PubRank

Andrew J Brown

Author PubWeight™ 91.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The DNA sequence of the human X chromosome. Nature 2005 6.97
2 Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 2008 2.85
3 Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem 2003 2.52
4 ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol 2005 2.46
5 Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux. Arterioscler Thromb Vasc Biol 2004 1.92
6 A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet 2011 1.69
7 The Akt-SREBP nexus: cell signaling meets lipid metabolism. Trends Endocrinol Metab 2010 1.55
8 The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 2008 1.54
9 Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus. AIDS 2003 1.52
10 Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis. Mol Biol Cell 2006 1.49
11 A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. J Cell Biol 2011 1.48
12 Reducing safety-related drug attrition: the use of in vitro pharmacological profiling. Nat Rev Drug Discov 2012 1.47
13 Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised. Prog Lipid Res 2008 1.46
14 Effect of venipuncture quality on thromboelastography. J Vet Emerg Crit Care (San Antonio) 2012 1.38
15 OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem 2007 1.23
16 SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. Biochem J 2006 1.22
17 Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids. J Biol Chem 2008 1.21
18 GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res 2011 1.21
19 Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). J Biol Chem 2013 1.19
20 Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase. Cell Metab 2011 1.18
21 Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. Am J Pathol 2002 1.18
22 Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55. Mol Endocrinol 2011 1.17
23 Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis. J Lipid Res 2011 1.14
24 Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation. Am J Pathol 2011 1.10
25 Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. J Biol Chem 2007 1.08
26 Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen 2013 1.08
27 G protein-coupled receptors for free fatty acids. Cell Signal 2006 1.05
28 The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55. J Biol Chem 2012 1.05
29 Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum. J Biol Chem 2004 1.04
30 Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 2007 1.03
31 A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. Biochem J 2012 1.01
32 The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation. Atherosclerosis 2007 1.00
33 Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol 2007 1.00
34 An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Rep 2012 0.99
35 The origin of multiple B mating specificities in Coprinus cinereus. Genetics 2005 0.98
36 Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis. Prog Lipid Res 2013 0.98
37 Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life? Free Radic Biol Med 2009 0.98
38 Rapamycin down-regulates LDL-receptor expression independently of SREBP-2. Biochem Biophys Res Commun 2008 0.96
39 Akt phosphorylates Sec24: new clues into the regulation of ER-to-Golgi trafficking. Traffic 2010 0.96
40 Novel routes for metabolism of 7-ketocholesterol. Rejuvenation Res 2005 0.94
41 Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target. Int J Cancer 2010 0.94
42 A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther 2013 0.93
43 Oxysterols in biological systems: sources, metabolism and pathophysiological relevance. Redox Rep 2006 0.93
44 The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway. Mol Cell Biol 2014 0.91
45 Yeast assays for G protein-coupled receptors. Methods Mol Biol 2009 0.90
46 Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins. Biochim Biophys Acta 2012 0.90
47 The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). Biochim Biophys Acta 2011 0.89
48 Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1. J Biol Chem 2014 0.89
49 Expression and stability of two isoforms of ABCG1 in human vascular cells. Atherosclerosis 2009 0.89
50 Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. J Neurochem 2007 0.88
51 Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. Lipids Health Dis 2007 0.88
52 The role of signalling in cellular cholesterol homeostasis. IUBMB Life 2013 0.87
53 Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands. Biochem J 2005 0.86
54 Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells. Biochem Biophys Res Commun 2008 0.86
55 Akt acutely activates the cholesterogenic transcription factor SREBP-2. Biochim Biophys Acta 2011 0.86
56 Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis. J Lipid Res 2013 0.86
57 What dictates the accumulation of desmosterol in the developing brain? FASEB J 2012 0.85
58 Pyridine-3-carboxamides as novel CB(2) agonists for analgesia. Bioorg Med Chem Lett 2008 0.84
59 Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: implications for cholesterol trafficking to the endoplasmic reticulum. Biochim Biophys Acta 2008 0.83
60 The association of blood lactate concentration with outcome in dogs with idiopathic immune-mediated hemolytic anemia: 173 cases (2003-2006). J Vet Emerg Crit Care (San Antonio) 2010 0.82
61 Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt. Biochem J 2012 0.82
62 Is seladin-1 really a selective Alzheimer's disease indicator? J Alzheimers Dis 2012 0.82
63 Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain. J Med Chem 2009 0.82
64 Effects of delayed anticoagulation and use of evacuated tubes on non-activated thrombelastography in dogs. Vet Clin Pathol 2012 0.81
65 Protein kinase A modulates the activity of a major human isoform of ABCG1. J Lipid Res 2012 0.81
66 Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses. J Biol Chem 2012 0.81
67 Accumulation of squalene is associated with the clustering of lipid droplets. FEBS J 2012 0.81
68 Alcohol and water adsorption in zeolitic imidazolate frameworks. Chem Commun (Camb) 2013 0.81
69 The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III. Traffic 2012 0.79
70 DHCR24 associates strongly with the Endoplasmic Reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme. Biosci Rep 2014 0.78
71 Species variation in ABCG1 isoform expression: implications for the use of animal models in elucidating ABCG1 function. Atherosclerosis 2012 0.78
72 Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. J Virol 2011 0.78
73 A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo. Pain 2013 0.78
74 Atherosclerosis: cell biology and lipoproteins: cholesterol absorption inhibitors: gateway therapy for hypercholesterolaemia. Curr Opin Lipidol 2002 0.78
75 Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. Biochim Biophys Acta 2002 0.77
76 Predicting response to statins by pharmacogenetic testing. Pharmacogenomics 2012 0.77
77 How essential is cholesterol? Biochem J 2009 0.77
78 Does upsizing statins have a downside? Drug Saf 2010 0.75
79 Effects of simulated injury on the anteroinferior glenohumeral capsule. Med Biol Eng Comput 2012 0.75
80 Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci 2014 0.75
81 2-Amino-5-aryl-pyridines as selective CB2 agonists: synthesis and investigation of structure-activity relationships. Bioorg Med Chem Lett 2009 0.75
82 Linear trinuclear cobalt(II) single molecule magnet. Dalton Trans 2015 0.75
83 Continuous versus intermittent delivery of nutrition via nasoenteric feeding tubes in hospitalized canine and feline patients: 91 patients (2002-2007). J Vet Emerg Crit Care (San Antonio) 2010 0.75
84 Trends in plasma transfusion at a veterinary teaching hospital: 308 patients (1996-1998 and 2006-2008). J Vet Emerg Crit Care (San Antonio) 2010 0.75
85 Approaches to investigate the role of signaling in ER-to-Golgi transport. Methods Mol Biol 2008 0.75
86 Defects in coagulation encountered in small animal critical care. Vet Clin North Am Small Anim Pract 2011 0.75
87 Clinical experience utilizing a novel fluoroscopic technique for wire-guided nasojejunal tube placement in the dog: 26 cases (2006-2010). J Vet Emerg Crit Care (San Antonio) 2011 0.75
88 Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR. J Nutr Sci Vitaminol (Tokyo) 2015 0.75
89 Exploiting a physiological regulator to improve the efficacy and safety of statins. Cardiovasc Drugs Ther 2011 0.75
90 Silylated mesoporous silica membranes on polymeric hollow fiber supports: synthesis and permeation properties. ACS Appl Mater Interfaces 2014 0.75
91 Investigating signaling processes in membrane trafficking. Methods Mol Biol 2015 0.75
92 Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain. Bioorg Med Chem Lett 2009 0.75
93 Liposomes loaded with a dirhenium compound and cisplatin: preparation, properties and improved in vivo anticancer activity. J Liposome Res 2014 0.75
94 Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression. Atherosclerosis 2013 0.75