Published in PLoS One on December 02, 2010
Neuroadrenergic dysfunction along the diabetes continuum: a comparative study in obese metabolic syndrome subjects. Diabetes (2012) 1.25
Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS One (2011) 0.98
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One (2013) 0.96
Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans. PLoS One (2012) 0.89
Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance. Indian J Endocrinol Metab (2012) 0.87
Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans. Diabetes (2013) 0.87
Risk factors for type 2 diabetes mellitus preceded by β-cell dysfunction, insulin resistance, or both in older adults: the Cardiovascular Health Study. Am J Epidemiol (2013) 0.86
Homeostatic model assessment indices in evaluation of insulin resistance and secretion in hemodialysis patients. Med Sci Monit (2013) 0.83
Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study. PLoS One (2012) 0.80
Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion. Mol Metab (2013) 0.77
Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers. PLoS One (2015) 0.76
DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity. PLoS One (2017) 0.75
Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content. PLoS One (2016) 0.75
Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity. PLoS One (2014) 0.75
Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutr Diabetes (2015) 0.75
The short-term and long-term effects of bariatric/metabolic surgery on subcutaneous adipose tissue inflammation in humans. Metabolism (2017) 0.75
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia (1985) 109.13
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care (1999) 26.39
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care (2008) 4.32
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care (2000) 4.14
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia (2007) 3.34
The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion. Diabet Med (1995) 2.56
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes (2009) 2.51
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One (2007) 2.16
C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes (1984) 2.12
Glucose tolerance and insulin release, a mathematical approach I. Assay of the beta-cell response after oral glucose loading. Diabetes (1976) 2.04
Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia (1984) 1.99
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia (2008) 1.69
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia (2005) 1.64
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes (2009) 1.50
Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One (2008) 1.40
Pathomechanisms of type 2 diabetes genes. Endocr Rev (2009) 1.34
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J Clin Endocrinol Metab (2008) 1.31
A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia (2009) 1.27
Identification and characterization of metabolically benign obesity in humans. Arch Intern Med (2008) 5.74
T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47
An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care (2007) 4.14
Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial. Ann Intern Med (2003) 4.11
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care (2006) 2.99
High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.98
Causes and metabolic consequences of Fatty liver. Endocr Rev (2008) 2.84
Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes (2003) 2.71
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol (2009) 2.43
Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes (2008) 2.41
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab (2008) 2.32
Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes. Diabetes Care (2005) 2.30
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One (2007) 2.16
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem (2004) 2.12
Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity. J Mol Med (Berl) (2001) 2.11
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation (2008) 2.08
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Clin Chem (2009) 2.02
Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One (2008) 2.02
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res (2002) 1.95
Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes (2010) 1.90
Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging (2005) 1.85
Processing of food pictures: influence of hunger, gender and calorie content. Brain Res (2010) 1.77
Identification of proliferative and mature β-cells in the islets of Langerhans. Nature (2016) 1.71
Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes. Radiology (2010) 1.71
Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res (2003) 1.65
High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care (2007) 1.64
Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes (2004) 1.63
Subjective feeling of appetite modulates brain activity: an fMRI study. Neuroimage (2006) 1.59
Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss. Obesity (Silver Spring) (2008) 1.59
Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab (2003) 1.58
Breast-feeding and maternal risk of type 2 diabetes: a prospective study and meta-analysis. Diabetologia (2014) 1.58
Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes (2002) 1.55
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A (2006) 1.51
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes (2009) 1.50
Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Diabetes (2008) 1.48
The obese brain: association of body mass index and insulin sensitivity with resting state network functional connectivity. Hum Brain Mapp (2011) 1.46
Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care (2009) 1.46