Published in Mol Biol Cell on January 05, 2011
Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep (2011) 1.30
Regulation of protein kinase D1 activity. Mol Pharmacol (2011) 1.13
Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem (2011) 1.10
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. J Cell Sci (2012) 0.98
Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics (2012) 0.95
Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4. Biochem J (2013) 0.89
Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem (2013) 0.89
Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells. Biochem J (2012) 0.88
Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. Nat Protoc (2014) 0.88
Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer. Mol Cancer Ther (2012) 0.87
Protein kinase D1-mediated phosphorylations regulate vasodilator-stimulated phosphoprotein (VASP) localization and cell migration. J Biol Chem (2013) 0.87
GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. J Biol Chem (2012) 0.84
Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. J Virol (2013) 0.83
Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks. Mol Cell Proteomics (2014) 0.82
Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion. J Clin Med (2016) 0.81
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer. Cell Mol Life Sci (2015) 0.80
Protein kinase D interacts with neuronal nitric oxide synthase and phosphorylates the activatory residue serine 1412. PLoS One (2014) 0.80
Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover. Mol Biol Cell (2016) 0.75
Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion. J Biol Chem (2015) 0.75
Potein Kinase D Signaling in Cancer: A Friend or Foe? Biochim Biophys Acta (2017) 0.75
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol (2006) 12.13
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics (2005) 4.33
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol (2005) 3.20
Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell (2005) 3.10
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. Cancer Res (2006) 2.69
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
PKD at the crossroads of DAG and PKC signaling. Trends Pharmacol Sci (2006) 2.46
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev Cell (2001) 2.46
Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A (1997) 2.43
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol (2004) 2.36
alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol (2007) 2.31
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol (2009) 2.31
Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci U S A (1996) 2.19
Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci (2003) 2.10
A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03
Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol (2007) 1.90
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol (2002) 1.72
Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. J Biol Chem (2001) 1.65
E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer. Cancer Res (2005) 1.62
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol (2005) 1.55
Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Res (2009) 1.55
Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J Biol Chem (2003) 1.47
A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. Mol Cell Biol (1995) 1.43
Derepression of pathological cardiac genes by members of the CaM kinase superfamily. Cardiovasc Res (2006) 1.41
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell (2007) 1.39
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. J Biol Chem (2010) 1.32
c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem (2006) 1.29
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Mol Cell Biol (2002) 1.29
PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett (2007) 1.26
Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis (2008) 1.24
Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. J Cell Sci (2006) 1.21
The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis. J Biol Chem (2003) 1.20
Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration. Mol Cell Biol (2007) 1.20
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci (2008) 1.17
The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci U S A (2008) 1.15
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol (2008) 1.13
The RAS effector RIN1 modulates the formation of aversive memories. J Neurosci (2003) 1.08
Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity (1997) 1.07
Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis. Proteomics (2006) 1.05
RIN1 is a breast tumor suppressor gene. Cancer Res (2007) 1.05
Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. J Biol Chem (2007) 1.03
In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase C mu. FEBS Lett (1996) 1.00
Role of rab5 in EGF receptor-mediated signal transduction. Eur J Cell Biol (2004) 0.99
Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms. J Biol Chem (2008) 0.96
Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol Biol Cell (2009) 0.92
The RIN family of Ras effectors. Methods Enzymol (2006) 0.84
RAS interaction with effector target RIN1. Methods Enzymol (2001) 0.80
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol (2005) 3.20
Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06
Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol (2007) 1.90
Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci (2002) 1.88
Pain palliation in patients with bone metastases using MR-guided focused ultrasound surgery: a multicenter study. Ann Surg Oncol (2008) 1.85
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J Biol Chem (2008) 1.78
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Res (2009) 1.55
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways. J Biol Chem (2001) 1.46
Standardized antipyretic treatment in stroke: a pilot study. Cerebrovasc Dis (2011) 1.42
CT-guided interstitial brachytherapy of liver malignancies alone or in combination with thermal ablation: phase I-II results of a novel technique. Int J Radiat Oncol Biol Phys (2004) 1.38
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J (2011) 1.36
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. J Biol Chem (2010) 1.32
Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. J Biol Chem (2003) 1.32
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem (2004) 1.26
PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett (2007) 1.26
Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. J Cell Sci (2006) 1.21
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci (2008) 1.17
Novel hemoglobin variant [beta66(E10) Lys-->Asn], with decreased oxygen affinity, causes falsely low hemoglobin A1c values by HPLC. Clin Chem (2003) 1.17
Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon). J Biol Chem (2002) 1.16
Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain. J Biomech (2002) 1.15
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14
Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arterioscler Thromb Vasc Biol (2007) 1.13
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L. J Biol Chem (2005) 1.12
Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases. Mol Biol Cell (2013) 1.07
Liver malignancies: CT-guided interstitial brachytherapy in patients with unfavorable lesions for thermal ablation. J Vasc Interv Radiol (2004) 1.06
Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci (2009) 1.05
Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis. Proteomics (2006) 1.05
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci (2012) 1.04
A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents. Mol Cell Biol (2005) 1.02
Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. J Immunol (2004) 1.01
Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J (2007) 1.00
Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO J (2008) 1.00
Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1. FASEB J (2006) 0.99
Multi-level control of actin dynamics by protein kinase D. Cell Signal (2013) 0.96
The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal. J Biol Chem (2005) 0.95
Development and immunochemical evaluation of antibodies Y for the poorly immunogenic polypeptide prothymosin alpha. Peptides (2005) 0.95
Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics (2012) 0.95
Biochemical characterization of individual injury pattern and injury severity. Injury (2003) 0.94
The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J Biol Chem (2008) 0.93
Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Gene Expr Patterns (2006) 0.92
Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol Biol Cell (2009) 0.92
Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells. J Immunol (2005) 0.91
Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model. Arch Orthop Trauma Surg (2006) 0.90
Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein. J Biol Chem (2012) 0.90
Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem (2013) 0.89
Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J Biol Chem (2012) 0.88
Protein kinase D regulates several aspects of development in Drosophila melanogaster. BMC Dev Biol (2007) 0.88
Expression patterns of protein kinase D 3 during mouse development. BMC Dev Biol (2008) 0.88
Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1. EMBO Rep (2011) 0.87
[CT-Guided brachytherapy. A novel percutaneous technique for interstitial ablation of liver metastases]. Strahlenther Onkol (2004) 0.87
Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels. J Gen Virol (2008) 0.87
Physiological functions of protein kinase D in vivo. IUBMB Life (2013) 0.86
Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1. J Biol Chem (2005) 0.85
A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal. Traffic (2009) 0.85
The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunol Immunother (2006) 0.84
Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells. J Biotechnol (2009) 0.84
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain. Biol Chem (2006) 0.84
Three C-terminal phosphorylation sites in the Abutilon mosaic virus movement protein affect symptom development and viral DNA accumulation. Virology (2009) 0.84
GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. J Biol Chem (2012) 0.84
Impact of Ga-68 DOTATOC PET/CT on the diagnosis and treatment of patients with multiple endocrine neoplasia. Ann Nucl Med (2012) 0.83
Protein kinase D controls voluntary-running-induced skeletal muscle remodelling. Biochem J (2011) 0.82
Cartilage surface characterization by frictional dissipated energy during axially loaded knee flexion--an in vitro sheep model. J Biomech (2013) 0.82
The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. PLoS One (2011) 0.81
The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Exp Cell Res (2010) 0.81
SLy2 targets the nuclear SAP30/HDAC1 complex. Int J Biochem Cell Biol (2010) 0.81
Characterization of the carbohydrate moieties of the functional unit RvH1-a of Rapana venosa haemocyanin using HPLC/electrospray ionization MS and glycosidase digestion. Biochem J (2003) 0.81
Sonographically guided venous puncture and fluoroscopically guided placement of tunneled, large-bore central venous catheters for bone marrow transplantation-high success rates and low complication rates. Support Care Cancer (2008) 0.81
Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS One (2011) 0.81
PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. Mol Biol Cell (2012) 0.81
A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo. Stem Cells Dev (2014) 0.80
Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network. Biochim Biophys Acta (2011) 0.80
Intact fibula improves fracture healing in a rat tibia osteotomy model. J Orthop Res (2005) 0.80
Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro. Immunology (2007) 0.80
Coordination of three and four Cu(I) to the alpha- and beta-domain of vertebrate Zn-metallothionein-1, respectively, induces significant structural changes. FEBS J (2007) 0.79
Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1. J Invest Dermatol (2011) 0.79
Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358). Biochem Biophys Res Commun (2008) 0.79
Changes in dipolar structure of cardiac magnetic field maps after ST elevation myocardial infarction. Ann Noninvasive Electrocardiol (2011) 0.79
T cell epitope definition by differential mass spectrometry: identification of a novel, immunogenic HLA-B8 ligand directly from renal cancer tissue. Proteomics (2006) 0.79
Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells. Metab Eng (2013) 0.78
G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-network. Biotechnol J (2011) 0.78
Spermine isolated and identified as the major trypanocidal compound from the snake venom of Eristocophis macmahoni causes autophagy in Trypanosoma brucei. Toxicon (2007) 0.78
The differential influence of non-iodinated and mono- or diiodinated benzoic acids on cellular and nuclear uptake of the nuclear localization sequence of the SV 40 T antigen. Int J Pharm (2007) 0.78
A new tool for the quantitative analysis of dendritic filopodial motility. Cytometry A (2014) 0.78
Local head and neck cooling leads to hypothermia in healthy volunteers. Cerebrovasc Dis (2011) 0.77
Structure-activity relationship of an alpha-toxin Bs-Tx28 from scorpion (Buthus sindicus) venom suggests a new alpha-toxin subfamily. Arch Biochem Biophys (2005) 0.77
Antitumor activity of glycosylated molluscan hemocyanins via Guerin ascites tumor. Immunol Invest (2010) 0.75
Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site. Cytoskeleton (Hoboken) (2015) 0.75
Investigation of a capillary electrophoretic approach for direct quantification of apolipoprotein A-I in serum. Electrophoresis (2003) 0.75
Organic food processing: a framework for concept, starting definitions and evaluation. J Sci Food Agric (2014) 0.75
Influence of preoperative mechanical bone quality and bone mineral density on aseptic loosening of total hip arthroplasty after seven years. Clin Biomech (Bristol, Avon) (2003) 0.75