Published in Anticancer Res on December 01, 2010
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res (2011) 1.20
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Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp. Mar Drugs (2013) 0.75
NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron (2004) 3.24
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A (2005) 2.92
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst (2003) 2.31
Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res (2007) 2.26
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J Med Chem (2005) 2.12
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst (2005) 2.09
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Cancer prevention with natural compounds. Semin Oncol (2010) 1.98
Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci (2002) 1.88
Bisphenol A promotes human prostate stem-progenitor cell self-renewal and increases in vivo carcinogenesis in human prostate epithelium. Endocrinology (2014) 1.81
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. J Med Chem (2007) 1.76
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol (2009) 1.75
What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One (2011) 1.74
New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. J Nat Prod (2002) 1.74
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J Org Chem (2004) 1.69
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives. Mol Cancer Ther (2009) 1.64
Human, rat, and mouse metabolism of resveratrol. Pharm Res (2002) 1.62
Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem (2003) 1.56
Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes. J Nat Prod (2009) 1.48
NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother Res (2010) 1.45
Natural inhibitors of carcinogenesis. Planta Med (2004) 1.43
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem (2010) 1.41
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests. J Nat Prod (2002) 1.39
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol (2006) 1.36
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem (2002) 1.36
A genomic variation map provides insights into the genetic basis of cucumber domestication and diversity. Nat Genet (2013) 1.34
Synthesis and anticancer activity of brefeldin A ester derivatives. J Med Chem (2006) 1.32
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Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol (2004) 1.29
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles. J Med Chem (2006) 1.29
Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins. J Med Chem (2008) 1.28
Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J (2010) 1.26
Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci (2007) 1.24
Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod (2006) 1.24
Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen. J Med Chem (2003) 1.22
Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model. J Med Chem (2002) 1.21
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin Cancer Res (2003) 1.21
Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings. J Med Chem (2004) 1.20
Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res (2011) 1.20
A luminescent homochiral 3D Cd(II) framework with a threefold interpenetrating uniform net 8(6). Chem Commun (Camb) (2009) 1.20
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem (2002) 1.19
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids. J Med Chem (2003) 1.19
Prognostic value of diametrically polarized tumor-associated macrophages in renal cell carcinoma. Ann Surg Oncol (2014) 1.18
Total synthesis and biological evaluation of 22-hydroxyacuminatine. J Med Chem (2006) 1.18
On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex. J Med Chem (2005) 1.17
Suppression of TNF-α induced NFκB activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. Nat Prod Res (2010) 1.17
Regulation of miR-19 to breast cancer chemoresistance through targeting PTEN. Pharm Res (2011) 1.16
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors. Bioorg Med Chem (2004) 1.15
"Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact. J Nat Prod (2006) 1.14
Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells. J Biol Chem (2013) 1.13
Investigation of a method for generating synthetic CT models from MRI scans of the head and neck for radiation therapy. Phys Med Biol (2013) 1.13
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. Biochemistry (2005) 1.12
Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila) (2010) 1.11
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors. Bioorg Med Chem Lett (2006) 1.11
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors. Bioorg Med Chem Lett (2004) 1.10
Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. J Med Chem (2007) 1.10
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr (2002) 1.09
Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J Nat Prod (2007) 1.09
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem (2009) 1.09
A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population. Hum Mol Genet (2011) 1.09
Use of the in vivo hollow fiber assay in natural products anticancer drug discovery. J Nat Prod (2009) 1.09
Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry (2010) 1.08
Induction of quinone reductase as a primary screen for natural product anticarcinogens. Methods Enzymol (2004) 1.07
A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor. J Med Chem (2006) 1.07
Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. J Med Chem (2007) 1.07
Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. J Med Chem (2007) 1.07
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod (2004) 1.06
Cytotoxic withanolides from Acnistus arborescens. Phytochemistry (2002) 1.05
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. J Med Chem (2008) 1.05
PES1 promotes breast cancer by differentially regulating ERα and ERβ. J Clin Invest (2012) 1.05
MAIT recognition of a stimulatory bacterial antigen bound to MR1. J Immunol (2013) 1.04
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. Diabetes (2013) 1.04
An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes. J Am Chem Soc (2005) 1.04
Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett (2005) 1.02
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J Mol Biol (2003) 1.02
The binding orientation of a norindenoisoquinoline in the topoisomerase I-DNA cleavage complex is primarily governed by pi-pi stacking interactions. J Phys Chem B (2008) 1.02
Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs (2012) 1.01
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine. Structure (2002) 1.01
A comparative evaluation of the anticancer properties of European and American elderberry fruits. J Med Food (2006) 1.00
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod (2003) 1.00
Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam. Nat Prod Commun (2009) 1.00
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors. J Med Chem (2004) 1.00
Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Med (2006) 1.00
Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines. Bioorg Med Chem Lett (2005) 0.99
A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. Schizophr Res (2007) 0.99
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. J Med Chem (2007) 0.99
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. Bioorg Med Chem (2006) 0.99
Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. J Med Chem (2010) 0.99
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J Mol Biol (2002) 0.99
Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Phytochemistry (2002) 0.98
Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod (2004) 0.98
New 3-d chiral framework of indium with 1,3,5-benzenetricarboxylate. Inorg Chem (2005) 0.98