org Lett (2009) 0.79
Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils. J Biol Chem (2004) 0.79
Expression, purification, crystallization and preliminary X-ray analysis of eCGP123, an extremely stable monomeric green fluorescent protein with reversible photoswitching properties. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.79
Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells. In Vitro Cell Dev Biol Anim (2007) 0.78
Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy. Biochem Biophys Res Commun (2005) 0.78
Biotin protein ligase from Candida albicans: expression, purification and development of a novel assay. Arch Biochem Biophys (2008) 0.78
Design and testing of bicyclic inhibitors of Grb7-are two cycles better than one? Biopolymers (2013) 0.78
Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain. Biopolymers (2011) 0.78