Published in Nature on July 21, 2016
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. Nat Commun (2017) 1.39
Human islets contain four distinct subtypes of β cells. Nat Commun (2016) 1.03
Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity. Bioessays (2016) 0.83
Single cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. Genome Res (2016) 0.80
Beta cell heterogeneity: an evolving concept. Diabetologia (2017) 0.79
Pancreatic Beta Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes. Diabetes (2016) 0.78
A platform for high-throughput bioenergy production phenotype characterization in single cells. Sci Rep (2017) 0.77
Physiology: Pancreatic β-cell heterogeneity revisited. Nature (2016) 0.77
β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metab (2017) 0.75
Heterogeneity of the Pancreatic Beta Cell. Front Genet (2017) 0.75
Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants. Sci Rep (2017) 0.75
MiRNAs in β-Cell Development, Identity, and Disease. Front Genet (2017) 0.75
Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes. Front Genet (2017) 0.75
Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Front Genet (2017) 0.75
All mixed up: defining roles for β-cell subtypes in mature islets. Genes Dev (2017) 0.75
Regenerative medicine and cell-based approaches to restore pancreatic function. Nat Rev Gastroenterol Hepatol (2017) 0.75
Interrogating islets in health and disease with single-cell technologies. Mol Metab (2017) 0.75
Age-Dependent decline in the Coordinated [Ca(2+)] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes (2017) 0.75
Is a β cell a β cell? Curr Opin Endocrinol Diabetes Obes (2017) 0.75
Islet amyloid deposits preferentially in the highly functional and most blood perfused islets. Endocr Connect (2017) 0.75
Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols. J Diabetes Res (2017) 0.75
An increase in immature β-cells lacking Glut2 precedes the expansion of β-cell mass in the pregnant mouse. PLoS One (2017) 0.75
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat Commun (2017) 0.75
Reconstructing human pancreatic differentiation by mapping specific cell populations during development. Elife (2017) 0.75
Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas. Mol Metab (2017) 0.75
Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants. Curr Diab Rep (2017) 0.75
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Identification and characterization of metabolically benign obesity in humans. Arch Intern Med (2008) 5.74
A genome-wide perspective of genetic variation in human metabolism. Nat Genet (2009) 5.00
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47
An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care (2007) 4.14
Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial. Ann Intern Med (2003) 4.11
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev (2004) 3.79
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab (2004) 3.54
Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care (2006) 2.99
Causes and metabolic consequences of Fatty liver. Endocr Rev (2008) 2.84
Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes (2003) 2.71
Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet (2011) 2.68
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell (2005) 2.57
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol (2010) 2.52
Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes (2008) 2.41
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes (2009) 2.36
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol (2003) 2.34
Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab (2008) 2.32
Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol (2004) 2.31
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci (2011) 2.25
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One (2007) 2.16
Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis (2010) 2.14
Widespread amyloid deposition in transplanted human pancreatic islets. N Engl J Med (2008) 2.13
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem (2004) 2.12
Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity. J Mol Med (Berl) (2001) 2.11
Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther (2002) 2.10
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation (2008) 2.08
Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study. Diabetologia (2014) 2.04
Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell (2002) 2.03
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Clin Chem (2009) 2.02
Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One (2008) 2.02
Glutamate is a positive autocrine signal for glucagon release. Cell Metab (2008) 2.01
Utilization of small pediatric donors including infants for pancreas and kidney transplantation: exemplification of the surgical technique and the surveillance. Ann Surg (2014) 2.01
Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes (2005) 1.96
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell (2013) 1.96
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell (2010) 1.95
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res (2002) 1.95
Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods (2005) 1.93
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab (2012) 1.93
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion. J Clin Invest (2012) 1.91
Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes (2010) 1.90
Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology (2010) 1.80
FGF23 is processed by proprotein convertases but not by PHEX. Bone (2004) 1.79
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology (2013) 1.77
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes. Radiology (2010) 1.71
Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology (2004) 1.70
Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res (2003) 1.65
High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care (2007) 1.64
Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture. Transplantation (2004) 1.64
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Science (2009) 1.63
Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes (2004) 1.63
Current advances and travails in islet transplantation. Diabetes (2009) 1.63
Differences between human plasma and serum metabolite profiles. PLoS One (2011) 1.61
High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab (2002) 1.59
Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss. Obesity (Silver Spring) (2008) 1.59
Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab (2003) 1.58
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell (2013) 1.57
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature (2010) 1.56
Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes (2002) 1.55
Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pig. Crit Care Med (2011) 1.52
In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae. Immunity (2005) 1.52
Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Invest (2016) 1.52
Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins. J Pathol (2013) 1.51
Targeted estrogen delivery reverses the metabolic syndrome. Nat Med (2012) 1.51
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A (2006) 1.51
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes (2009) 1.50
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Development (2009) 1.48
Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Diabetes (2008) 1.48
Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes (2003) 1.48
The obese brain: association of body mass index and insulin sensitivity with resting state network functional connectivity. Hum Brain Mapp (2011) 1.46
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol (2009) 1.46
Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care (2009) 1.46