Published in Mol Biol Cell on December 11, 2013
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HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. Cancer Res (2014) 0.90
Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101. Mol Cancer Ther (2015) 0.87
Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion. J Clin Med (2016) 0.81
Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis. Front Cell Dev Biol (2016) 0.80
Protein Kinase D family kinases: roads start to segregate. Bioarchitecture (2014) 0.78
Protein kinase D enzymes: novel kinase targets in pancreatic cancer. Expert Rev Gastroenterol Hepatol (2015) 0.76
A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Sci Rep (2015) 0.76
Pancreatic oncogenic signaling cascades converge at Protein Kinase D1. Cell Cycle (2015) 0.76
Helicobacter pylori-induced changes in microtubule dynamics conferred by α-tubulin phosphorylation on Ser/Tyr mediate gastric mucosal secretion of matrix metalloproteinase-9 (MMP-9) and its modulation by ghrelin. Inflammopharmacology (2016) 0.75
Role of protein kinase D2 phosphorylation on Tyr in modulation by ghrelin of Helicobacter pylori-induced up-regulation in gastric mucosal matrix metalloproteinase-9 (MMP-9) secretion. Inflammopharmacology (2016) 0.75
A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer. Mol Cell Oncol (2015) 0.75
Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion. J Biol Chem (2015) 0.75
Potein Kinase D Signaling in Cancer: A Friend or Foe? Biochim Biophys Acta (2017) 0.75
Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion. Sci Rep (2017) 0.75
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Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol (2005) 3.20
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59
Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques (2005) 2.55
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol (2009) 2.31
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest (2002) 2.28
Protein kinase D: a family affair. FEBS Lett (2003) 2.09
Pathways for aberrant angiogenesis in pancreatic cancer. Mol Cancer (2003) 1.61
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2010) 1.58
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Res (2009) 1.55
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res (2009) 1.55
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Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation. Lab Invest (2001) 1.33
Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Gut (2010) 1.32
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. J Biol Chem (2010) 1.32
Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase. Int J Cancer (2005) 1.29
PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett (2007) 1.26
Stromelysin-3 expression promotes tumor take in nude mice. J Clin Invest (1996) 1.19
Role of protein kinase D signaling in pancreatic cancer. Biochem Pharmacol (2010) 1.14
Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer. Cancer Res (2010) 1.02
Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport. Mol Biol Cell (2010) 0.99
Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1. J Biol Chem (2012) 0.96
Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts. Biochem Biophys Res Commun (2011) 0.92
Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein. J Biol Chem (2012) 0.90
Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Am J Physiol Gastrointest Liver Physiol (2002) 0.90
Peritoneal metastases in pancreatic carcinoma. Hepatogastroenterology (1993) 0.90
Snail promotes an invasive phenotype in lung carcinoma. Respir Res (2012) 0.89
Novel protein kinases in pancreatic cell growth and cancer. Int J Gastrointest Cancer (2002) 0.88
Matrix metalloproteinase (MMP)-7 activates MMP-8 but not MMP-13. Med Chem (2006) 0.88
Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer. Mol Cancer Ther (2012) 0.87
Novel approaches to target pancreatic cancer. Curr Cancer Drug Targets (2011) 0.85
A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. Oncogene (2013) 0.85
Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. J Clin Oncol (2007) 4.14
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol (2005) 3.20
The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study. Arch Iran Med (2009) 2.67
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59
Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci (2002) 2.17
Protein kinase D: a family affair. FEBS Lett (2003) 2.09
Significantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system. BMC Cell Biol (2010) 2.04
ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody. MAbs (2010) 2.03
Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol (2007) 1.90
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Nat Cell Biol (2003) 1.84
Protein kinase D: an intracellular traffic regulator on the move. Trends Cell Biol (2002) 1.81
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J Biol Chem (2008) 1.78
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J Exp Med (2005) 1.72
IgG4-related autoimmune diseases: Polymorphous presentation complicates diagnosis and treatment. Dtsch Arztebl Int (2015) 1.70
Non-apoptotic Fas signaling. Cytokine Growth Factor Rev (2003) 1.57
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Res (2009) 1.55
Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways. J Biol Chem (2001) 1.46
Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43
Rapid research education for medical science students. Lancet (2013) 1.39
Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Gut (2010) 1.32
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. J Biol Chem (2010) 1.32
Prognostic indicators of survival in patients with compensated and decompensated cirrhosis. Liver Int (2012) 1.29
Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells. Cancer Res (2004) 1.28
Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharmacol (2008) 1.26
Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts. J Biol Chem (2004) 1.26
PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration. FEBS Lett (2007) 1.26
Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. J Cell Sci (2007) 1.22
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation (2010) 1.22
Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. J Cell Sci (2006) 1.21
Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther (2013) 1.20
Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon). J Biol Chem (2002) 1.16
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14
Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arterioscler Thromb Vasc Biol (2007) 1.13
Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis. Mol Med (2002) 1.12
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol (2006) 1.11
Tumor therapeutics by design: targeting and activation of death receptors. Cytokine Growth Factor Rev (2005) 1.10
Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling. Mol Biol Cell (2005) 1.10
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability. J Cell Biol (2005) 1.10
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells. J Immunol (2012) 1.07
Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity. J Immunol (2008) 1.07
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci (2012) 1.04
Evaluation of health related quality of life in irritable bowel syndrome patients. Health Qual Life Outcomes (2012) 1.03
A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration. Mol Biol Cell (2011) 1.02
Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia (2013) 1.02
The future role of the gastroenterologist in digestive oncology: an international perspective. Gastroenterology (2011) 1.01
Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells. Gastroenterology (2003) 1.01
A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. PLoS One (2011) 1.01
Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J (2007) 1.00
Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport. Mol Biol Cell (2010) 0.99
Serum oxidized-LDL is associated with diabetes duration independent of maintaining optimized levels of LDL-cholesterol. Lipids (2010) 0.99
TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports (2013) 0.98
Superior serum half life of albumin tagged TNF ligands. Biochem Biophys Res Commun (2010) 0.97
Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor. J Biol Chem (2002) 0.97
Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1. J Biol Chem (2012) 0.96
Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics (2012) 0.95
Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-beta pathways in human breast cancer cells. Mol Endocrinol (2004) 0.94
Oxaliplatin in combination with 5-fluorouracil/leucovorin or capecitabine in elderly patients with metastatic colorectal cancer. Clin Colorectal Cancer (2008) 0.94
Targeted treatments in colorectal cancer: state of the art and future perspectives. Gut (2010) 0.94
A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. J Immunother (2008) 0.92
Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol Biol Cell (2009) 0.92
Characterization of cortactin as an in vivo protein kinase D substrate: interdependence of sites and potentiation by Src. Cell Signal (2008) 0.92
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. Cell Signal (2008) 0.92
Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Gene Expr Patterns (2006) 0.92
Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB. Cell Signal (2007) 0.92
Generation of a FasL-based proapoptotic fusion protein devoid of systemic toxicity due to cell-surface antigen-restricted Activation. J Biol Chem (2003) 0.91
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation. Neuro Oncol (2011) 0.91
The phosphatase of regenerating liver 3 (PRL-3) promotes cell migration through Arf-activity-dependent stimulation of integrin α5 recycling. J Cell Sci (2012) 0.91
A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer. Cancer Res (2006) 0.91
Tumor necrosis factor (TNF)-functionalized nanostructured particles for the stimulation of membrane TNF-specific cell responses. Bioconjug Chem (2005) 0.91
Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functionalized particles to tumor cells. J Control Release (2009) 0.91
Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Am J Physiol Gastrointest Liver Physiol (2002) 0.90
Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 protein. J Biol Chem (2012) 0.90
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells. Oncogene (2005) 0.90
Serum adenosine deaminase may predict disease activity in rheumatoid arthritis. Rheumatol Int (2011) 0.89
Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines. Eur J Cell Biol (2007) 0.89
Engineering death receptor ligands for cancer therapy. Cancer Lett (2011) 0.89
Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS J (2008) 0.89
TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor. Oncogene (2002) 0.89
Expression patterns of protein kinase D 3 during mouse development. BMC Dev Biol (2008) 0.88
Attitude towards plagiarism among Iranian medical students. J Med Ethics (2012) 0.88
Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J Biol Chem (2012) 0.88
Propranolol impairs liver regeneration after partial hepatectomy in C57Bl/6-mice by transient attenuation of hepatic lipid accumulation and increased apoptosis. Scand J Gastroenterol (2010) 0.88
Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export. EMBO J (2013) 0.87
Palliative treatment of pancreatic cancer. J Dig Dis (2008) 0.87
The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. Cell Signal (2006) 0.87
TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. Biochem Biophys Res Commun (2013) 0.87
Therapeutic targeting of CD95 and the TRAIL death receptors. Recent Pat Anticancer Drug Discov (2011) 0.86