Published in Cell Cycle on December 15, 2010
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle (2011) 1.92
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 1.85
Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype. Clin Cancer Res (2011) 1.03
TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice. Oncogene (2012) 0.95
The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis (2012) 0.95
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle (2012) 0.83
Novel therapeutic targets of tumor metabolism. Cancer J (2015) 0.82
Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol (2012) 0.80
Targeting the metabolic flexibility of cancer cells: straighten up and die right. Cell Cycle (2011) 0.78
Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30. Cancer Sci (2016) 0.78
Release the ink4a/arf growth suppression by "u" and "me"? Cell Cycle (2011) 0.77
Loss of CC3/TIP30 allows tumor cells to cope with low glucose. Cell Cycle (2011) 0.77
Tat-Interacting Protein 30 (TIP30) Expression Serves as a New Biomarker for Tumor Prognosis: A Systematic Review and Meta-Analysis. PLoS One (2016) 0.75
TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway. Oncogenesis (2017) 0.75
Alteration of cellular metabolism in cancer cells and its therapeutic prospects. J Oral Maxillofac Pathol (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature (2009) 13.28
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol (2006) 7.75
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest (2008) 7.52
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci U S A (2003) 6.87
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene (2009) 5.81
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature (2009) 5.48
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol (2005) 4.99
MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res (2009) 4.32
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab (2010) 4.14
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A (1999) 3.46
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A (2010) 3.08
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle (2010) 3.00
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res (2010) 2.77
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. Biochim Biophys Acta (2009) 2.70
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (2008) 2.09
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol (2010) 2.05
PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J (2009) 1.94
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem (2006) 1.93
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev (2009) 1.93
LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria. Mol Biol Cell (2010) 1.93
AMP-activated protein kinase and cancer. Acta Physiol (Oxf) (2009) 1.64
A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. Oncogene (1997) 1.57
TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes. EMBO J (2000) 1.39
The oncoprotein H-RasV12 increases mitochondrial metabolism. Mol Cancer (2007) 1.33
Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem (2010) 1.27
TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res (2003) 1.20
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J Clin Invest (2008) 1.19
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol (2010) 1.17
TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression. Hum Pathol (2006) 1.16
Decreased TIP30 expression promotes tumor metastasis in lung cancer. Am J Pathol (2009) 1.16
TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma. Cancer Res (2008) 1.15
Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress. Cell Signal (2010) 1.13
Systemic gene delivery expands the repertoire of effective antiangiogenic agents. J Biol Chem (1999) 1.12
TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. J Biol Chem (2004) 1.11
Methylation of Tip30 promoter is associated with poor prognosis in human hepatocellular carcinoma. Clin Cancer Res (2008) 1.09
Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. Mol Cell Biol (2000) 1.05
Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. Oncogene (2001) 1.04
Inhibition of nuclear import by the proapoptotic protein CC3. Mol Cell Biol (2004) 1.02
AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. J Biol Chem (2010) 0.99
Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. J Biol Chem (2005) 0.98
Deletion of Tip30 leads to rapid immortalization of murine mammary epithelial cells and ductal hyperplasia in the mammary gland. Oncogene (2007) 0.95
Reduction of TIP30 correlates with poor prognosis of gastric cancer patients and its restoration drastically inhibits tumor growth and metastasis. Int J Cancer (2009) 0.93
TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases. Curr Biol (1999) 0.91
Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression. Cell Mol Life Sci (2000) 0.90
p32 (C1QBP) and cancer cell metabolism: is the Warburg effect a lot of hot air? Mol Cell Biol (2010) 0.90
CC3/TIP30 affects DNA damage repair. BMC Cell Biol (2010) 0.84
Inhibition of Chk1 by activated PKB/Akt. Cell Cycle (2004) 1.38
Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression. Proc Natl Acad Sci U S A (2010) 1.07
A phase 1B dose escalation trial of Scutellaria barbata (BZL101) for patients with metastatic breast cancer. Breast Cancer Res Treat (2010) 1.03
Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat (2010) 1.02
Inhibition of nuclear import by the proapoptotic protein CC3. Mol Cell Biol (2004) 1.02
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res Treat (2006) 1.02
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One (2009) 1.01
Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PLoS One (2012) 0.89
Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells. Cancer Biol Ther (2008) 0.88
CC3/TIP30 affects DNA damage repair. BMC Cell Biol (2010) 0.84
Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PLoS One (2012) 0.83
Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer (2011) 0.83
Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus. Mech Dev (2002) 0.81
AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation. DNA Repair (Amst) (2004) 0.81
Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus. Gene Expr Patterns (2002) 0.79
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. Int J Cancer (2010) 0.78